Gene description for DYNLT1
Gene name dynein, light chain, Tctex-type 1
Gene symbol DYNLT1
Other names/aliases CW-1
TCTEL1
tctex-1
Species Homo sapiens
 Database cross references - DYNLT1
ExoCarta ExoCarta_6993
Entrez Gene 6993
HGNC 11697
MIM 601554
UniProt P63172  
 DYNLT1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for DYNLT1
Molecular Function
    motor activity GO:0003774 IEA
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
Biological Process
    mitotic nuclear division GO:0007067 IEA
    regulation of cytoskeleton organization GO:0051493 IEA
    establishment of mitotic spindle orientation GO:0000132 ISS
    viral entry into host cell GO:0046718 IEA
    negative regulation of neurogenesis GO:0050768 ISS
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 ISS
    neuron projection morphogenesis GO:0048812 IEA
    intracellular transport of viral protein in host cell GO:0019060 IMP
    microtubule-dependent intracellular transport of viral material towards nucleus GO:0075521 IEA
    metabolic process GO:0008152 IEA
    cell division GO:0051301 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    microtubule GO:0005874 IEA
    spindle GO:0005819 IEA
    host cell GO:0043657 IMP
    cytoplasmic dynein complex GO:0005868 ISS
 Experiment description of studies that identified DYNLT1 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DYNLT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNCI1  
Two-hybrid Homo sapiens
2 PVR 5817
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DYNLT1 is involved
No pathways found





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