Gene description for WTAP
Gene name Wilms tumor 1 associated protein
Gene symbol WTAP
Other names/aliases Mum2
Species Homo sapiens
 Database cross references - WTAP
ExoCarta ExoCarta_9589
Vesiclepedia VP_9589
Entrez Gene 9589
HGNC 16846
MIM 605442
UniProt Q15007  
 WTAP identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for WTAP
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IBA
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IMP
    mRNA processing GO:0006397 IMP
    RNA splicing GO:0008380 IEA
    mRNA modification GO:0016556 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 ISS
    nuclear speck GO:0016607 IDA
    nuclear membrane GO:0031965 IDA
    RNA N6-methyladenosine methyltransferase complex GO:0036396 IDA
    RNA N6-methyladenosine methyltransferase complex GO:0036396 IPI
 Experiment description of studies that identified WTAP in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for WTAP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 KRT77 374454
Affinity Capture-MS Homo sapiens
3 SAMD9 54809
Affinity Capture-MS Homo sapiens
4 C19orf68  
Affinity Capture-MS Homo sapiens
5 SLIRP 81892
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 TNIP1 10318
Two-hybrid Homo sapiens
7 KRT6B 3854
Affinity Capture-MS Homo sapiens
8 KRT1 3848
Affinity Capture-MS Homo sapiens
9 ZNF645  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RBM15B  
Affinity Capture-MS Homo sapiens
11 CBLL1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 VSIG8  
Affinity Capture-MS Homo sapiens
13 FMR1 2332
Affinity Capture-MS Homo sapiens
14 YWHAE 7531
Affinity Capture-MS Homo sapiens
15 ALB 213
Affinity Capture-MS Homo sapiens
16 ACTC1 70
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 COL14A1 7373
Affinity Capture-MS Homo sapiens
18 BYSL 705
Two-hybrid Homo sapiens
19 LSM4 25804
Affinity Capture-MS Homo sapiens
20 TAB1 10454
Two-hybrid Homo sapiens
21 UBC 7316
Affinity Capture-MS Homo sapiens
22 CSTA 1475
Affinity Capture-MS Homo sapiens
23 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
24 PRSS3 5646
Affinity Capture-MS Homo sapiens
25 CENPA  
Co-purification Homo sapiens
26 LRPPRC 10128
Affinity Capture-MS Homo sapiens
27 KIAA1429 25962
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
28 WTAP 9589
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
29 TRIM28 10155
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
30 TFAM 7019
Affinity Capture-MS Homo sapiens
31 TCF12  
Two-hybrid Homo sapiens
32 ABHD15  
Two-hybrid Homo sapiens
33 WT1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
34 CALD1 800
Affinity Capture-MS Homo sapiens
35 PRDX2 7001
Affinity Capture-MS Homo sapiens
36 KRT5 3852
Affinity Capture-MS Homo sapiens
37 SRP14 6727
Affinity Capture-MS Homo sapiens
38 HIST4H4 121504
Affinity Capture-MS Homo sapiens
39 KRT78 196374
Affinity Capture-MS Homo sapiens
40 DYNLL1 8655
Affinity Capture-MS Homo sapiens
41 EXOSC4 54512
Two-hybrid Homo sapiens
42 ATG16L1 55054
Affinity Capture-MS Homo sapiens
43 GTSE1 51512
Two-hybrid Homo sapiens
44 MECP2 4204
Affinity Capture-MS Homo sapiens
45 MYCN  
Affinity Capture-MS Homo sapiens
46 USP7 7874
Affinity Capture-MS Homo sapiens
47 EEF1A1 1915
Affinity Capture-MS Homo sapiens
48 HSPA8 3312
Affinity Capture-MS Homo sapiens
49 SUB1 10923
Affinity Capture-MS Homo sapiens
50 MAPK1 5594
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 H2AFZ 3015
Affinity Capture-MS Homo sapiens
52 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
53 TRAPPC6A  
Affinity Capture-MS Homo sapiens
54 BRMS1 25855
Affinity Capture-MS Homo sapiens
55 KRT6A 3853
Affinity Capture-MS Homo sapiens
56 TUFM 7284
Affinity Capture-MS Homo sapiens
57 TPM4 7171
Affinity Capture-MS Homo sapiens
58 IGKV1-5 28299
Affinity Capture-MS Homo sapiens
59 KRT17 3872
Affinity Capture-MS Homo sapiens
60 UBR5 51366
Affinity Capture-MS Homo sapiens
61 TUBA1C 84790
Affinity Capture-MS Homo sapiens
62 IGHG1 3500
Affinity Capture-MS Homo sapiens
63 DDX5 1655
Affinity Capture-MS Homo sapiens
64 OGT 8473
Reconstituted Complex Homo sapiens
65 PIGB  
Affinity Capture-MS Homo sapiens
66 KRT9 3857
Affinity Capture-MS Homo sapiens
67 ZNF572  
Two-hybrid Homo sapiens
68 SNRPB2 6629
Affinity Capture-MS Homo sapiens
69 KRT14 3861
Affinity Capture-MS Homo sapiens
70 YWHAQ 10971
Reconstituted Complex Homo sapiens
71 ACTB 60
Affinity Capture-MS Homo sapiens
72 KRT2 3849
Affinity Capture-MS Homo sapiens
73 EIF4ENIF1 56478
Two-hybrid Homo sapiens
74 HECTD1 25831
Affinity Capture-MS Homo sapiens
75 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
76 DDX39B 7919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 PAICS 10606
Affinity Capture-MS Homo sapiens
78 H3F3C 440093
Affinity Capture-MS Homo sapiens
79 C1orf68 100129271
Affinity Capture-MS Homo sapiens
80 PCBP2 5094
Affinity Capture-MS Homo sapiens
81 CASP14 23581
Affinity Capture-MS Homo sapiens
82 RNF40 9810
Affinity Capture-MS Homo sapiens
83 TUBB 203068
Affinity Capture-MS Homo sapiens
84 METTL14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 AGPAT1 10554
Affinity Capture-MS Homo sapiens
86 MSH2 4436
Affinity Capture-MS Homo sapiens
87 MAGEA11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
88 SMARCA5 8467
Co-fractionation Homo sapiens
89 KRT32  
Affinity Capture-MS Homo sapiens
90 HRNR 388697
Affinity Capture-MS Homo sapiens
91 YWHAZ 7534
Affinity Capture-MS Homo sapiens
92 HSD17B10 3028
Affinity Capture-MS Homo sapiens
93 IKZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 CORO1C 23603
Affinity Capture-MS Homo sapiens
95 KRT82 3888
Affinity Capture-MS Homo sapiens
96 FN1 2335
Affinity Capture-MS Homo sapiens
97 C4A 720
Affinity Capture-MS Homo sapiens
98 PMPCB 9512
Co-fractionation Homo sapiens
99 TPM1 7168
Affinity Capture-MS Homo sapiens
100 MYC  
Affinity Capture-MS Homo sapiens
101 NME1 4830
Affinity Capture-MS Homo sapiens
102 TOP1 7150
Affinity Capture-MS Homo sapiens
103 BLMH 642
Affinity Capture-MS Homo sapiens
104 HSPA1A 3303
Affinity Capture-MS Homo sapiens
105 ANXA1 301
Affinity Capture-MS Homo sapiens
106 PRSS1 5644
Affinity Capture-MS Homo sapiens
107 HSPA7 3311
Affinity Capture-MS Homo sapiens
108 HSPA9 3313
Affinity Capture-MS Homo sapiens
109 LMNA 4000
Affinity Capture-MS Homo sapiens
110 C9orf72  
Affinity Capture-MS Homo sapiens
111 KRT16 3868
Affinity Capture-MS Homo sapiens
112 C18orf63  
Affinity Capture-MS Homo sapiens
113 TPM3 7170
Affinity Capture-MS Homo sapiens
114 DSP 1832
Affinity Capture-MS Homo sapiens
115 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
116 ZNF239  
Two-hybrid Homo sapiens
117 Sod1 20655
Affinity Capture-MS Mus musculus
118 CPSF6 11052
Affinity Capture-MS Homo sapiens
119 CA4 762
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
120 VPS52 6293
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
121 VIM 7431
Affinity Capture-MS Homo sapiens
122 KRT10 3858
Affinity Capture-MS Homo sapiens
123 PDHA1 5160
Affinity Capture-MS Homo sapiens
124 CAPZA2 830
Affinity Capture-MS Homo sapiens
125 SH3BP5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
127 THAP11 57215
Affinity Capture-MS Homo sapiens
128 RBM15 64783
Affinity Capture-MS Homo sapiens
129 FAM175A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 HNRNPK 3190
Affinity Capture-MS Homo sapiens
131 PSMA1 5682
Two-hybrid Homo sapiens
132 DCD 117159
Affinity Capture-MS Homo sapiens
133 DDX39A 10212
Affinity Capture-MS Homo sapiens
134 TXN 7295
Affinity Capture-MS Homo sapiens
135 Srsf1 110809
Affinity Capture-MS Mus musculus
136 PSMA5 5686
Affinity Capture-MS Homo sapiens
137 FLNA 2316
Affinity Capture-MS Homo sapiens
138 PRDX1 5052
Affinity Capture-MS Homo sapiens
139 DNAJB11 51726
Affinity Capture-MS Homo sapiens
140 KXD1 79036
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 METTL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
142 NCCRP1 342897
Affinity Capture-MS Homo sapiens
143 SH3GL2  
Affinity Capture-MS Homo sapiens
144 KRAS 3845
Negative Genetic Homo sapiens
145 HNRNPU 3192
Affinity Capture-MS Homo sapiens
146 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
147 ZC3H13 23091
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
148 ANXA2 302
Affinity Capture-MS Homo sapiens
149 SSRP1 6749
Affinity Capture-MS Homo sapiens
150 HSPA5 3309
Affinity Capture-MS Homo sapiens
151 FBXO38 81545
Proximity Label-MS Homo sapiens
152 ZSCAN25  
Affinity Capture-MS Homo sapiens
153 C17orf59 54785
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 FLG2 388698
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which WTAP is involved
PathwayEvidenceSource
Metabolism of RNA TAS Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome





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