Gene description for PEX14
Gene name peroxisomal biogenesis factor 14
Gene symbol PEX14
Other names/aliases NAPP2
PBD13A
Pex14p
dJ734G22.2
Species Homo sapiens
 Database cross references - PEX14
ExoCarta ExoCarta_5195
Vesiclepedia VP_5195
Entrez Gene 5195
HGNC 8856
MIM 601791
UniProt O75381  
 PEX14 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PEX14
Molecular Function
    transcription corepressor activity GO:0003714 IDA
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
    protein transmembrane transporter activity GO:0008320 IDA
    protein-macromolecule adaptor activity GO:0030674 IDA
    identical protein binding GO:0042802 IPI
    beta-tubulin binding GO:0048487 IPI
Biological Process
    peroxisome organization GO:0007031 IGI
    peroxisome organization GO:0007031 ISS
    protein import into peroxisome matrix GO:0016558 IMP
    protein import into peroxisome matrix, docking GO:0016560 IBA
    protein import into peroxisome matrix, docking GO:0016560 IDA
    protein import into peroxisome matrix, translocation GO:0016561 IDA
    negative regulation of protein binding GO:0032091 IDA
    microtubule anchoring GO:0034453 IDA
    cellular response to reactive oxygen species GO:0034614 IDA
    peroxisome transport along microtubule GO:0036250 IDA
    negative regulation of DNA-binding transcription factor activity GO:0043433 IDA
    protein import into peroxisome matrix, substrate release GO:0044721 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    protein-containing complex assembly GO:0065003 IDA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 NAS
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 HDA
    peroxisomal membrane GO:0005778 IBA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 ISS
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 ISS
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 ISS
    peroxisomal importomer complex GO:1990429 IBA
 Experiment description of studies that identified PEX14 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PEX14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATAD1 84896
Co-purification Homo sapiens
2 PEX13  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
3 HOMER3 9454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 C1orf198 84886
Proximity Label-MS Homo sapiens
5 ARHGEF2 9181
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
6 MTCH1 23787
Proximity Label-MS Homo sapiens
7 CCT3 7203
Co-purification Homo sapiens
8 VAPA 9218
Affinity Capture-MS Homo sapiens
9 PEX7  
Reconstituted Complex Homo sapiens
10 MKL1 57591
Proximity Label-MS Homo sapiens
11 LIMCH1 22998
Proximity Label-MS Homo sapiens
12 DYNC1I2 1781
Co-purification Homo sapiens
13 FOXJ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MED29  
Proximity Label-MS Homo sapiens
15 ACTC1 70
Proximity Label-MS Homo sapiens
16 FGF4  
Affinity Capture-MS Homo sapiens
17 TUBB8 347688
Co-purification Homo sapiens
18 CNP 1267
Co-purification Homo sapiens
19 CCT4 10575
Co-purification Homo sapiens
20 SYNE2 23224
Proximity Label-MS Homo sapiens
21 MYO5C 55930
Proximity Label-MS Homo sapiens
22 PTPN1 5770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
23 PHYH 5264
Affinity Capture-MS Homo sapiens
24 RUFY2  
Proximity Label-MS Homo sapiens
25 MARC2 54996
Proximity Label-MS Homo sapiens
26 TACC2 10579
Proximity Label-MS Homo sapiens
27 PEX1 5189
Proximity Label-MS Homo sapiens
28 RUFY1 80230
Proximity Label-MS Homo sapiens
29 LRPPRC 10128
Co-purification Homo sapiens
30 DYNC1H1 1778
Co-purification Homo sapiens
31 ELAVL3  
Co-fractionation Homo sapiens
32 PCNT  
Proximity Label-MS Homo sapiens
33 C8orf59  
Affinity Capture-MS Homo sapiens
34 IFT74 80173
Proximity Label-MS Homo sapiens
35 NAV1 89796
Proximity Label-MS Homo sapiens
36 RAB3B 5865
Proximity Label-MS Homo sapiens
37 IMPDH2 3615
Co-purification Homo sapiens
38 IQGAP1 8826
Co-purification Homo sapiens
39 ERC1 23085
Proximity Label-MS Homo sapiens
40 ABCD3 5825
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
41 PLEKHG1  
Proximity Label-MS Homo sapiens
42 MARCH5  
Proximity Label-MS Homo sapiens
43 VPS13D 55187
Proximity Label-MS Homo sapiens
44 PNPLA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CROCC 9696
Affinity Capture-MS Homo sapiens
46 EXD2  
Proximity Label-MS Homo sapiens
47 PRKAR2B 5577
Proximity Label-MS Homo sapiens
48 RGPD6  
Proximity Label-MS Homo sapiens
49 PEX26  
FRET Homo sapiens
50 TUBB6 84617
Co-purification Homo sapiens
51 MAVS 57506
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
52 HSD17B4 3295
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
53 KNSTRN  
Proximity Label-MS Homo sapiens
54 CEP131 22994
Proximity Label-MS Homo sapiens
55 HK1 3098
Proximity Label-MS Homo sapiens
56 GNPAT 8443
Co-purification Homo sapiens
57 TEX9  
Proximity Label-MS Homo sapiens
58 KIF14 9928
Affinity Capture-MS Homo sapiens
59 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ARFIP1 27236
Proximity Label-MS Homo sapiens
61 CCT2 10576
Co-purification Homo sapiens
62 PXMP2  
Proximity Label-MS Homo sapiens
63 CENPK  
Two-hybrid Homo sapiens
64 SPAG5 10615
Proximity Label-MS Homo sapiens
65 TCP1 6950
Co-purification Homo sapiens
66 SCFD1 23256
Proximity Label-MS Homo sapiens
67 CENPH  
Proximity Label-MS Homo sapiens
68 NUP88 4927
Proximity Label-MS Homo sapiens
69 PEX12  
Co-purification Homo sapiens
70 LPP 4026
Proximity Label-MS Homo sapiens
71 PIBF1  
Proximity Label-MS Homo sapiens
72 CEP55 55165
Proximity Label-MS Homo sapiens
73 RABEP1 9135
Proximity Label-MS Homo sapiens
74 CLNS1A 1207
Affinity Capture-MS Homo sapiens
75 TUBA1A 7846
Co-purification Homo sapiens
76 CCT5 22948
Co-purification Homo sapiens
77 VPS52 6293
Proximity Label-MS Homo sapiens
78 ASNA1 439
Two-hybrid Homo sapiens
79 GCC2 9648
Proximity Label-MS Homo sapiens
80 TUBB2B 347733
Co-purification Homo sapiens
81 CNOT1 23019
Co-purification Homo sapiens
82 CAMSAP3  
Proximity Label-MS Homo sapiens
83 CCL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 OGT 8473
Reconstituted Complex Homo sapiens
85 NUP62 23636
Proximity Label-MS Homo sapiens
86 DCTN1 1639
Co-purification Homo sapiens
87 PEX14 5195
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
88 KIF11 3832
Co-purification Homo sapiens
89 NME3 4832
Affinity Capture-MS Homo sapiens
90 COG3 83548
Proximity Label-MS Homo sapiens
91 Arhgap18  
Affinity Capture-MS Mus musculus
92 CCDC22 28952
Proximity Label-MS Homo sapiens
93 IKZF5 64376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 PRKAR2A 5576
Proximity Label-MS Homo sapiens
95 ENY2 56943
Affinity Capture-MS Homo sapiens
96 DNM2 1785
Co-purification Homo sapiens
97 SPC24 147841
Proximity Label-MS Homo sapiens
98 AGPS 8540
Proximity Label-MS Homo sapiens
Co-purification Homo sapiens
99 RHOT2 89941
Proximity Label-MS Homo sapiens
100 DNM1L 10059
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
101 KIF20B  
Proximity Label-MS Homo sapiens
102 IQGAP2 10788
Co-purification Homo sapiens
103 RMDN3 55177
Proximity Label-MS Homo sapiens
104 ACBD3 64746
Proximity Label-MS Homo sapiens
105 SMARCC2 6601
Two-hybrid Homo sapiens
106 PEX6  
Proximity Label-MS Homo sapiens
107 PPP2R3A  
Proximity Label-MS Homo sapiens
108 EIF3G 8666
Affinity Capture-MS Homo sapiens
109 KIF1B 23095
Proximity Label-MS Homo sapiens
110 TUBB 203068
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
111 STUB1 10273
Proximity Label-MS Homo sapiens
112 CEP63  
Proximity Label-MS Homo sapiens
113 ATF6  
Proximity Label-MS Homo sapiens
114 ZHX1  
Two-hybrid Homo sapiens
115 TNKS 8658
Proximity Label-MS Homo sapiens
116 OCRL 4952
Proximity Label-MS Homo sapiens
117 NELFCD 51497
Proximity Label-MS Homo sapiens
118 CCT6A 908
Co-purification Homo sapiens
119 LMO7 4008
Proximity Label-MS Homo sapiens
120 TUBB4B 10383
Co-purification Homo sapiens
121 C11orf49  
Proximity Label-MS Homo sapiens
122 IFT57 55081
Proximity Label-MS Homo sapiens
123 LMTK2 22853
Proximity Label-MS Homo sapiens
124 NR3C1 2908
Proximity Label-MS Homo sapiens
125 PEX10  
Co-purification Homo sapiens
126 MTNR1A  
Two-hybrid Homo sapiens
127 FKBP8 23770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
128 ATRIP  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
129 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
130 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 CDR2  
Proximity Label-MS Homo sapiens
132 TUBA4A 7277
Co-purification Homo sapiens
133 EXOC4 60412
Proximity Label-MS Homo sapiens
134 BIRC6 57448
Proximity Label-MS Homo sapiens
135 ALDH3A2 224
Proximity Label-MS Homo sapiens
136 CNTROB  
Proximity Label-MS Homo sapiens
137 CEP170B  
Proximity Label-MS Homo sapiens
138 TACC1 6867
Proximity Label-MS Homo sapiens
139 TP63  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 SIRT6  
Affinity Capture-MS Homo sapiens
141 PEX5 5830
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
142 KIAA1671  
Proximity Label-MS Homo sapiens
143 PEX2  
Co-purification Homo sapiens
144 P4HA3 283208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 N4BP2  
Proximity Label-MS Homo sapiens
146 MIER2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 PNPLA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 PEX3 8504
Proximity Label-MS Homo sapiens
Co-purification Homo sapiens
149 CCL4L1  
Affinity Capture-MS Homo sapiens
150 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
151 UBXN4 23190
Proximity Label-MS Homo sapiens
152 ACBD5 91452
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
153 MPHOSPH9  
Proximity Label-MS Homo sapiens
154 KIF15 56992
Proximity Label-MS Homo sapiens
155 SMCR8 140775
Proximity Label-MS Homo sapiens
156 TUBB2A 7280
Co-purification Homo sapiens
157 SUGT1 10910
Proximity Label-MS Homo sapiens
158 NUMBL 9253
Proximity Label-MS Homo sapiens
159 SPICE1  
Proximity Label-MS Homo sapiens
160 MAP2K2 5605
Co-purification Homo sapiens
161 PRKCSH 5589
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 PEX16 9409
Co-purification Homo sapiens
163 CCT8 10694
Co-purification Homo sapiens
164 TTC1 7265
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
165 TDRKH  
Proximity Label-MS Homo sapiens
166 ITSN1 6453
Proximity Label-MS Homo sapiens
167 TRAK1 22906
Affinity Capture-MS Homo sapiens
168 SCYL2 55681
Proximity Label-MS Homo sapiens
169 SYAP1 94056
Proximity Label-MS Homo sapiens
170 TUBG2  
Co-purification Homo sapiens
171 INPPL1 3636
Proximity Label-MS Homo sapiens
172 PEX19 5824
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Proximity Label-MS Homo sapiens
173 SDCCAG3  
Proximity Label-MS Homo sapiens
174 POLR3H  
Affinity Capture-MS Homo sapiens
175 UBA52 7311
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
176 MED8  
Two-hybrid Homo sapiens
177 TUBB3 10381
Co-purification Homo sapiens
178 ARHGAP18 93663
Proximity Label-MS Homo sapiens
179 SNX2 6643
Proximity Label-MS Homo sapiens
180 STK38L 23012
Affinity Capture-MS Homo sapiens
181 MAGEA9  
Affinity Capture-MS Homo sapiens
182 TUBB4A 10382
Co-purification Homo sapiens
183 CCT7 10574
Co-purification Homo sapiens
184 KIAA0430  
Two-hybrid Homo sapiens
185 FAR1 84188
Co-purification Homo sapiens
186 PDZD8 118987
Proximity Label-MS Homo sapiens
187 AFG3L2 10939
Proximity Label-MS Homo sapiens
188 COG4 25839
Proximity Label-MS Homo sapiens
189 E2F4  
Affinity Capture-MS Homo sapiens
190 STXBP4 252983
Proximity Label-MS Homo sapiens
191 GAK 2580
Proximity Label-MS Homo sapiens
192 ATP5B 506
Proximity Label-MS Homo sapiens
193 DHRS4 10901
Co-purification Homo sapiens
194 LIMD1 8994
Proximity Label-MS Homo sapiens
195 RPL28 6158
Affinity Capture-MS Homo sapiens
196 NEU2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 CROCCP2  
Affinity Capture-MS Homo sapiens
198 SCP2 6342
Proximity Label-MS Homo sapiens
199 COPS4 51138
Two-hybrid Homo sapiens
200 DYNC2H1 79659
Co-purification Homo sapiens
201 CACYBP 27101
Proximity Label-MS Homo sapiens
202 UNC13B 10497
Proximity Label-MS Homo sapiens
203 CC2D1A 54862
Proximity Label-MS Homo sapiens
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