Gene description for ARHGAP21
Gene name Rho GTPase activating protein 21
Gene symbol ARHGAP21
Other names/aliases ARHGAP10
Species Homo sapiens
 Database cross references - ARHGAP21
ExoCarta ExoCarta_57584
Entrez Gene 57584
HGNC 23725
MIM 609870
UniProt Q5T5U3  
 ARHGAP21 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ARHGAP21
Molecular Function
    GTPase activator activity GO:0005096 IBA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    establishment of Golgi localization GO:0051683 IDA
    signal transduction GO:0007165 IEA
    maintenance of Golgi location GO:0051684 IMP
    Golgi organization GO:0007030 IMP
    organelle transport along microtubule GO:0072384 IMP
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
    Golgi apparatus GO:0005794 IDA
    Golgi membrane GO:0000139 IEA
    cell junction GO:0030054 IEA
 Experiment description of studies that identified ARHGAP21 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ARHGAP21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFN 2810
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ARHGAP21 is involved
No pathways found

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