Gene description for SEMA6B
Gene name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Gene symbol SEMA6B
Other names/aliases SEM-SEMA-Y
SEMA-VIB
SEMAN
semaZ
Species Homo sapiens
 Database cross references - SEMA6B
ExoCarta ExoCarta_10501
Entrez Gene 10501
HGNC 10739
MIM 608873
UniProt Q9H3T3  
 SEMA6B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SEMA6B
Molecular Function
    semaphorin receptor binding GO:0030215 IEA
Biological Process
    cell differentiation GO:0030154 IEA
    nervous system development GO:0007399 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified SEMA6B in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SEMA6B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SEMA6B is involved
No pathways found





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