Gene description for CAMK2D
Gene name calcium/calmodulin-dependent protein kinase II delta
Gene symbol CAMK2D
Other names/aliases CAMKD
Species Homo sapiens
 Database cross references - CAMK2D
ExoCarta ExoCarta_817
Vesiclepedia VP_817
Entrez Gene 817
HGNC 1462
MIM 607708
UniProt Q13557  
 CAMK2D identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Thymus 23844026    
 Gene ontology annotations for CAMK2D
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IDA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 IPI
    ATP binding GO:0005524 IEA
    sodium channel inhibitor activity GO:0019871 IDA
    titin binding GO:0031432 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    transmembrane transporter binding GO:0044325 IPI
    transmembrane transporter binding GO:0044325 ISS
    protein serine kinase activity GO:0106310 IEA
Biological Process
    regulation of cell growth GO:0001558 NAS
    regulation of the force of heart contraction GO:0002026 TAS
    regulation of membrane depolarization GO:0003254 IDA
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    protein phosphorylation GO:0006468 IDA
    regulation of heart contraction GO:0008016 TAS
    positive regulation of cardiac muscle hypertrophy GO:0010613 IMP
    regulation of cell communication by electrical coupling GO:0010649 ISS
    positive regulation of cardiac muscle cell apoptotic process GO:0010666 ISS
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 ISS
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 IC
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 TAS
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    endoplasmic reticulum calcium ion homeostasis GO:0032469 ISS
    protein autophosphorylation GO:0046777 IDA
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    relaxation of cardiac muscle GO:0055119 ISS
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 TAS
    regulation of cellular localization GO:0060341 IMP
    cellular response to calcium ion GO:0071277 TAS
    cardiac muscle cell contraction GO:0086003 ISS
    regulation of heart rate by cardiac conduction GO:0086091 IC
    regulation of cardiac muscle cell action potential GO:0098901 ISS
    regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 IC
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 IC
    regulation of relaxation of cardiac muscle GO:1901897 IDA
    negative regulation of sodium ion transmembrane transport GO:1902306 IDA
    regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 ISS
    regulation of protein localization to plasma membrane GO:1903076 IBA
    negative regulation of sodium ion transmembrane transporter activity GO:2000650 IDA
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    calcium- and calmodulin-dependent protein kinase complex GO:0005954 IDA
    postsynaptic density GO:0014069 IBA
    membrane GO:0016020 HDA
    endocytic vesicle membrane GO:0030666 TAS
    sarcoplasmic reticulum membrane GO:0033017 IEA
    sarcolemma GO:0042383 IEA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified CAMK2D in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
16
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CAMK2D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 HDAC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
3 MAGEA3  
Affinity Capture-MS Homo sapiens
4 MOAP1  
Two-hybrid Homo sapiens
5 EBNA-LP  
Affinity Capture-MS
6 FAM163B  
Affinity Capture-MS Homo sapiens
7 POM121  
Affinity Capture-MS Homo sapiens
8 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KANSL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ASXL1  
Affinity Capture-MS Homo sapiens
11 MOK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 DTL  
Affinity Capture-MS Homo sapiens
13 RPS18 6222
Affinity Capture-Western Homo sapiens
14 WDR76  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 C21orf2  
Affinity Capture-MS Homo sapiens
16 ZNF843  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DYRK1A 1859
Affinity Capture-MS Homo sapiens
18 ZRANB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CALM3 808
Affinity Capture-MS Homo sapiens
20 GUSBP5  
Affinity Capture-MS Homo sapiens
21 FTSJ2 29960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TIAM1  
Affinity Capture-MS Homo sapiens
23 PUSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CAMK2B 816
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TPRN 286262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ATG16L1 55054
Affinity Capture-MS Homo sapiens
27 POLR2C 5432
Proximity Label-MS Homo sapiens
28 SENP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 BOD1L1 259282
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 POLR1E  
Proximity Label-MS Homo sapiens
31 SETD1A 9739
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RBM42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NPAS1  
Affinity Capture-MS Homo sapiens
34 WASF3 10810
Two-hybrid Homo sapiens
35 DPH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RBPJ 3516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PRNP 5621
Affinity Capture-MS Homo sapiens
38 CALM2 805
Affinity Capture-MS Homo sapiens
39 ALAS1  
Affinity Capture-MS Homo sapiens
40 CAMK2A 815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 BANP  
Two-hybrid Homo sapiens
42 HAUS2  
Affinity Capture-MS Homo sapiens
43 DNAL4  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
44 DBNL 28988
Affinity Capture-Western Homo sapiens
45 SPATA24  
Two-hybrid Homo sapiens
46 ARL2BP 23568
Two-hybrid Homo sapiens
47 CDKN1A  
Affinity Capture-MS Homo sapiens
48 PARK2  
Affinity Capture-MS Homo sapiens
49 NDUFA8 4702
Affinity Capture-MS Homo sapiens
50 UBE2I 7329
Two-hybrid Homo sapiens
51 TRMT61A 115708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 EPHA10  
Two-hybrid Homo sapiens
53 TNPO2 30000
Two-hybrid Homo sapiens
54 TSR3  
Affinity Capture-MS Homo sapiens
55 OGT 8473
Affinity Capture-MS Homo sapiens
56 AIM2  
Affinity Capture-MS Homo sapiens
57 IFI16 3428
Affinity Capture-MS Homo sapiens
58 ARRDC3 57561
Affinity Capture-MS Homo sapiens
59 MRPL11 65003
Two-hybrid Homo sapiens
60 CEP76  
Affinity Capture-MS Homo sapiens
61 DNM1L 10059
Cross-Linking-MS (XL-MS) Homo sapiens
62 CYLD  
Affinity Capture-MS Homo sapiens
63 SRPK1 6732
Biochemical Activity Homo sapiens
64 TIRAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 DACT2  
Affinity Capture-MS Homo sapiens
66 FNDC3B 64778
Two-hybrid Homo sapiens
67 ZBTB2 57621
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 MAP7 9053
Affinity Capture-MS Homo sapiens
69 NR3C1 2908
Affinity Capture-MS Homo sapiens
70 MAGEB4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 HCFC1 3054
Affinity Capture-MS Homo sapiens
72 ELP3 55140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CUL3 8452
Affinity Capture-MS Homo sapiens
74 UNG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 LIN54  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PTK2 5747
Proximity Label-MS Homo sapiens
77 IQCF1  
Affinity Capture-MS Homo sapiens
78 ECHS1 1892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 SSH3 54961
Affinity Capture-MS Homo sapiens
80 ARHGAP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 ARHGAP29 9411
Affinity Capture-MS Homo sapiens
82 MTG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 MYC  
Dosage Lethality Homo sapiens
Affinity Capture-MS Homo sapiens
84 RPA3 6119
Proximity Label-MS Homo sapiens
85 FXR2 9513
Two-hybrid Homo sapiens
86 HNMT 3176
Two-hybrid Homo sapiens
87 BAP1 8314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 DIDO1  
Affinity Capture-MS Homo sapiens
89 SCRN2 90507
Affinity Capture-MS Homo sapiens
90 FKBP1B  
Two-hybrid Homo sapiens
91 ARMCX5  
Affinity Capture-MS Homo sapiens
92 CAMK2G 818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
93 ELP2 55250
Affinity Capture-MS Homo sapiens
94 IFNGR2  
Two-hybrid Homo sapiens
95 TTC5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
96 IKBKAP 8518
Affinity Capture-MS Homo sapiens
97 ARRB2 409
Affinity Capture-MS Homo sapiens
98 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
99 EPB41L4B 54566
Affinity Capture-MS Homo sapiens
100 SHISA6  
Affinity Capture-MS Homo sapiens
101 THUMPD3 25917
Affinity Capture-MS Homo sapiens
102 FAM171B  
Two-hybrid Homo sapiens
103 MCM5 4174
Affinity Capture-MS Homo sapiens
104 WNT4  
Affinity Capture-MS Homo sapiens
105 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 RPS4X 6191
Two-hybrid Homo sapiens
107 MAP10  
Affinity Capture-MS Homo sapiens
108 RCHY1  
Affinity Capture-Western Homo sapiens
109 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
110 MAGEA9  
Affinity Capture-MS Homo sapiens
111 NEK1  
Affinity Capture-MS Homo sapiens
112 PGAM2 5224
Affinity Capture-MS Homo sapiens
113 C6orf141  
Affinity Capture-MS Homo sapiens
114 TSHR 7253
Affinity Capture-MS Homo sapiens
115 C12orf74  
Affinity Capture-MS Homo sapiens
116 NEDD1 121441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 CXXC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 BAG5 9529
Affinity Capture-MS Homo sapiens
119 CAMK2D 817
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
120 C9orf72  
Affinity Capture-MS Homo sapiens
121 CCT8L2  
Affinity Capture-MS Homo sapiens
122 CUL4A 8451
Affinity Capture-MS Homo sapiens
123 DNAH14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAMK2D is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of NMDA receptors and postsynaptic events TAS Reactome
Assembly and cell surface presentation of NMDA receptors IEA Reactome
Ca-dependent events IEA Reactome
Calmodulin induced events IEA Reactome
CaM pathway IEA Reactome
CaMK IV-mediated phosphorylation of CREB IEA Reactome
Cardiac conduction TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
DAG and IP3 signaling IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
G alpha (i) signalling events IEA Reactome
G-protein mediated events IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity TAS Reactome
GPCR downstream signalling IEA Reactome
HSF1-dependent transactivation TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Ion channel transport TAS Reactome
Ion homeostasis TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Long-term potentiation IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Muscle contraction TAS Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission IEA Reactome
Neuronal System IEA Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Oncogenic MAPK signaling TAS Reactome
Opioid Signalling IEA Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Phase 0 - rapid depolarisation TAS Reactome
PLC beta mediated events IEA Reactome
Post NMDA receptor activation events IEA Reactome
RAF activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Ras activation upon Ca2+ influx through NMDA receptor IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Trafficking of AMPA receptors TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Transmission across Chemical Synapses TAS Reactome
Transport of small molecules TAS Reactome
Unblocking of NMDA receptors, glutamate binding and activation TAS Reactome
Unblocking of NMDA receptors, glutamate binding and activation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here