Gene description for ARHGAP17
Gene name Rho GTPase activating protein 17
Gene symbol ARHGAP17
Other names/aliases MST066
MST110
MSTP038
MSTP066
MSTP110
NADRIN
PP367
PP4534
RICH-1
RICH1
WBP15
Species Homo sapiens
 Database cross references - ARHGAP17
ExoCarta ExoCarta_55114
Entrez Gene 55114
HGNC 18239
MIM 608293
UniProt Q68EM7  
 ARHGAP17 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ARHGAP17
Molecular Function
    SH3 domain binding GO:0017124 IEA
    GTPase activator activity GO:0005096 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    bicellular tight junction GO:0005923 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ARHGAP17 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ARHGAP17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP10 9322
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 CDC42 998
Biochemical Activity Homo sapiens
3 CRK 1398
Reconstituted Complex Homo sapiens
4 SRC 6714
Reconstituted Complex Homo sapiens
5 FNBP1 23048
Reconstituted Complex Homo sapiens
6 PIK3R1 5295
Reconstituted Complex Homo sapiens
7 BTK 695
Reconstituted Complex Homo sapiens
8 LCK 3932
Reconstituted Complex Homo sapiens
9 ABL1 25
Reconstituted Complex Homo sapiens
10 CTTN 2017
Reconstituted Complex Homo sapiens
11 GRB2 2885
Reconstituted Complex Homo sapiens
12 SH3GLB1 51100
Reconstituted Complex Homo sapiens
13 PACSIN1  
Reconstituted Complex Homo sapiens
14 RAC1 5879
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which ARHGAP17 is involved
PathwayEvidenceSource
Rho GTPase cycle TAS Reactome





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