Gene description for UGGT2
Gene name UDP-glucose glycoprotein glucosyltransferase 2
Gene symbol UGGT2
Other names/aliases HUGT2
UGCGL2
UGT2
Species Homo sapiens
 Database cross references - UGGT2
ExoCarta ExoCarta_55757
Vesiclepedia VP_55757
Entrez Gene 55757
HGNC 15664
MIM 605898
UniProt Q9NYU1  
 UGGT2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UGGT2
Molecular Function
    UDP-glucose:glycoprotein glucosyltransferase activity GO:0003980 IBA
    UDP-glucose:glycoprotein glucosyltransferase activity GO:0003980 ISS
    UDP-glucose:glycoprotein glucosyltransferase activity GO:0003980 TAS
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 IBA
Biological Process
    protein N-linked glycosylation via asparagine GO:0018279 IBA
    ERAD pathway GO:0036503 IBA
    UDP-glucosylation GO:0097359 IEA
    endoplasmic reticulum mannose trimming GO:1904380 TAS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum lumen GO:0005788 ISS
    endoplasmic reticulum lumen GO:0005788 TAS
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
    protein-containing complex GO:0032991 IDA
    endoplasmic reticulum quality control compartment GO:0044322 IEA
 Experiment description of studies that identified UGGT2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UGGT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Affinity Capture-MS Homo sapiens
2 LYZL2  
Affinity Capture-MS Homo sapiens
3 LY6H  
Affinity Capture-MS Homo sapiens
4 LYPD6B 130576
Affinity Capture-MS Homo sapiens
5 METTL23  
Affinity Capture-MS Homo sapiens
6 WDR7 23335
Affinity Capture-MS Homo sapiens
7 HSPA5 3309
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 BTNL2  
Affinity Capture-MS Homo sapiens
9 NAAA  
Affinity Capture-MS Homo sapiens
10 ADAMTS4  
Affinity Capture-MS Homo sapiens
11 CEACAM8 1088
Affinity Capture-MS Homo sapiens
12 ITIH2 3698
Affinity Capture-MS Homo sapiens
13 UBE2H 7328
Affinity Capture-MS Homo sapiens
14 PI15  
Affinity Capture-MS Homo sapiens
15 CANX 821
Affinity Capture-MS Homo sapiens
16 NUDT12  
Affinity Capture-MS Homo sapiens
17 DNAJB12 54788
Proximity Label-MS Homo sapiens
18 THUMPD3 25917
Affinity Capture-MS Homo sapiens
19 LRRC59 55379
Proximity Label-MS Homo sapiens
20 PDIA4 9601
Proximity Label-MS Homo sapiens
21 IL25  
Affinity Capture-MS Homo sapiens
22 CALU 813
Proximity Label-MS Homo sapiens
23 CALR3  
Proximity Label-MS Homo sapiens
24 GGH 8836
Affinity Capture-MS Homo sapiens
25 PDGFRA 5156
Affinity Capture-MS Homo sapiens
26 EDEM1  
Affinity Capture-MS Homo sapiens
27 PRG2  
Affinity Capture-MS Homo sapiens
28 MFAP4 4239
Affinity Capture-MS Homo sapiens
29 AGMAT  
Affinity Capture-MS Homo sapiens
30 GPIHBP1  
Affinity Capture-MS Homo sapiens
31 CUL3 8452
Affinity Capture-MS Homo sapiens
32 FBXO6 26270
Affinity Capture-MS Homo sapiens
33 TARBP2  
Affinity Capture-MS Homo sapiens
34 OS9 10956
Affinity Capture-MS Homo sapiens
35 BRE 9577
Affinity Capture-MS Homo sapiens
36 EDEM2  
Affinity Capture-MS Homo sapiens
37 APPBP2  
Two-hybrid Homo sapiens
38 BABAM1 29086
Affinity Capture-MS Homo sapiens
39 TUBA4A 7277
Affinity Capture-MS Homo sapiens
40 BIRC6 57448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ADAMTS12 81792
Affinity Capture-MS Homo sapiens
42 IDS  
Affinity Capture-MS Homo sapiens
43 APP 351
Reconstituted Complex Homo sapiens
44 SORT1 6272
Affinity Capture-MS Homo sapiens
45 C1orf54  
Affinity Capture-MS Homo sapiens
46 BCHE 590
Affinity Capture-MS Homo sapiens
47 DNAJB9 4189
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 DNAJC10 54431
Proximity Label-MS Homo sapiens
49 DNAJC3 5611
Proximity Label-MS Homo sapiens
50 DHFRL1  
Affinity Capture-MS Homo sapiens
51 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
52 POGLUT1 56983
Affinity Capture-MS Homo sapiens
53 TRAV20  
Affinity Capture-MS Homo sapiens
54 HELLS 3070
Affinity Capture-MS Homo sapiens
55 SEC61B 10952
Proximity Label-MS Homo sapiens
56 UGGT1 56886
Cross-Linking-MS (XL-MS) Homo sapiens
57 DNAJB11 51726
Proximity Label-MS Homo sapiens
58 CPE 1363
Affinity Capture-MS Homo sapiens
59 PARN  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here