Gene description for E2F2
Gene name E2F transcription factor 2
Gene symbol E2F2
Other names/aliases E2F-2
Species Homo sapiens
 Database cross references - E2F2
ExoCarta ExoCarta_1870
Entrez Gene 1870
HGNC 3114
MIM 600426
UniProt Q14209  
 E2F2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for E2F2
Molecular Function
    transcription factor binding GO:0008134 IPI
    DNA binding GO:0003677 TAS
    protein binding GO:0005515 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    core promoter binding GO:0001047 IDA
Biological Process
    mitotic cell cycle GO:0000278 TAS
    lens fiber cell apoptotic process GO:1990086 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of cell cycle GO:0051726 IEA
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    transcription factor complex GO:0005667 IEA
 Experiment description of studies that identified E2F2 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for E2F2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 TFDP2  
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 SP1  
Invitro Homo sapiens
Invitro Homo sapiens
4 FHL2  
Two-hybrid Homo sapiens
5 BRD2  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
6 TFDP1  
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
7 SET8  
Two-hybrid Homo sapiens
8 SPIB  
Two-hybrid Homo sapiens
9 BCAR1 9564
Two-hybrid Homo sapiens
10 CDK3 1018
Invivo Homo sapiens
11 YY1 7528
Affinity Capture-MS Homo sapiens
12 RYBP  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
13 RNF144  
Two-hybrid Homo sapiens
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