Gene description for STAB2
Gene name stabilin 2
Gene symbol STAB2
Other names/aliases FEEL2
Species Homo sapiens
 Database cross references - STAB2
ExoCarta ExoCarta_55576
Entrez Gene 55576
HGNC 18629
MIM 608561
UniProt Q8WWQ8  
 STAB2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for STAB2
Molecular Function
    low-density lipoprotein receptor activity GO:0005041 IDA
    protein binding GO:0005515 IPI
    scavenger receptor activity GO:0005044 IDA
    low-density lipoprotein particle binding GO:0030169 IDA
    protein disulfide oxidoreductase activity GO:0015035 NAS
    hyaluronic acid binding GO:0005540 ISS
Biological Process
    regulation of gene expression GO:0010468 IMP
    carbohydrate metabolic process GO:0005975 TAS
    hyaluronan metabolic process GO:0030212 TAS
    oxidation-reduction process GO:0055114 NAS
    receptor-mediated endocytosis GO:0006898 TAS
    small molecule metabolic process GO:0044281 TAS
    cell adhesion GO:0007155 NAS
    endocytosis GO:0006897 ISS
    glycosaminoglycan metabolic process GO:0030203 TAS
    hyaluronan catabolic process GO:0030214 TAS
    angiogenesis GO:0001525 NAS
    regulation of blood coagulation GO:0030193 IMP
    defense response to bacterium GO:0042742 IDA
Subcellular Localization
    external side of plasma membrane GO:0009897 ISS
    integral component of plasma membrane GO:0005887 IDA
    plasma membrane GO:0005886 TAS
    endocytic vesicle membrane GO:0030666 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified STAB2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for STAB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SUMO3 6612
Biochemical Activity Homo sapiens
2 SUMO1 7341
Biochemical Activity Homo sapiens
3 PIAS1 8554
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which STAB2 is involved
Hyaluronan uptake and degradation TAS Reactome
Scavenging by Class H Receptors TAS Reactome

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