Gene description for GPX1
Gene name	glutathione peroxidase 1
Gene symbol	GPX1
Other names/aliases	GPXD GSHPX1
Species	Homo sapiens
Database cross references - GPX1
ExoCarta	ExoCarta_2876
Entrez Gene	2876
HGNC	4553
MIM	138320
UniProt	P07203
GPX1 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for GPX1

Molecular Function     glutathione peroxidase activity GO:0004602 TAS     selenium binding GO:0008430 IEA     SH3 domain binding GO:0017124 IPI     phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 IEA     glutathione binding GO:0043295 IEA Biological Process     vasodilation GO:0042311 IEA     hydrogen peroxide catabolic process GO:0042744 IDA     protein oxidation GO:0018158 IEA     blood vessel endothelial cell migration GO:0043534 IEA     arachidonic acid metabolic process GO:0019369 TAS     purine nucleotide catabolic process GO:0006195 TAS     response to glucose GO:0009749 IEA     negative regulation of release of cytochrome c from mitochondria GO:0090201 IMP     heart contraction GO:0060047 IMP     regulation of neuron apoptotic process GO:0043523 IEA     cellular response to oxidative stress GO:0034599 NAS     skeletal muscle fiber development GO:0048741 IEA     response to nicotine GO:0035094 IEA     endothelial cell development GO:0001885 IEA     UV protection GO:0009650 IMP     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 IEA     response to gamma radiation GO:0010332 IEA     skeletal muscle tissue regeneration GO:0043403 IEA     cell redox homeostasis GO:0045454 IDA     response to symbiotic bacterium GO:0009609 IEA     response to xenobiotic stimulus GO:0009410 IEA     angiogenesis involved in wound healing GO:0060055 IEA     purine nucleobase metabolic process GO:0006144 TAS     glutathione metabolic process GO:0006749 IDA     lipoxygenase pathway GO:0019372 TAS     positive regulation of fibril organization GO:1902905 ISS     response to lipid hydroperoxide GO:0006982 IEA     fat cell differentiation GO:0045444 IEA     negative regulation of inflammatory response to antigenic stimulus GO:0002862 IEA     myoblast proliferation GO:0051450 IEA     nucleobase-containing small molecule metabolic process GO:0055086 TAS     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IMP     sensory perception of sound GO:0007605 IEA     interaction with symbiont GO:0051702 IEA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IMP     response to estradiol GO:0032355 IEA     temperature homeostasis GO:0001659 IEA     small molecule metabolic process GO:0044281 TAS     response to selenium ion GO:0010269 IMP     aging GO:0007568 IEA     response to toxic substance GO:0009636 IEA     response to hydrogen peroxide GO:0042542 IMP     response to folic acid GO:0051593 IEA     response to reactive oxygen species GO:0000302 TAS     positive regulation of protein kinase B signaling GO:0051897 IEA     regulation of mammary gland epithelial cell proliferation GO:0033599 IMP     triglyceride metabolic process GO:0006641 IEA     regulation of proteasomal protein catabolic process GO:0061136 IDA     regulation of gene expression, epigenetic GO:0040029 IDA Subcellular Localization     nucleus GO:0005634 IEA     extracellular exosome GO:0070062 IDA     mitochondrion GO:0005739 IDA     mitochondrial matrix GO:0005759 TAS     cytosol GO:0005829 TAS     cytoplasm GO:0005737 IDA     Lewy body GO:0097413 IDA