Gene description for ARNT
Gene name aryl hydrocarbon receptor nuclear translocator
Gene symbol ARNT
Other names/aliases HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
Species Homo sapiens
 Database cross references - ARNT
ExoCarta ExoCarta_405
Vesiclepedia VP_405
Entrez Gene 405
HGNC 700
MIM 126110
UniProt P27540  
 ARNT identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ARNT
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    nuclear receptor activity GO:0004879 IDA
    protein binding GO:0005515 IPI
    aryl hydrocarbon receptor binding GO:0017162 IPI
    protein homodimerization activity GO:0042803 IDA
    sequence-specific DNA binding GO:0043565 IDA
    protein heterodimerization activity GO:0046982 IDA
    protein heterodimerization activity GO:0046982 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    response to hypoxia GO:0001666 IDA
    embryonic placenta development GO:0001892 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IC
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of vascular endothelial growth factor production GO:0010575 IDA
    cell differentiation GO:0030154 IEA
    intracellular receptor signaling pathway GO:0030522 IEA
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IC
    positive regulation of protein sumoylation GO:0033235 IEA
    cellular response to oxidative stress GO:0034599 IDA
    positive regulation of erythrocyte differentiation GO:0045648 IC
    positive regulation of glycolytic process GO:0045821 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of hormone biosynthetic process GO:0046886 IDA
    negative regulation of inflammatory response GO:0050728 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IEA
    nuclear body GO:0016604 IDA
    aryl hydrocarbon receptor complex GO:0034751 IBA
    nuclear aryl hydrocarbon receptor complex GO:0034753 IDA
    RNA polymerase II transcription regulator complex GO:0090575 IDA
 Experiment description of studies that identified ARNT in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ARNT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2F1 2962
Reconstituted Complex Homo sapiens
2 SELENBP1 8991
Affinity Capture-MS Homo sapiens
3 GMNN  
Two-hybrid Homo sapiens
4 TCEB1 6921
Affinity Capture-MS Homo sapiens
5 FEV  
Proximity Label-MS Homo sapiens
6 AHRR 57491
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 ARPC2 10109
Affinity Capture-MS Homo sapiens
8 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
9 SP1  
Reconstituted Complex Homo sapiens
10 Tacc3 21335
Reconstituted Complex Mus musculus
11 BRCA1 672
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CAND1 55832
Affinity Capture-MS Homo sapiens
14 OR6K3  
Affinity Capture-MS Homo sapiens
15 RTN4 57142
Affinity Capture-MS Homo sapiens
16 SOX2  
Proximity Label-MS Homo sapiens
17 RPL4 6124
Affinity Capture-MS Homo sapiens
18 RUVBL1 8607
Affinity Capture-MS Homo sapiens
19 TRIM28 10155
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
20 DPM1 8813
Affinity Capture-MS Homo sapiens
21 TIMM8A 1678
Affinity Capture-MS Homo sapiens
22 GTF2F2 2963
Reconstituted Complex Homo sapiens
23 HEY1  
Two-hybrid Homo sapiens
24 NUP35 129401
Proximity Label-MS Homo sapiens
25 FOXR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 S100A9 6280
Affinity Capture-MS Homo sapiens
27 MYO1B 4430
Affinity Capture-MS Homo sapiens
28 NCOA7  
Reconstituted Complex Homo sapiens
29 SFN 2810
Affinity Capture-MS Homo sapiens
30 ZSCAN18  
Affinity Capture-MS Homo sapiens
31 TNS3 64759
Affinity Capture-MS Homo sapiens
32 NPAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ASF1A 25842
Proximity Label-MS Homo sapiens
34 FEM1A  
Affinity Capture-MS Homo sapiens
35 MAD2L1 4085
Affinity Capture-MS Homo sapiens
36 RPL19 6143
Affinity Capture-MS Homo sapiens
37 MYL6 4637
Affinity Capture-MS Homo sapiens
38 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ADSL 158
Affinity Capture-MS Homo sapiens
40 NCOA1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
41 RB1 5925
Affinity Capture-Western Homo sapiens
42 LRRC59 55379
Affinity Capture-MS Homo sapiens
43 RPL27 6155
Affinity Capture-MS Homo sapiens
44 PPP1CA 5499
Affinity Capture-MS Homo sapiens
45 IRAK4 51135
Two-hybrid Homo sapiens
46 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
47 NARFL 64428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KLC1 3831
Affinity Capture-MS Homo sapiens
49 SHMT1 6470
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 NCOR2  
Reconstituted Complex Homo sapiens
51 GNAI1 2770
Affinity Capture-MS Homo sapiens
52 NONO 4841
Affinity Capture-MS Homo sapiens
53 HEY2  
Two-hybrid Homo sapiens
54 SIM2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
55 DIABLO 56616
Two-hybrid Homo sapiens
56 FYN 2534
Affinity Capture-MS Homo sapiens
57 PSMD2 5708
Affinity Capture-MS Homo sapiens
58 NDOR1  
Affinity Capture-MS Homo sapiens
59 SLX1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PIAS2  
Affinity Capture-Western Homo sapiens
61 ARNT 405
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
62 AIP 9049
Reconstituted Complex Homo sapiens
63 PML 5371
Reconstituted Complex Homo sapiens
64 PRKDC 5591
Co-localization Homo sapiens
65 GNAI2 2771
Affinity Capture-MS Homo sapiens
66 CUL2 8453
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
67 FLOT2 2319
Affinity Capture-MS Homo sapiens
68 CEBPA  
Proximity Label-MS Homo sapiens
69 GIP  
Affinity Capture-MS Homo sapiens
70 Clock  
Two-hybrid Mus musculus
71 CNBP 7555
Affinity Capture-MS Homo sapiens
72 CALML3 810
Affinity Capture-MS Homo sapiens
73 C1QTNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ADH5 128
Two-hybrid Homo sapiens
75 TMPO 7112
Affinity Capture-MS Homo sapiens
76 LSM8 51691
Two-hybrid Homo sapiens
77 NPAS3  
Affinity Capture-MS Homo sapiens
78 NPAS4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
79 CDK9 1025
Affinity Capture-MS Homo sapiens
80 SOX6  
Proximity Label-MS Homo sapiens
81 BAG2 9532
Affinity Capture-MS Homo sapiens
82 SMARCA5 8467
Affinity Capture-MS Homo sapiens
83 EPAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
84 PPA1 5464
Affinity Capture-MS Homo sapiens
85 CTNNB1 1499
Affinity Capture-MS Homo sapiens
86 S100A8 6279
Affinity Capture-MS Homo sapiens
87 CTTN 2017
Affinity Capture-MS Homo sapiens
88 EGFR 1956
Negative Genetic Homo sapiens
89 RPL7 6129
Affinity Capture-MS Homo sapiens
90 VHL  
Affinity Capture-MS Homo sapiens
91 MYO1C 4641
Affinity Capture-MS Homo sapiens
92 JUN 3725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 SLC25A11 8402
Affinity Capture-MS Homo sapiens
94 GNAS 2778
Affinity Capture-MS Homo sapiens
95 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
96 RPA3 6119
Proximity Label-MS Homo sapiens
97 SMAD9  
Two-hybrid Homo sapiens
98 C22orf29  
Affinity Capture-MS Homo sapiens
99 AHR 196
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
100 RPL35A 6165
Affinity Capture-MS Homo sapiens
101 HSPA1A 3303
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 TCEB2 6923
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
103 MATR3 9782
Affinity Capture-MS Homo sapiens
104 RPL18 6141
Affinity Capture-MS Homo sapiens
105 RANBP1 5902
Affinity Capture-MS Homo sapiens
106 DCAF15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 HSPD1 3329
Affinity Capture-MS Homo sapiens
108 SYT7  
Affinity Capture-MS Homo sapiens
109 NANOG  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 Ostm1  
Affinity Capture-MS Mus musculus
111 Nr0b2  
Reconstituted Complex Mus musculus
112 HIF1A 3091
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
113 TUBB2A 7280
Reconstituted Complex Homo sapiens
114 SUGT1 10910
Affinity Capture-MS Homo sapiens
115 Cebpa  
Reconstituted Complex Rattus norvegicus
Two-hybrid Rattus norvegicus
116 FASN 2194
Positive Genetic Homo sapiens
117 DNM2 1785
Affinity Capture-MS Homo sapiens
118 JUP 3728
Affinity Capture-Western Homo sapiens
119 HMGB1 3146
Affinity Capture-MS Homo sapiens
120 SIM1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
121 RUVBL2 10856
Affinity Capture-MS Homo sapiens
122 XRCC6 2547
Affinity Capture-MS Homo sapiens
123 TNFAIP1 7126
Two-hybrid Homo sapiens
124 DNAJA2 10294
Affinity Capture-MS Homo sapiens
125 IKBKG 8517
Affinity Capture-Western Homo sapiens
126 HIF3A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 NCOA2 10499
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
128 HSPB1 3315
Affinity Capture-MS Homo sapiens
129 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
130 HDAC1 3065
Affinity Capture-MS Homo sapiens
131 CHD4 1108
Affinity Capture-Western Homo sapiens
132 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
133 LYN 4067
Affinity Capture-MS Homo sapiens
134 FOXN1  
Affinity Capture-MS Homo sapiens
135 CREB1  
Affinity Capture-MS Homo sapiens
136 RPS5 6193
Affinity Capture-MS Homo sapiens
137 TRIP11 9321
Reconstituted Complex Homo sapiens
138 ESR1  
Reconstituted Complex Homo sapiens
139 MPRIP 23164
Affinity Capture-MS Homo sapiens
140 PAX7  
Proximity Label-MS Homo sapiens
141 CAD 790
Affinity Capture-MS Homo sapiens
142 PXN 5829
Affinity Capture-MS Homo sapiens
143 PCCB 5096
Affinity Capture-MS Homo sapiens
144 TNNC2  
Affinity Capture-MS Homo sapiens
145 SHARPIN  
Affinity Capture-MS Homo sapiens
146 MTA3 57504
Two-hybrid Homo sapiens
147 PTGES3 10728
Reconstituted Complex Homo sapiens
148 KRAS 3845
Affinity Capture-MS Homo sapiens
149 LOX 4015
Affinity Capture-MS Homo sapiens
150 RAC1 5879
Affinity Capture-MS Homo sapiens
151 SP7  
Proximity Label-MS Homo sapiens
152 STRBP 55342
Two-hybrid Homo sapiens
153 BCAT1 586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 EP300 2033
Affinity Capture-Western Homo sapiens
155 SIPA1L3  
Affinity Capture-MS Homo sapiens
156 HSPA2 3306
Affinity Capture-MS Homo sapiens
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