Gene description for ACTR8
Gene name ARP8 actin-related protein 8 homolog (yeast)
Gene symbol ACTR8
Other names/aliases ARP8
INO80N
hArp8
Species Homo sapiens
 Database cross references - ACTR8
ExoCarta ExoCarta_93973
Vesiclepedia VP_93973
Entrez Gene 93973
HGNC 14672
UniProt Q9H981  
 ACTR8 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ACTR8
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    telomere maintenance GO:0000723 ISO
    regulation of DNA replication GO:0006275 IMP
    regulation of DNA repair GO:0006282 ISO
    double-strand break repair GO:0006302 IBA
    DNA recombination GO:0006310 IEA
    chromatin remodeling GO:0006338 IDA
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of chromosome organization GO:0033044 IMP
    positive regulation of DNA repair GO:0045739 ISO
    positive regulation of DNA-templated transcription GO:0045893 IMP
    regulation of embryonic development GO:0045995 ISO
    cell division GO:0051301 IEA
    regulation of cell cycle GO:0051726 IMP
    regulation of DNA strand elongation GO:0060382 IMP
    positive regulation of telomere maintenance in response to DNA damage GO:1904507 ISO
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    centrosome GO:0005813 IDA
    Ino80 complex GO:0031011 IBA
    Ino80 complex GO:0031011 IDA
 Experiment description of studies that identified ACTR8 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACTR8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SENP3 26168
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 Ruvbl2 20174
Affinity Capture-MS Mus musculus
5 NPAS1  
Affinity Capture-MS Homo sapiens
6 PRKY  
Affinity Capture-MS Homo sapiens
7 Ruvbl1 56505
Affinity Capture-MS Mus musculus
8 ACTL6A 86
Affinity Capture-MS Homo sapiens
9 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 GTF2I 2969
Affinity Capture-MS Homo sapiens
11 AMY1C 278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 BRD2  
Affinity Capture-MS Homo sapiens
13 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
14 NFRKB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
15 YY1 7528
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TFPT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 METTL21B  
Affinity Capture-MS Homo sapiens
18 BRD3 8019
Affinity Capture-MS Homo sapiens
19 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
20 PAX6  
Proximity Label-MS Homo sapiens
21 BAG6 7917
Affinity Capture-MS Homo sapiens
22 INO80C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 APEX1 328
Affinity Capture-RNA Homo sapiens
24 SGTB  
Affinity Capture-MS Homo sapiens
25 RUVBL1 8607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ACTR5 79913
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
27 DNAI2  
Affinity Capture-MS Homo sapiens
28 BCL7C  
Affinity Capture-MS Homo sapiens
29 NT5C 30833
Affinity Capture-MS Homo sapiens
30 KLF8  
Proximity Label-MS Homo sapiens
31 INO80B 83444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 INO80D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 INO80  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
34 Cep78  
Affinity Capture-MS Mus musculus
35 ACTR8 93973
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
36 DCAF10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PRC1 9055
Affinity Capture-MS Homo sapiens
38 ACTB 60
Affinity Capture-MS Homo sapiens
39 LGI1  
Affinity Capture-MS Homo sapiens
40 ELF4 2000
Proximity Label-MS Homo sapiens
41 CCT8L2  
Affinity Capture-MS Homo sapiens
42 BCL7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 INO80E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 UBXN6 80700
Affinity Capture-MS Homo sapiens
45 UCHL5 51377
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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