Gene description for COMP
Gene name cartilage oligomeric matrix protein
Gene symbol COMP
Other names/aliases EDM1
Species Homo sapiens
 Database cross references - COMP
ExoCarta ExoCarta_1311
Entrez Gene 1311
HGNC 2227
MIM 600310
UniProt P49747  
 COMP identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Prostate cancer cells 25844599    
 Gene ontology annotations for COMP
Molecular Function
    extracellular matrix structural constituent GO:0005201 IEA
    calcium ion binding GO:0005509 IDA
    collagen binding GO:0005518 IDA
    protein binding GO:0005515 IPI
    heparan sulfate proteoglycan binding GO:0043395 IDA
    protease binding GO:0002020 IPI
    heparin binding GO:0008201 IDA
Biological Process
    growth plate cartilage development GO:0003417 IEA
    extracellular matrix organization GO:0030198 TAS
    limb development GO:0060173 IDA
    organ morphogenesis GO:0009887 TAS
    cell adhesion GO:0007155 IEA
    apoptotic process GO:0006915 IEA
    skeletal system development GO:0001501 TAS
    negative regulation of apoptotic process GO:0043066 IDA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular matrix GO:0031012 IDA
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified COMP in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for COMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COL2A1 1280
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which COMP is involved
ECM proteoglycans TAS Reactome
Integrin cell surface interactions TAS Reactome

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