Gene description for AHCYL2
Gene name adenosylhomocysteinase-like 2
Gene symbol AHCYL2
Other names/aliases ADOHCYASE3
IRBIT2
Species Homo sapiens
 Database cross references - AHCYL2
ExoCarta ExoCarta_23382
Vesiclepedia VP_23382
Entrez Gene 23382
HGNC 22204
UniProt Q96HN2  
 AHCYL2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for AHCYL2
Molecular Function
    adenosylhomocysteinase activity GO:0004013 IBA
    protein binding GO:0005515 IPI
Biological Process
    one-carbon metabolic process GO:0006730 IEA
    S-adenosylmethionine cycle GO:0033353 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IBA
    neuron projection GO:0043005 IEA
 Experiment description of studies that identified AHCYL2 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AHCYL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDC14B 8555
Affinity Capture-MS Homo sapiens
2 CAMKV 79012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 PITX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LNP1  
Affinity Capture-MS Homo sapiens
6 MARCKS 4082
Proximity Label-MS Homo sapiens
7 EN1  
Affinity Capture-MS Homo sapiens
8 VSX2 338917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 DHX8 1659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DACT1 51339
Affinity Capture-MS Homo sapiens
11 FAM13C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 C4orf26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PLEKHA2 59339
Affinity Capture-MS Homo sapiens
14 PTPN1 5770
Proximity Label-MS Homo sapiens
15 SRSF2 6427
Affinity Capture-MS Homo sapiens
16 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HOXB6 3216
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HOXB9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 WDR48 57599
Affinity Capture-MS Homo sapiens
20 HOXA5  
Affinity Capture-MS Homo sapiens
21 NFKBIL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CPSF4  
Affinity Capture-MS Homo sapiens
23 ANP32B 10541
Co-fractionation Homo sapiens
24 DUSP11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ZNF460  
Affinity Capture-MS Homo sapiens
26 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SOST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MBD3L2  
Affinity Capture-MS Homo sapiens
29 KNDC1  
Affinity Capture-MS Homo sapiens
30 FOXD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RAB35 11021
Proximity Label-MS Homo sapiens
32 BTRC 8945
Affinity Capture-MS Homo sapiens
33 MAPK4  
Affinity Capture-MS Homo sapiens
34 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 AHCYL1 10768
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PRNP 5621
Affinity Capture-MS Homo sapiens
37 COBL  
Affinity Capture-MS Homo sapiens
38 BANP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 SYT2  
Affinity Capture-MS Homo sapiens
40 ZIC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CLK4  
Affinity Capture-MS Homo sapiens
42 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ZNF444  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PSMD4 5710
Co-fractionation Homo sapiens
45 FOXK1 221937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ABCF2 10061
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PTPN21 11099
Affinity Capture-MS Homo sapiens
49 FOXK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 JOSD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ACTB 60
Proximity Label-MS Homo sapiens
52 CSNK1E 1454
Affinity Capture-MS Homo sapiens
53 TGIF2LY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CEP72  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RASL10B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SEC61B 10952
Proximity Label-MS Homo sapiens
57 KIF18B 146909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 DKK2  
Affinity Capture-MS Homo sapiens
59 CT45A5  
Affinity Capture-MS Homo sapiens
60 ZBTB44  
Affinity Capture-MS Homo sapiens
61 FOXF2  
Affinity Capture-MS Homo sapiens
62 NUAK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 AHCY 191
Affinity Capture-MS Homo sapiens
64 CLK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 XPO1 7514
Affinity Capture-MS Homo sapiens
66 FGF12  
Affinity Capture-MS Homo sapiens
67 WDR33 55339
Affinity Capture-MS Homo sapiens
68 DOK4 55715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 SYT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 BAP1 8314
Affinity Capture-MS Homo sapiens
71 ANKRD36B  
Affinity Capture-MS Homo sapiens
72 ANP32E 81611
Co-fractionation Homo sapiens
73 IKZF4  
Affinity Capture-MS Homo sapiens
74 JUN 3725
Affinity Capture-MS Homo sapiens
75 FGF11  
Affinity Capture-MS Homo sapiens
76 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 C1orf174  
Affinity Capture-MS Homo sapiens
78 FAM13A 10144
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 MSL1 339287
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CREB3L3  
Affinity Capture-MS Homo sapiens
81 TFPI2 7980
Affinity Capture-MS Homo sapiens
82 UNKL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
84 RHOB 388
Proximity Label-MS Homo sapiens
85 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 ZNF263  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 CAB39 51719
Affinity Capture-MS Homo sapiens
89 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 GRN 2896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 CLK1  
Affinity Capture-MS Homo sapiens
93 PDCD2L 84306
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ZEB1  
Affinity Capture-MS Homo sapiens
95 EZR 7430
Proximity Label-MS Homo sapiens
96 PLCD3 113026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 PITX1  
Affinity Capture-MS Homo sapiens
98 PLEKHJ1  
Affinity Capture-MS Homo sapiens
99 C11orf52 91894
Proximity Label-MS Homo sapiens
100 RBM23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 HOXC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 HEXIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SNX20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 EEF1D 1936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ARSI 340075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ZBTB3  
Affinity Capture-MS Homo sapiens
107 RPS8 6202
Co-fractionation Homo sapiens
108 ZNF641  
Affinity Capture-MS Homo sapiens
109 KRAS 3845
Proximity Label-MS Homo sapiens
110 CAPN10  
Affinity Capture-MS Homo sapiens
111 CAV1 857
Proximity Label-MS Homo sapiens
112 RPL17 6139
Co-fractionation Homo sapiens
113 GREM2 64388
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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