Gene description for KRT31
Gene name keratin 31, type I
Gene symbol KRT31
Other names/aliases HA1
Ha-1
KRTHA1
hHa1
Species Homo sapiens
 Database cross references - KRT31
ExoCarta ExoCarta_3881
Vesiclepedia VP_3881
Entrez Gene 3881
HGNC 6448
MIM 601077
UniProt Q15323  
 KRT31 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Hepatocellular carcinoma cells 26054723    
Prostate cancer cells 25844599    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for KRT31
Molecular Function
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
Biological Process
    epidermis development GO:0008544 TAS
    epithelial cell differentiation GO:0030855 IBA
    intermediate filament organization GO:0045109 IBA
Subcellular Localization
    extracellular space GO:0005615 HDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT31 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
5
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
6
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRT31
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTP1 2950
Two-hybrid Homo sapiens
2 COX5A 9377
Two-hybrid Homo sapiens
3 Mrpl13  
Two-hybrid Mus musculus
4 SLIRP 81892
Two-hybrid Homo sapiens
5 GNG10 2790
Two-hybrid Homo sapiens
6 CEP57L1  
Two-hybrid Homo sapiens
7 BIRC6 57448
Affinity Capture-MS Homo sapiens
8 DGCR14  
Two-hybrid Homo sapiens
9 TWF2 11344
Affinity Capture-MS Homo sapiens
10 CRH  
Two-hybrid Homo sapiens
11 Nhp2l1 20826
Two-hybrid Mus musculus
12 KRT6B 3854
Two-hybrid Homo sapiens
13 KRT77 374454
Two-hybrid Homo sapiens
14 ZNF124  
Two-hybrid Homo sapiens
15 RBM22 55696
Two-hybrid Homo sapiens
16 TRAF4 9618
Two-hybrid Homo sapiens
17 ATG9A 79065
Two-hybrid Homo sapiens
18 KIFC3 3801
Two-hybrid Homo sapiens
19 PKP2 5318
Two-hybrid Homo sapiens
20 KRT6A 3853
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 ZFP1  
Affinity Capture-MS Homo sapiens
22 CARD9 64170
Two-hybrid Homo sapiens
23 RADIL  
Two-hybrid Homo sapiens
24 HSPA12B 116835
Two-hybrid Homo sapiens
25 TSG101 7251
Two-hybrid Homo sapiens
26 SMARCE1 6605
Two-hybrid Homo sapiens
27 BYSL 705
Two-hybrid Homo sapiens
28 CDC25B 994
Affinity Capture-MS Homo sapiens
29 P2RX7 5027
Two-hybrid Homo sapiens
30 CD33 945
Two-hybrid Homo sapiens
31 TTC23  
Two-hybrid Homo sapiens
32 DHX57 90957
Two-hybrid Homo sapiens
33 UNKL  
Two-hybrid Homo sapiens
34 ATN1  
Two-hybrid Homo sapiens
35 EXOSC7 23016
Two-hybrid Homo sapiens
36 EIF4E2  
Two-hybrid Homo sapiens
37 FNTA 2339
Affinity Capture-MS Homo sapiens
38 LINC00526  
Two-hybrid Homo sapiens
39 ARMC7  
Two-hybrid Homo sapiens
40 PPP1R18 170954
Two-hybrid Homo sapiens
41 Mrps21  
Two-hybrid Mus musculus
42 EIF4ENIF1 56478
Two-hybrid Homo sapiens
43 ATXN7L1 222255
Two-hybrid Homo sapiens
44 DGKB  
Affinity Capture-MS Homo sapiens
45 INA 9118
Affinity Capture-MS Homo sapiens
46 SMG9 56006
Two-hybrid Homo sapiens
47 ZMAT5  
Two-hybrid Homo sapiens
48 CEP70  
Two-hybrid Homo sapiens
49 DMRT3  
Two-hybrid Homo sapiens
50 SMCP  
Two-hybrid Homo sapiens
51 CARKD 55739
Two-hybrid Homo sapiens
52 EFNA4  
Affinity Capture-MS Homo sapiens
53 NAV1 89796
Two-hybrid Homo sapiens
54 CHCHD2  
Two-hybrid Homo sapiens
55 LENG1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 TMEM231 79583
Two-hybrid Homo sapiens
57 ZNF148  
Two-hybrid Homo sapiens
58 HGS 9146
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
59 CPSF7 79869
Two-hybrid Homo sapiens
60 SUV39H1  
Two-hybrid Homo sapiens
61 SNRPC 6631
Two-hybrid Homo sapiens
62 Mrps31  
Two-hybrid Mus musculus
63 YWHAG 7532
Affinity Capture-MS Homo sapiens
64 ZNF569  
Two-hybrid Homo sapiens
65 SEMA4C 54910
Two-hybrid Homo sapiens
66 KRT5 3852
Two-hybrid Homo sapiens
67 MACROD1 28992
Affinity Capture-MS Homo sapiens
68 Tsnax  
Two-hybrid Mus musculus
69 ZNF20  
Two-hybrid Homo sapiens
70 KLC4 89953
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
71 COMT 1312
Two-hybrid Homo sapiens
72 ICAM4  
Two-hybrid Homo sapiens
73 Ndel1  
Two-hybrid Mus musculus
74 KRT83  
Two-hybrid Homo sapiens
75 TIAL1 7073
Two-hybrid Homo sapiens
76 LONRF1  
Two-hybrid Homo sapiens
77 MARK4  
Two-hybrid Homo sapiens
78 OTUB2  
Two-hybrid Homo sapiens
79 PKN3 29941
Affinity Capture-MS Homo sapiens
80 CEP63  
Affinity Capture-MS Homo sapiens
81 FBF1  
Two-hybrid Homo sapiens
82 RCOR3  
Two-hybrid Homo sapiens
83 FBXW5  
Two-hybrid Homo sapiens
84 FKBP1B  
Two-hybrid Homo sapiens
85 CDC20B  
Two-hybrid Homo sapiens
86 C1orf216  
Two-hybrid Homo sapiens
87 TMEM106C 79022
Two-hybrid Homo sapiens
88 Igf2bp1  
Two-hybrid Mus musculus
89 TXLNG  
Affinity Capture-MS Homo sapiens
90 KRT8 3856
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
91 FARS2 10667
Two-hybrid Homo sapiens
92 PRPF6 24148
Two-hybrid Homo sapiens
93 AQP1 358
Two-hybrid Homo sapiens
94 UTP14A 10813
Two-hybrid Homo sapiens
95 Klc4  
Two-hybrid Mus musculus
96 SPATA24  
Two-hybrid Homo sapiens
97 CEP55 55165
Two-hybrid Homo sapiens
98 UXT 8409
Two-hybrid Homo sapiens
99 FAM71C  
Two-hybrid Homo sapiens
100 CDKN1A  
Two-hybrid Homo sapiens
101 ASMTL 8623
Two-hybrid Homo sapiens
102 KLC1 3831
Two-hybrid Homo sapiens
103 GAN 8139
Affinity Capture-MS Homo sapiens
104 FAM110A  
Two-hybrid Homo sapiens
105 BFSP1  
Affinity Capture-MS Homo sapiens
106 SNRNP25  
Two-hybrid Homo sapiens
107 RBM7  
Two-hybrid Homo sapiens
108 AES 166
Two-hybrid Homo sapiens
109 RPL5 6125
Two-hybrid Homo sapiens
110 DGCR6L  
Two-hybrid Homo sapiens
111 PSMG2 56984
Two-hybrid Homo sapiens
112 PLEKHB2 55041
Affinity Capture-MS Homo sapiens
113 USP8 9101
Affinity Capture-MS Homo sapiens
114 C12orf49  
Two-hybrid Homo sapiens
115 SNRPB 6628
Two-hybrid Homo sapiens
116 GEM  
Two-hybrid Homo sapiens
117 SLAIN1 122060
Two-hybrid Homo sapiens
118 WDYHV1  
Two-hybrid Homo sapiens
119 DTNB 1838
Two-hybrid Homo sapiens
120 ZNF572  
Two-hybrid Homo sapiens
121 EXOSC5 56915
Two-hybrid Homo sapiens
122 C17orf70  
Affinity Capture-MS Homo sapiens
123 ALDH3B1 221
Two-hybrid Homo sapiens
124 PATL1 219988
Two-hybrid Homo sapiens
125 PKN1 5585
Two-hybrid Homo sapiens
126 LMF2 91289
Two-hybrid Homo sapiens
127 LYAR 55646
Affinity Capture-MS Homo sapiens
128 KRT2 3849
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
129 SLC15A3  
Two-hybrid Homo sapiens
130 GNAI2 2771
Two-hybrid Homo sapiens
131 FAM124B  
Two-hybrid Homo sapiens
132 DDX39B 7919
Affinity Capture-MS Homo sapiens
133 TXNL4A 10907
Two-hybrid Homo sapiens
134 GNG5 2787
Two-hybrid Homo sapiens
135 ARSJ  
Two-hybrid Homo sapiens
136 Ptcd2 68927
Two-hybrid Mus musculus
137 C6orf165  
Two-hybrid Homo sapiens
138 SLC23A1 9963
Two-hybrid Homo sapiens
139 GPS2  
Two-hybrid Homo sapiens
140 TROAP  
Two-hybrid Homo sapiens
141 Nufip2  
Two-hybrid Mus musculus
142 PRR19  
Two-hybrid Homo sapiens
143 TXLNA 200081
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
144 MRPL44  
Two-hybrid Homo sapiens
145 SFPQ 6421
Two-hybrid Homo sapiens
146 CEP57  
Two-hybrid Homo sapiens
147 MRPL40 64976
Two-hybrid Homo sapiens
148 COX5B 1329
Two-hybrid Homo sapiens
149 MAZ 4150
Two-hybrid Homo sapiens
150 PGLS 25796
Two-hybrid Homo sapiens
151 Mbp 17196
Two-hybrid Mus musculus
152 SF1 7536
Two-hybrid Homo sapiens
153 CATIP  
Two-hybrid Homo sapiens
154 LINC00238  
Two-hybrid Homo sapiens
155 CCNC  
Two-hybrid Homo sapiens
156 TAPBPL 55080
Two-hybrid Homo sapiens
157 USP15 9958
Affinity Capture-MS Homo sapiens
158 RC3H2  
Affinity Capture-MS Homo sapiens
159 MRPS11  
Two-hybrid Homo sapiens
160 CCDC120  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
161 TRIP6 7205
Affinity Capture-MS Homo sapiens
162 PRKAA2 5563
Two-hybrid Homo sapiens
163 MAPKBP1  
Two-hybrid Homo sapiens
164 WDR25  
Two-hybrid Homo sapiens
165 SIRPA 140885
Two-hybrid Homo sapiens
166 EPPK1 83481
Affinity Capture-MS Homo sapiens
167 Rbm14  
Two-hybrid Mus musculus
168 CUL3 8452
Affinity Capture-MS Homo sapiens
169 NEFM 4741
Affinity Capture-MS Homo sapiens
170 SPECC1 92521
Affinity Capture-MS Homo sapiens
171 ZC3H8  
Two-hybrid Homo sapiens
172 AMOT  
Two-hybrid Homo sapiens
173 FAM90A1  
Two-hybrid Homo sapiens
174 SYCE2  
Affinity Capture-MS Homo sapiens
175 FAM74A4  
Two-hybrid Homo sapiens
176 HOXA1 3198
Two-hybrid Homo sapiens
177 DHX37  
Two-hybrid Homo sapiens
178 NPBWR2  
Two-hybrid Homo sapiens
179 FN1 2335
Affinity Capture-MS Homo sapiens
180 NXF1 10482
Two-hybrid Homo sapiens
181 HOOK3 84376
Affinity Capture-MS Homo sapiens
182 AMOTL2 51421
Two-hybrid Homo sapiens
183 CTSG 1511
Two-hybrid Homo sapiens
184 PLS1 5357
Affinity Capture-MS Homo sapiens
185 PRR3  
Two-hybrid Homo sapiens
186 UBR1 197131
Affinity Capture-MS Homo sapiens
187 Dusp14  
Two-hybrid Mus musculus
188 BEX2  
Two-hybrid Homo sapiens
189 PSPC1 55269
Two-hybrid Homo sapiens
190 AGR2 10551
Two-hybrid Homo sapiens
191 GLRX3 10539
Two-hybrid Homo sapiens
192 ZFYVE21  
Two-hybrid Homo sapiens
193 RIBC1  
Two-hybrid Homo sapiens
194 C14orf80  
Affinity Capture-MS Homo sapiens
195 SRSF2 6427
Two-hybrid Homo sapiens
196 DNPEP 23549
Affinity Capture-MS Homo sapiens
197 ZER1 10444
Affinity Capture-MS Homo sapiens
198 FNTB 2342
Affinity Capture-MS Homo sapiens
199 LCE4A  
Two-hybrid Homo sapiens
200 USHBP1  
Two-hybrid Homo sapiens
201 PTPMT1 114971
Two-hybrid Homo sapiens
202 SHC3  
Two-hybrid Homo sapiens
203 GNE 10020
Two-hybrid Homo sapiens
204 HSPD1 3329
Two-hybrid Homo sapiens
205 INPP5D 3635
Two-hybrid Homo sapiens
206 MAP3K7CL  
Two-hybrid Homo sapiens
207 ALS2CR11  
Two-hybrid Homo sapiens
208 BAG4  
Two-hybrid Homo sapiens
209 FAM103A1  
Two-hybrid Homo sapiens
210 LMO4  
Two-hybrid Homo sapiens
211 ANKRD36BP1  
Two-hybrid Homo sapiens
212 CLDN2 9075
Two-hybrid Homo sapiens
213 CALCOCO1 57658
Affinity Capture-MS Homo sapiens
214 ALG13 79868
Two-hybrid Homo sapiens
215 TCEAL8  
Affinity Capture-MS Homo sapiens
216 CA6 765
Two-hybrid Homo sapiens
217 GRN 2896
Two-hybrid Homo sapiens
218 CDC20 991
Affinity Capture-MS Homo sapiens
219 BCAS2 10286
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
220 SLC25A6 293
Two-hybrid Homo sapiens
221 SNAI1  
Two-hybrid Homo sapiens
222 HAUS1  
Two-hybrid Homo sapiens
223 KLHL38  
Two-hybrid Homo sapiens