Gene description for SYN2
Gene name synapsin II
Gene symbol SYN2
Other names/aliases SYNII
Species Homo sapiens
 Database cross references - SYN2
ExoCarta ExoCarta_6854
Entrez Gene 6854
HGNC 11495
MIM 600755
UniProt Q92777  
 SYN2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SYN2
Molecular Function
    ATP binding GO:0005524 TAS
    catalytic activity GO:0003824 IEA
Biological Process
    synaptic transmission GO:0007268 TAS
    neurotransmitter secretion GO:0007269 ISS
    metabolic process GO:0008152 IEA
Subcellular Localization
    synapse GO:0045202 ISS
    cell junction GO:0030054 IEA
    synaptic vesicle membrane GO:0030672 ISS
 Experiment description of studies that identified SYN2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SYN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYN1  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 SYN3  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 SYN2 6854
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 SNAP23 8773
Affinity Capture-Western Homo sapiens
5 CAPON  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SYN2 is involved
PathwayEvidenceSource
Dopamine Neurotransmitter Release Cycle TAS Reactome
Serotonin Neurotransmitter Release Cycle TAS Reactome





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