Gene description for COX7A2
Gene name cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
Gene symbol COX7A2
Other names/aliases COX7AL
COX7AL1
COXVIIAL
COXVIIa-L
VIIAL
Species Homo sapiens
 Database cross references - COX7A2
ExoCarta ExoCarta_1347
Vesiclepedia VP_1347
Entrez Gene 1347
HGNC 2288
MIM 123996
UniProt P14406  
 COX7A2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX7A2
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 IEA
Biological Process
    regulation of oxidative phosphorylation GO:0002082 IBA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 NAS
    cellular respiration GO:0045333 NAS
    mitochondrial respirasome assembly GO:0097250 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial membrane GO:0031966 IDA
    respiratory chain complex IV GO:0045277 IEA
    respiratory chain complex GO:0098803 IBA
 Experiment description of studies that identified COX7A2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX7A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
2 NDUFS1 4719
Co-fractionation Homo sapiens
3 MTX1 4580
Co-fractionation Homo sapiens
4 FBXL19  
Affinity Capture-MS Homo sapiens
5 CSTA 1475
Co-fractionation Homo sapiens
6 NDUFA4 4697
Affinity Capture-MS Homo sapiens
7 FFAR1  
Affinity Capture-MS Homo sapiens
8 NDUFS2 4720
Co-fractionation Homo sapiens
9 TOMM22 56993
Co-fractionation Homo sapiens
10 GOLGA7 51125
Affinity Capture-MS Homo sapiens
11 NDUFB9 4715
Co-fractionation Homo sapiens
12 MGST1 4257
Co-fractionation Homo sapiens
13 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
14 OGDH 4967
Co-fractionation Homo sapiens
15 KIF23 9493
Affinity Capture-MS Homo sapiens
16 COQ9  
Affinity Capture-MS Homo sapiens
17 COX7A2L 9167
Co-fractionation Homo sapiens
18 PTPMT1 114971
Affinity Capture-MS Homo sapiens
19 COA3 28958
Co-fractionation Homo sapiens
20 CHCHD10  
Affinity Capture-MS Homo sapiens
21 MTMR2 8898
Affinity Capture-MS Homo sapiens
22 PSMC2 5701
Affinity Capture-MS Homo sapiens
23 HADHA 3030
Co-fractionation Homo sapiens
24 COX7B2  
Affinity Capture-MS Homo sapiens
25 C20orf24  
Co-fractionation Homo sapiens
26 NDUFV1 4723
Co-fractionation Homo sapiens
27 PHB 5245
Co-fractionation Homo sapiens
28 UQCRQ 27089
Co-fractionation Homo sapiens
29 NDUFS5 4725
Co-fractionation Homo sapiens
30 KLF16  
Affinity Capture-MS Homo sapiens
31 APOO 79135
Proximity Label-MS Homo sapiens
32 EGLN3  
Affinity Capture-MS Homo sapiens
33 DNLZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 COX15 1355
Affinity Capture-MS Homo sapiens
35 ANTXR1 84168
Affinity Capture-MS Homo sapiens
36 SURF1  
Proximity Label-MS Homo sapiens
37 HSP90B1 7184
Co-fractionation Homo sapiens
38 NDUFA8 4702
Co-fractionation Homo sapiens
39 ACACA 31
Affinity Capture-MS Homo sapiens
40 USMG5 84833
Co-fractionation Homo sapiens
41 PMAIP1  
Affinity Capture-MS Homo sapiens
42 MEOX2  
Two-hybrid Homo sapiens
43 CYC1 1537
Co-fractionation Homo sapiens
44 ACTB 60
Co-fractionation Homo sapiens
45 UPK1A 11045
Affinity Capture-MS Homo sapiens
46 DNAJC30  
Proximity Label-MS Homo sapiens
47 NDUFAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 MYL12A 10627
Co-fractionation Homo sapiens
49 VDAC2 7417
Co-fractionation Homo sapiens
50 SEC61B 10952
Co-fractionation Homo sapiens
51 ATP5B 506
Co-fractionation Homo sapiens
52 COX4I1 1327
Affinity Capture-MS Homo sapiens
53 CISD3 284106
Affinity Capture-MS Homo sapiens
54 FOXH1  
Affinity Capture-MS Homo sapiens
55 C15orf48  
Affinity Capture-MS Homo sapiens
56 HADHB 3032
Co-fractionation Homo sapiens
57 SLC25A12 8604
Proximity Label-MS Homo sapiens
58 NDUFA9 4704
Co-fractionation Homo sapiens
59 UQCRC2 7385
Co-fractionation Homo sapiens
60 MEX3A  
Affinity Capture-RNA Homo sapiens
61 COX6A1  
Affinity Capture-MS Homo sapiens
62 TOP3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 COX6B1 1340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 Wash  
Affinity Capture-MS Mus musculus
65 CORO1C 23603
Co-fractionation Homo sapiens
66 OCIAD1 54940
Affinity Capture-MS Homo sapiens
67 PHB2 11331
Co-fractionation Homo sapiens
68 SOAT1 6646
Affinity Capture-MS Homo sapiens
69 NDUFB3 4709
Cross-Linking-MS (XL-MS) Homo sapiens
70 ATP6V1A 523
Co-fractionation Homo sapiens
71 VDAC1 7416
Affinity Capture-MS Homo sapiens
72 COX2 4513
Co-fractionation Homo sapiens
73 SCCPDH 51097
Co-fractionation Homo sapiens
74 IMMT 10989
Co-fractionation Homo sapiens
75 PSMB10 5699
Affinity Capture-MS Homo sapiens
76 BCKDHA 593
Co-fractionation Homo sapiens
77 PDHA1 5160
Co-fractionation Homo sapiens
78 NDUFS7 374291
Co-fractionation Homo sapiens
79 PDHB 5162
Co-fractionation Homo sapiens
80 AGPAT3 56894
Affinity Capture-MS Homo sapiens
81 UNK  
Affinity Capture-RNA Homo sapiens
82 NDUFS8 4728
Co-fractionation Homo sapiens
83 CNDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 RAB7A 7879
Co-fractionation Homo sapiens
85 TCF3  
Affinity Capture-MS Homo sapiens
86 ATP5C1 509
Co-fractionation Homo sapiens
87 PAF1 54623
Affinity Capture-MS Homo sapiens
88 TOMM5  
Co-fractionation Homo sapiens
View the network image/svg+xml



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