Gene description for CLUH
Gene name clustered mitochondria (cluA/CLU1) homolog
Gene symbol CLUH
Other names/aliases CLU1
KIAA0664
Species Homo sapiens
 Database cross references - CLUH
ExoCarta ExoCarta_23277
Entrez Gene 23277
HGNC 29094
MIM 616184
UniProt O75153  
 CLUH identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for CLUH
Molecular Function
    mRNA binding GO:0003729 IDA
Biological Process
    intracellular distribution of mitochondria GO:0048312 IMP
    mitochondrion organization GO:0007005 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified CLUH in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLUH
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLUH is involved
No pathways found





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