Gene description for NQO2
Gene name NAD(P)H dehydrogenase, quinone 2
Gene symbol NQO2
Other names/aliases DHQV
DIA6
NMOR2
QR2
Species Homo sapiens
 Database cross references - NQO2
ExoCarta ExoCarta_4835
Vesiclepedia VP_4835
Entrez Gene 4835
HGNC 7856
MIM 160998
UniProt P16083  
 NQO2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for NQO2
Molecular Function
    dihydronicotinamide riboside quinone reductase activity GO:0001512 IDA
    NAD(P)H dehydrogenase (quinone) activity GO:0003955 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    electron transfer activity GO:0009055 IDA
    oxidoreductase activity GO:0016491 IDA
    oxidoreductase activity, acting on other nitrogenous compounds as donors GO:0016661 IDA
    chloride ion binding GO:0031404 IDA
    protein homodimerization activity GO:0042803 IPI
    FAD binding GO:0071949 IDA
    melatonin binding GO:1904408 IDA
    resveratrol binding GO:1905594 IDA
Biological Process
    quinone catabolic process GO:1901662 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified NQO2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for NQO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ELMO2 63916
Co-fractionation Homo sapiens
2 COPS5 10987
Affinity Capture-MS Homo sapiens
3 IL32  
Two-hybrid Homo sapiens
4 NXF1 10482
Affinity Capture-RNA Homo sapiens
5 CRAT 1384
Co-fractionation Homo sapiens
6 RPS6KA2  
Co-fractionation Homo sapiens
7 PARS2 25973
Affinity Capture-MS Homo sapiens
8 MOV10 4343
Affinity Capture-RNA Homo sapiens
9 MYC  
Dosage Lethality Homo sapiens
10 CENPF 1063
Co-fractionation Homo sapiens
11 NQO2 4835
Co-purification Homo sapiens
Co-purification Homo sapiens
12 NSF 4905
Affinity Capture-MS Homo sapiens
13 PRNP 5621
Affinity Capture-MS Homo sapiens
14 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 DDIT4L  
Two-hybrid Homo sapiens
16 DGCR6  
Two-hybrid Homo sapiens
17 LRRC7 57554
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NQO2 is involved
PathwayEvidenceSource
Biological oxidations TAS Reactome
Metabolism TAS Reactome
Phase I - Functionalization of compounds TAS Reactome





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