Gene description for RPH3A
Gene name rabphilin 3A
Gene symbol RPH3A
Other names/aliases -
Species Homo sapiens
 Database cross references - RPH3A
ExoCarta ExoCarta_22895
Entrez Gene 22895
HGNC 17056
MIM 612159
UniProt Q9Y2J0  
 RPH3A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RPH3A
Molecular Function
    clathrin binding GO:0030276 IBA
    calcium-dependent phospholipid binding GO:0005544 ISS
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
    syntaxin binding GO:0019905 IBA
    phosphatidylinositol phosphate binding GO:1901981 TAS
    protein binding GO:0005515 IPI
    selenium binding GO:0008430 ISS
    calcium ion binding GO:0005509 ISS
    Rab GTPase binding GO:0017137 IEA
    phosphate ion binding GO:0042301 ISS
    zinc ion binding GO:0008270 ISS
    inositol 1,4,5 trisphosphate binding GO:0070679 ISS
    protein complex binding GO:0032403 ISS
Biological Process
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    synaptic vesicle exocytosis GO:0016079 IBA
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    synapse GO:0045202 ISS
    neuron projection GO:0043005 ISS
    synaptic vesicle GO:0008021 TAS
    Golgi apparatus GO:0005794 ISS
    protein complex GO:0043234 ISS
    synaptic vesicle membrane GO:0030672 ISS
    cell junction GO:0030054 IEA
    extrinsic component of membrane GO:0019898 ISS
    secretory granule GO:0030141 ISS
    plasma membrane GO:0005886 IBA
    cytosol GO:0005829 ISS
 Experiment description of studies that identified RPH3A in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RPH3A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Reconstituted Complex Homo sapiens
2 RAB3B 5865
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 RAB8A 4218
Affinity Capture-Western Homo sapiens
4 GCH1  
Invivo Homo sapiens
5 RAB3A 5864
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
6 RAB3D 9545
Affinity Capture-Western Homo sapiens
7 ADD2 119
Invitro Homo sapiens
8 MLPH  
Affinity Capture-Western Homo sapiens
9 RAB26  
Affinity Capture-Western Homo sapiens
10 RAB27A 5873
Affinity Capture-Western Homo sapiens
11 RAB27B 5874
Affinity Capture-Western Homo sapiens
12 CASK 8573
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
13 RAB3C 115827
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which RPH3A is involved
No pathways found

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