Gene description for TDG
Gene name	thymine-DNA glycosylase
Gene symbol	TDG
Other names/aliases	hTDG
Species	Homo sapiens
Database cross references - TDG
ExoCarta	ExoCarta_6996
Vesiclepedia	VP_6996
Entrez Gene	6996
HGNC	11700
MIM	601423
UniProt	Q13569
TDG identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TDG

Molecular Function     magnesium ion binding GO:0000287 IDA     nucleic acid binding GO:0003676 EXP     DNA binding GO:0003677 ISS     damaged DNA binding GO:0003684 TAS     double-stranded DNA binding GO:0003690 IDA     transcription coregulator activity GO:0003712 IEA     uracil DNA N-glycosylase activity GO:0004844 IBA     uracil DNA N-glycosylase activity GO:0004844 IDA     protein kinase C binding GO:0005080 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 IBA     pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 IDA     pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 IMP     DNA N-glycosylase activity GO:0019104 IDA     DNA N-glycosylase activity GO:0019104 IMP     DNA N-glycosylase activity GO:0019104 TAS     protein domain specific binding GO:0019904 IEA     mismatched DNA binding GO:0030983 IDA     sodium ion binding GO:0031402 IDA     chloride ion binding GO:0031404 IDA     SUMO binding GO:0032183 IPI     G/U mismatch-specific uracil-DNA glycosylase activity GO:0043739 IMP     DNA-binding transcription factor binding GO:0140297 IEA     G/T mismatch-specific thymine-DNA glycosylase activity GO:0141016 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     base-excision repair GO:0006284 IDA     base-excision repair, AP site formation GO:0006285 IBA     epigenetic regulation of gene expression GO:0040029 ISS     depyrimidination GO:0045008 TAS     regulation of embryonic development GO:0045995 IEA     chromosomal 5-methylcytosine DNA demethylation, oxidation pathway GO:0141167 TAS Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     plasma membrane GO:0005886 IDA     PML body GO:0016605 IEA