Gene description for FOXP2
Gene name forkhead box P2
Gene symbol FOXP2
Other names/aliases CAGH44
SPCH1
TNRC10
Species Homo sapiens
 Database cross references - FOXP2
ExoCarta ExoCarta_93986
Vesiclepedia VP_93986
Entrez Gene 93986
HGNC 13875
MIM 605317
UniProt O15409  
 FOXP2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FOXP2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    sequence-specific DNA binding GO:0043565 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    caudate nucleus development GO:0021757 IMP
    putamen development GO:0021758 IMP
    cerebral cortex development GO:0021987 IEP
    negative regulation of DNA-templated transcription GO:0045892 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified FOXP2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FOXP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRRC15 131578
Affinity Capture-MS Homo sapiens
2 SELENBP1 8991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GATAD2B 57459
Affinity Capture-Western Homo sapiens
4 FOXP2 93986
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 PHIP 55023
Affinity Capture-MS Homo sapiens
6 ELMO3 79767
Affinity Capture-MS Homo sapiens
7 CDK3 1018
Two-hybrid Homo sapiens
8 FOXP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FEV  
Proximity Label-MS Homo sapiens
10 CCNC  
Two-hybrid Homo sapiens
11 FOXP1 27086
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CTBP2 1488
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 S100A2 6273
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MAPK3 5595
Two-hybrid Homo sapiens
17 VSIG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
19 SP4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 EFHD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MKRN2 23609
Affinity Capture-RNA Homo sapiens
22 FAM124A  
Two-hybrid Homo sapiens
23 SDCBP 6386
Two-hybrid Homo sapiens
24 CTBP1 1487
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 DSG4 147409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DUSP14 11072
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PTGES3 10728
Affinity Capture-MS Homo sapiens
28 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RPIA 22934
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
30 CSNK1E 1454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 FOXP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TSACC  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PKP3 11187
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FOXP2 is involved
No pathways found





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