Gene description for PRKAA2
Gene name	protein kinase, AMP-activated, alpha 2 catalytic subunit
Gene symbol	PRKAA2
Other names/aliases	AMPK AMPK2 AMPKa2 PRKAA
Species	Homo sapiens
Database cross references - PRKAA2
ExoCarta	ExoCarta_5563
Vesiclepedia	VP_5563
Entrez Gene	5563
HGNC	9377
MIM	600497
UniProt	P54646
PRKAA2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for PRKAA2

Molecular Function     chromatin binding GO:0003682 ISS     protein kinase activity GO:0004672 TAS     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 ISS     protein serine/threonine kinase activity GO:0004674 TAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IDA     AMP-activated protein kinase activity GO:0004679 ISS     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein serine/threonine/tyrosine kinase activity GO:0004712 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     metal ion binding GO:0046872 IEA     [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity GO:0047322 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 ISS     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 TAS     fatty acid biosynthetic process GO:0006633 IEA     cholesterol biosynthetic process GO:0006695 IEA     autophagy GO:0006914 IEA     signal transduction GO:0007165 TAS     lipid biosynthetic process GO:0008610 ISS     positive regulation of autophagy GO:0010508 ISS     negative regulation of gene expression GO:0010629 ISS     response to muscle activity GO:0014850 IEA     Wnt signaling pathway GO:0016055 IEA     positive regulation of macroautophagy GO:0016239 TAS     regulation of macroautophagy GO:0016241 ISS     cellular response to nutrient levels GO:0031669 IDA     cellular response to nutrient levels GO:0031669 ISS     cellular response to nutrient levels GO:0031669 NAS     negative regulation of TOR signaling GO:0032007 IBA     negative regulation of TOR signaling GO:0032007 ISS     cellular response to oxidative stress GO:0034599 ISS     cellular response to glucose starvation GO:0042149 IBA     cellular response to glucose starvation GO:0042149 IDA     glucose homeostasis GO:0042593 ISS     regulation of circadian rhythm GO:0042752 ISS     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of glycolytic process GO:0045821 ISS     rhythmic process GO:0048511 IEA     fatty acid homeostasis GO:0055089 ISS     regulation of stress granule assembly GO:0062028 IEA     regulation of microtubule cytoskeleton organization GO:0070507 ISS     cellular response to calcium ion GO:0071277 ISS     cellular response to glucose stimulus GO:0071333 ISS     cellular response to prostaglandin E stimulus GO:0071380 IEA     cellular response to xenobiotic stimulus GO:0071466 IEA     energy homeostasis GO:0097009 ISS     positive regulation of protein localization GO:1903829 ISS     negative regulation of hepatocyte apoptotic process GO:1903944 IDA     negative regulation of TORC1 signaling GO:1904262 IDA     negative regulation of tubulin deacetylation GO:1904428 ISS     lipid droplet disassembly GO:1905691 IDA     protein localization to lipid droplet GO:1990044 IDA     positive regulation of peptidyl-lysine acetylation GO:2000758 ISS Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 TAS     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 TAS     cytoplasmic stress granule GO:0010494 ISS     nuclear speck GO:0016607 IDA     axon GO:0030424 ISS     dendrite GO:0030425 ISS     nucleotide-activated protein kinase complex GO:0031588 IBA     nucleotide-activated protein kinase complex GO:0031588 IPI     nucleotide-activated protein kinase complex GO:0031588 ISS     neuronal cell body GO:0043025 ISS