Gene description for RABL6
Gene name RAB, member RAS oncogene family-like 6
Gene symbol RABL6
Other names/aliases C9orf86
PARF
RBEL1
pp8875
Species Homo sapiens
 Database cross references - RABL6
ExoCarta ExoCarta_55684
Vesiclepedia VP_55684
Entrez Gene 55684
HGNC 24703
MIM 610615
UniProt Q3YEC7  
 RABL6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RABL6
Molecular Function
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified RABL6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RABL6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP3S1 1176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
2 ATG16L1 55054
Affinity Capture-MS Homo sapiens
3 EPB41L2 2037
Co-fractionation Homo sapiens
4 SERF2 10169
Affinity Capture-MS Homo sapiens
5 RAB9A 9367
Proximity Label-MS Homo sapiens
6 ZWINT  
Affinity Capture-MS Homo sapiens
7 HNRNPC 3183
Co-fractionation Homo sapiens
8 EMC2 9694
Affinity Capture-MS Homo sapiens
9 Ercc6l  
Affinity Capture-MS Mus musculus
10 RBPMS 11030
Two-hybrid Homo sapiens
11 UBE2H 7328
Affinity Capture-MS Homo sapiens
12 ARF3 377
Proximity Label-MS Homo sapiens
13 AMTN  
Affinity Capture-MS Homo sapiens
14 LAMTOR1 55004
Proximity Label-MS Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
16 BUB1  
Affinity Capture-MS Homo sapiens
17 SMC4 10051
Co-fractionation Homo sapiens
18 RBM25 58517
Co-fractionation Homo sapiens
19 PRNP 5621
Affinity Capture-MS Homo sapiens
20 SMARCA5 8467
Co-fractionation Homo sapiens
21 RACGAP1 29127
Affinity Capture-MS Homo sapiens
22 XPO1 7514
Affinity Capture-MS Homo sapiens
23 MED29  
Co-fractionation Homo sapiens
24 MYH14 79784
Co-fractionation Homo sapiens
25 JMJD6 23210
Affinity Capture-MS Homo sapiens
26 C20orf197  
Affinity Capture-MS Homo sapiens
27 SNRNP70 6625
Co-fractionation Homo sapiens
28 EPS15 2060
Co-fractionation Homo sapiens
29 MDFI  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
30 C1orf189  
Affinity Capture-MS Homo sapiens
31 ATG9A 79065
Proximity Label-MS Homo sapiens
32 UQCRB 7381
Affinity Capture-MS Homo sapiens
33 SLC34A2 10568
Affinity Capture-MS Homo sapiens
34 LAMP2 3920
Proximity Label-MS Homo sapiens
35 CDKL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PAPD5 64282
Affinity Capture-MS Homo sapiens
37 PRPF40A 55660
Co-fractionation Homo sapiens
38 GBF1 8729
Co-fractionation Homo sapiens
39 PLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PEG10 23089
Affinity Capture-MS Homo sapiens
41 NAF1  
Affinity Capture-MS Homo sapiens
42 POLR3K  
Affinity Capture-MS Homo sapiens
43 CCDC71  
Affinity Capture-MS Homo sapiens
44 MTA2 9219
Co-fractionation Homo sapiens
45 ZNF684  
Affinity Capture-MS Homo sapiens
46 NXF1 10482
Affinity Capture-RNA Homo sapiens
47 CDC42 998
Affinity Capture-MS Homo sapiens
48 RAB4A 5867
Proximity Label-MS Homo sapiens
49 TMA16  
Affinity Capture-MS Homo sapiens
50 RAB5A 5868
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
51 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
52 LOC338797  
Affinity Capture-MS Homo sapiens
53 RAB11A 8766
Proximity Label-MS Homo sapiens
54 PPP1R12A 4659
Co-fractionation Homo sapiens
55 PDILT  
Affinity Capture-MS Homo sapiens
56 MOV10 4343
Affinity Capture-RNA Homo sapiens
57 RPA3 6119
Proximity Label-MS Homo sapiens
58 SREK1IP1  
Affinity Capture-MS Homo sapiens
59 RNF43  
Proximity Label-MS Homo sapiens
60 NTRK1 4914
Affinity Capture-MS Homo sapiens
61 BRCC3 79184
Co-fractionation Homo sapiens
62 DLST 1743
Affinity Capture-MS Homo sapiens
63 CLTA 1211
Proximity Label-MS Homo sapiens
64 CHST15 51363
Affinity Capture-MS Homo sapiens
65 Mis12  
Affinity Capture-MS Mus musculus
66 EP300 2033
Affinity Capture-MS Homo sapiens
67 SPINK7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 COG3 83548
Co-fractionation Homo sapiens
69 Bub1b 12236
Affinity Capture-MS Mus musculus
70 PARP1 142
Affinity Capture-MS Homo sapiens
71 MYH10 4628
Co-fractionation Homo sapiens
72 CALCOCO2  
Two-hybrid Homo sapiens
73 CTR9 9646
Co-fractionation Homo sapiens
74 NUP85 79902
Co-fractionation Homo sapiens
75 MTUS2 23281
Affinity Capture-MS Homo sapiens
76 C19orf57  
Two-hybrid Homo sapiens
77 KLK12  
Affinity Capture-MS Homo sapiens
78 MYL12A 10627
Co-fractionation Homo sapiens
79 MDM2  
Affinity Capture-Western Homo sapiens
80 DAXX  
Affinity Capture-MS Homo sapiens
81 STX6 10228
Proximity Label-MS Homo sapiens
82 PSMD3 5709
Co-fractionation Homo sapiens
83 ID2  
Affinity Capture-MS Homo sapiens
84 AP3M1 26985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which RABL6 is involved
No pathways found





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