Gene description for KRT73
Gene name keratin 73, type II
Gene symbol KRT73
Other names/aliases IRT6IRS3
K6IRS3
KRT6IRS3
Species Homo sapiens
 Database cross references - KRT73
ExoCarta ExoCarta_319101
Vesiclepedia VP_319101
Entrez Gene 319101
HGNC 28928
MIM 608247
UniProt Q86Y46  
 KRT73 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Saliva 19199708    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for KRT73
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of skin epidermis GO:0030280 IBA
Biological Process
    keratinization GO:0031424 IBA
    intermediate filament organization GO:0045109 IBA
Subcellular Localization
    nucleus GO:0005634 HDA
    cytosol GO:0005829 TAS
    keratin filament GO:0045095 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT73 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
4
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRT73
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT84 3890
Cross-Linking-MS (XL-MS) Homo sapiens
2 GAN 8139
Affinity Capture-MS Homo sapiens
3 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
4 EFNA4  
Affinity Capture-MS Homo sapiens
5 CCNB2  
Affinity Capture-MS Homo sapiens
6 Smc1a  
Affinity Capture-MS Mus musculus
7 GRB2 2885
Affinity Capture-MS Homo sapiens
8 KRT36 8689
Two-hybrid Homo sapiens
9 Tmed10 68581
Affinity Capture-MS Mus musculus
10 SLC1A1 6505
Affinity Capture-MS Homo sapiens
11 INPPL1 3636
Affinity Capture-MS Homo sapiens
12 KRT6A 3853
Cross-Linking-MS (XL-MS) Homo sapiens
13 KRT8 3856
Cross-Linking-MS (XL-MS) Homo sapiens
14 CRK 1398
Affinity Capture-MS Homo sapiens
15 EPPK1 83481
Affinity Capture-MS Homo sapiens
16 EPS15 2060
Affinity Capture-MS Homo sapiens
17 DES 1674
Affinity Capture-MS Homo sapiens
18 IFFO1  
Affinity Capture-MS Homo sapiens
19 NHLRC2 374354
Affinity Capture-MS Homo sapiens
20 STK26 51765
Affinity Capture-MS Homo sapiens
21 FAM83H 286077
Affinity Capture-MS Homo sapiens
22 RNF208  
Affinity Capture-MS Homo sapiens
23 MKI67  
Affinity Capture-MS Homo sapiens
24 AP2M1 1173
Affinity Capture-MS Homo sapiens
25 SNAP47 116841
Affinity Capture-MS Homo sapiens
26 POC1A  
Affinity Capture-MS Homo sapiens
27 KRT15 3866
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 UBASH3B 84959
Affinity Capture-MS Homo sapiens
29 Nup107  
Affinity Capture-MS Mus musculus
30 ATP2B2 491
Affinity Capture-MS Homo sapiens
31 KRT75 9119
Cross-Linking-MS (XL-MS) Homo sapiens
32 IPO13 9670
Affinity Capture-MS Homo sapiens
33 Ttll7  
Affinity Capture-MS Mus musculus
34 ILK 3611
Affinity Capture-MS Homo sapiens
35 PCM1 5108
Affinity Capture-MS Homo sapiens
36 MYC  
Affinity Capture-MS Homo sapiens
37 APOA1 335
Cross-Linking-MS (XL-MS) Homo sapiens
38 FSCN1 6624
Affinity Capture-MS Homo sapiens
39 KRT19 3880
Cross-Linking-MS (XL-MS) Homo sapiens
40 KRT5 3852
Cross-Linking-MS (XL-MS) Homo sapiens
41 C9orf16  
Affinity Capture-MS Homo sapiens
42 KRT16 3868
Two-hybrid Homo sapiens
43 EIF3H 8667
Affinity Capture-MS Homo sapiens
44 UCHL5 51377
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which KRT73 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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