Gene description for PAK2
Gene name	p21 protein (Cdc42/Rac)-activated kinase 2
Gene symbol	PAK2
Other names/aliases	PAK65 PAKgamma
Species	Homo sapiens
Database cross references - PAK2
ExoCarta	ExoCarta_5062
Entrez Gene	5062
HGNC	8591
MIM	605022
UniProt	Q13177
PAK2 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for PAK2

Molecular Function     Rac GTPase binding GO:0048365 IBA     protein serine/threonine kinase activity GO:0004674 TAS     protein kinase binding GO:0019901 IPI     protein kinase activity GO:0004672 TAS     ATP binding GO:0005524 IEA     protein binding GO:0005515 IPI     protein tyrosine kinase activator activity GO:0030296 IDA     identical protein binding GO:0042802 IPI Biological Process     signal transduction GO:0007165 TAS     regulation of MAPK cascade GO:0043408 IBA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     activation of protein kinase activity GO:0032147 IBA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     programmed cell death GO:0012501 TAS     regulation of apoptotic process GO:0042981 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     T cell receptor signaling pathway GO:0050852 TAS     peptidyl-serine phosphorylation GO:0018105 IDA     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     regulation of defense response to virus by virus GO:0050690 TAS     apoptotic process GO:0006915 TAS     viral process GO:0016032 TAS     protein autophosphorylation GO:0046777 IDA     regulation of mitotic cell cycle GO:0007346 IBA     stress-activated protein kinase signaling cascade GO:0031098 IBA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     protein phosphorylation GO:0006468 IDA     small GTPase mediated signal transduction GO:0007264 TAS     phosphorylation GO:0016310 IDA     signal transduction by protein phosphorylation GO:0023014 IBA     positive regulation of protein tyrosine kinase activity GO:0061098 IDA     T cell costimulation GO:0031295 TAS     axon guidance GO:0007411 TAS     negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:2001271 IDA     innate immune response GO:0045087 TAS     negative regulation of apoptotic process GO:0043066 TAS     cell migration GO:0016477 IBA     actin cytoskeleton organization GO:0030036 IBA     regulation of growth GO:0040008 IEA     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP     negative regulation of protein kinase activity GO:0006469 TAS     Rho protein signal transduction GO:0007266 IBA Subcellular Localization     plasma membrane GO:0005886 TAS     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     perinuclear region of cytoplasm GO:0048471 IEA