Gene description for PLEKHA2
Gene name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
Gene symbol PLEKHA2
Other names/aliases TAPP2
Species Homo sapiens
 Database cross references - PLEKHA2
ExoCarta ExoCarta_59339
Vesiclepedia VP_59339
Entrez Gene 59339
HGNC 14336
MIM 607773
UniProt Q9HB19  
 PLEKHA2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PLEKHA2
Molecular Function
    fibronectin binding GO:0001968 IMP
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IBA
    PDZ domain binding GO:0030165 IEA
    laminin binding GO:0043236 IMP
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IBA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
Biological Process
    positive regulation of cell-matrix adhesion GO:0001954 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified PLEKHA2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PLEKHA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 RAB1B 81876
Affinity Capture-MS Homo sapiens
4 DTNB 1838
Affinity Capture-MS Homo sapiens
5 MCM7 4176
Affinity Capture-MS Homo sapiens
6 ARHGAP35 2909
Affinity Capture-MS Homo sapiens
7 SEC23A 10484
Affinity Capture-MS Homo sapiens
8 SNTG1  
Two-hybrid Homo sapiens
9 TUBA8 51807
Affinity Capture-MS Homo sapiens
10 UTRN 7402
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GIPC1 10755
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
12 RFTN1 23180
Affinity Capture-MS Homo sapiens
13 GRB2 2885
Affinity Capture-MS Homo sapiens
14 AHCYL1 10768
Affinity Capture-MS Homo sapiens
15 KANK2 25959
Two-hybrid Homo sapiens
16 PTPN6 5777
Affinity Capture-MS Homo sapiens
17 EGLN3  
Two-hybrid Homo sapiens
18 PLEKHA1 59338
Two-hybrid Homo sapiens
19 MCM5 4174
Affinity Capture-MS Homo sapiens
20 YWHAE 7531
Affinity Capture-MS Homo sapiens
21 KPNB1 3837
Affinity Capture-MS Homo sapiens
22 SNTB2 6645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MEX3A  
Affinity Capture-RNA Homo sapiens
24 TUBG1 7283
Affinity Capture-MS Homo sapiens
25 BRCA1 672
Affinity Capture-MS Homo sapiens
26 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
27 FHL5 9457
Two-hybrid Homo sapiens
28 DTNA  
Affinity Capture-MS Homo sapiens
29 YWHAZ 7534
Affinity Capture-MS Homo sapiens
30 UBE2Z 65264
Affinity Capture-MS Homo sapiens
31 LAMP2 3920
Affinity Capture-MS Homo sapiens
32 RAC2 5880
Affinity Capture-MS Homo sapiens
33 DMD 1756
Affinity Capture-MS Homo sapiens
34 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
35 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
36 CTNNAL1 8727
Affinity Capture-MS Homo sapiens
37 DDX58 23586
Affinity Capture-RNA Homo sapiens
38 RALA 5898
Affinity Capture-MS Homo sapiens
39 GIPC2 54810
Two-hybrid Homo sapiens
40 ACBD3 64746
Affinity Capture-MS Homo sapiens
41 CLTCL1 8218
Affinity Capture-MS Homo sapiens
42 GOLGA2 2801
Two-hybrid Homo sapiens
43 AHCYL2 23382
Affinity Capture-MS Homo sapiens
44 SNRNP200 23020
Affinity Capture-MS Homo sapiens
45 SNTA1 6640
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
46 COG6 57511
Two-hybrid Homo sapiens
47 TRIM28 10155
Affinity Capture-MS Homo sapiens
48 CDH1 999
Proximity Label-MS Homo sapiens
49 SLC25A4 291
Affinity Capture-MS Homo sapiens
50 TRIM23 373
Two-hybrid Homo sapiens
51 DDB1 1642
Affinity Capture-MS Homo sapiens
52 RAB7A 7879
Affinity Capture-MS Homo sapiens
53 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
54 RAD18  
Affinity Capture-MS Homo sapiens
55 AP2A1 160
Affinity Capture-MS Homo sapiens
56 COPB2 9276
Affinity Capture-MS Homo sapiens
57 SNRPB2 6629
Affinity Capture-MS Homo sapiens
58 M1AP  
Two-hybrid Homo sapiens
59 SEC24C 9632
Affinity Capture-MS Homo sapiens
60 FERMT3 83706
Affinity Capture-MS Homo sapiens
61 EPHA2 1969
Proximity Label-MS Homo sapiens
62 BANF1 8815
Affinity Capture-MS Homo sapiens
63 YWHAQ 10971
Affinity Capture-MS Homo sapiens
64 SNX27 81609
Affinity Capture-MS Homo sapiens
65 KRAS 3845
Affinity Capture-MS Homo sapiens
66 JMJD6 23210
Affinity Capture-MS Homo sapiens
67 CLTC 1213
Affinity Capture-MS Homo sapiens
68 YWHAG 7532
Affinity Capture-MS Homo sapiens
69 RPLP0 6175
Affinity Capture-MS Homo sapiens
70 HSF2BP  
Two-hybrid Homo sapiens
71 GIPC3  
Two-hybrid Homo sapiens
72 ENTHD2  
Two-hybrid Homo sapiens
73 SRSF3 6428
Affinity Capture-MS Homo sapiens
74 VDAC2 7417
Affinity Capture-MS Homo sapiens
75 MPDZ  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
76 SNTB1 6641
Affinity Capture-MS Homo sapiens
77 DLG2 1740
Two-hybrid Homo sapiens
78 EDRF1  
Affinity Capture-MS Homo sapiens
79 BRD4 23476
Affinity Capture-MS Homo sapiens
80 SLC25A5 292
Affinity Capture-MS Homo sapiens
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