Gene description for TDG
Gene name	thymine-DNA glycosylase
Gene symbol	TDG
Other names/aliases	hTDG
Species	Homo sapiens
Database cross references - TDG
ExoCarta	ExoCarta_6996
Entrez Gene	6996
HGNC	11700
MIM	601423
UniProt	Q13569
TDG identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TDG

Molecular Function     damaged DNA binding GO:0003684 TAS     protein homodimerization activity GO:0042803 IDA     protein domain specific binding GO:0019904 IEA     SUMO binding GO:0032183 IEA     structure-specific DNA binding GO:0043566 ISS     pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 IDA     DNA N-glycosylase activity GO:0019104 IDA     mismatched DNA binding GO:0030983 IDA     RNA polymerase II transcription cofactor activity GO:0001104 IEA     protein binding GO:0005515 IPI     double-stranded DNA binding GO:0003690 IDA     transcription factor binding GO:0008134 IEA     protein kinase C binding GO:0005080 IEA Biological Process     transcription from RNA polymerase II promoter GO:0006366 IEA     negative regulation of chromatin binding GO:0035562 IEA     regulation of gene expression, epigenetic GO:0040029 TAS     negative regulation of protein binding GO:0032091 IEA     DNA repair GO:0006281 TAS     embryo development GO:0009790 ISS     cellular protein metabolic process GO:0044267 TAS     DNA demethylation GO:0080111 ISS     mismatch repair GO:0006298 IDA     oxidative DNA demethylation GO:0035511 TAS     chromatin modification GO:0016568 IEA     base-excision repair GO:0006284 TAS     depyrimidination GO:0045008 TAS     base-excision repair, AP site formation GO:0006285 TAS     gene expression GO:0010467 TAS     protein sumoylation GO:0016925 TAS     post-translational protein modification GO:0043687 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA Subcellular Localization     nucleoplasm GO:0005654 TAS     plasma membrane GO:0005886 IDA     PML body GO:0016605 IEA     nucleus GO:0005634 IDA