Gene description for SRXN1
Gene name sulfiredoxin 1
Gene symbol SRXN1
Other names/aliases C20orf139
Npn3
SRX
SRX1
Species Homo sapiens
 Database cross references - SRXN1
ExoCarta ExoCarta_140809
Vesiclepedia VP_140809
Entrez Gene 140809
HGNC 16132
UniProt Q9BYN0  
 SRXN1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SRXN1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    oxidoreductase activity, acting on a sulfur group of donors GO:0016667 IDA
    sulfiredoxin activity GO:0032542 IBA
    sulfiredoxin activity GO:0032542 TAS
Biological Process
    response to oxidative stress GO:0006979 IDA
    cellular response to oxidative stress GO:0034599 IBA
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified SRXN1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SRXN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGBP1 3476
Co-fractionation Homo sapiens
2 STUB1 10273
Co-fractionation Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 TRIP6 7205
Co-fractionation Homo sapiens
5 TTC1 7265
Co-fractionation Homo sapiens
6 STAT6 6778
Co-fractionation Homo sapiens
7 ZRANB2 9406
Co-fractionation Homo sapiens
8 AHCYL1 10768
Co-fractionation Homo sapiens
9 USP34 9736
Co-fractionation Homo sapiens
10 CCDC102A 92922
Affinity Capture-MS Homo sapiens
11 UNK  
Co-fractionation Homo sapiens
12 TPM3P4  
Co-fractionation Homo sapiens
13 TPM2 7169
Co-fractionation Homo sapiens
14 ZPR1 8882
Co-fractionation Homo sapiens
15 GOT1 2805
Co-fractionation Homo sapiens
16 SSSCA1 10534
Co-fractionation Homo sapiens
17 USP9X 8239
Co-fractionation Homo sapiens
18 TLE3  
Co-fractionation Homo sapiens
19 PIR 8544
Co-fractionation Homo sapiens
20 CFL1 1072
Co-fractionation Homo sapiens
21 NUP35 129401
Proximity Label-MS Homo sapiens
22 PSMD7 5713
Co-fractionation Homo sapiens
23 RCN1 5954
Co-fractionation Homo sapiens
24 TUBB6 84617
Co-fractionation Homo sapiens
25 ATP6V1F 9296
Co-fractionation Homo sapiens
26 UBXN7 26043
Co-fractionation Homo sapiens
27 TPM1 7168
Co-fractionation Homo sapiens
28 SULT1A1 6817
Co-fractionation Homo sapiens
29 UBA2 10054
Co-fractionation Homo sapiens
30 PSMA5 5686
Co-fractionation Homo sapiens
31 PSMD2 5708
Co-fractionation Homo sapiens
32 KCNQ3  
Affinity Capture-MS Homo sapiens
33 TRIOBP 11078
Affinity Capture-MS Homo sapiens
34 DCAF10  
Affinity Capture-MS Homo sapiens
35 TTC9C 283237
Co-fractionation Homo sapiens
36 THADA 63892
Co-fractionation Homo sapiens
37 UBE2B 7320
Co-fractionation Homo sapiens
38 UCHL5 51377
Affinity Capture-MS Homo sapiens
39 PPM1G 5496
Co-fractionation Homo sapiens
40 TPM4 7171
Co-fractionation Homo sapiens
41 TOM1L2 146691
Co-fractionation Homo sapiens
42 TTLL12 23170
Co-fractionation Homo sapiens
43 TACC3  
Co-fractionation Homo sapiens
View the network image/svg+xml



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