ExoCarta: Gene summary

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Gene description for PLBD1
Gene name	phospholipase B domain containing 1
Gene symbol	PLBD1
Other names/aliases	-
Species	Homo sapiens
Database cross references - PLBD1
ExoCarta	ExoCarta_79887
Vesiclepedia	VP_79887
Entrez Gene	79887
HGNC	26215
UniProt	Q6P4A8
PLBD1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	34887515

Gene ontology annotations for PLBD1

Molecular Function
	phospholipase activity	GO:0004620	IBA
Biological Process
	phospholipid catabolic process	GO:0009395	IBA
Subcellular Localization
	extracellular region	GO:0005576	IBA
	extracellular space	GO:0005615	IDA
	lysosome	GO:0005764	IEA
	cytosol	GO:0005829	TAS

Experiment description of studies that identified PLBD1 in exosomes

Experiment ID

1203

MISEV standards
✔ EM	Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

"Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Protein-protein interactions for PLBD1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

PRSS16

10279

Affinity Capture-MS

Homo sapiens

SYMPK

8189

Affinity Capture-MS

Homo sapiens

NAB2

4665

Affinity Capture-MS

Homo sapiens

ABCF3

55324

Affinity Capture-MS

Homo sapiens

CCT7

10574

Affinity Capture-MS

Homo sapiens

SPICE1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VAV1

7409

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VPS41

27072

Affinity Capture-MS

Homo sapiens

ZNF154

Affinity Capture-MS

Homo sapiens

ASCC3

10973

Affinity Capture-MS

Homo sapiens

COASY

80347

Affinity Capture-MS

Homo sapiens

PPP2R2B

5521

Affinity Capture-MS

Homo sapiens

FOXK2

Affinity Capture-MS

Homo sapiens

SLC25A6

293

Affinity Capture-MS

Homo sapiens

SEP15

9403

Affinity Capture-MS

Homo sapiens

GTF3C5

9328

Affinity Capture-MS

Homo sapiens

POLE

Affinity Capture-MS

Homo sapiens

PDXDC1

23042

Affinity Capture-MS

Homo sapiens

RAD17

Affinity Capture-MS

Homo sapiens

CABS1

Affinity Capture-MS

Homo sapiens

CCT2

10576

Affinity Capture-MS

Homo sapiens

POLR2L

5441

Affinity Capture-MS

Homo sapiens

SH2D3A

Affinity Capture-MS

Homo sapiens

TBC1D22B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RNF31

55072

Affinity Capture-MS

Homo sapiens

ANAPC5

51433

Affinity Capture-MS

Homo sapiens

MICU3

Affinity Capture-MS

Homo sapiens

SLC35F2

54733

Affinity Capture-MS

Homo sapiens

MAPK8

5599

Affinity Capture-MS

Homo sapiens

IKBKG

8517

Affinity Capture-MS

Homo sapiens

VCPIP1

80124

Affinity Capture-MS

Homo sapiens

OR1N1

Affinity Capture-MS

Homo sapiens

PCP4

Affinity Capture-MS

Homo sapiens

ATP6AP2

10159

Affinity Capture-MS

Homo sapiens

OXSR1

9943

Affinity Capture-MS

Homo sapiens

CBWD1

55871

Affinity Capture-MS

Homo sapiens

DSCC1

Affinity Capture-MS

Homo sapiens

ZIC1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PTDSS1

9791

Affinity Capture-MS

Homo sapiens

FOXK1

221937

Affinity Capture-MS

Homo sapiens

FTH1

2495

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANKS1A

23294

Affinity Capture-MS

Homo sapiens

FANCA

Affinity Capture-MS

Homo sapiens

CCT6B

10693

Affinity Capture-MS

Homo sapiens

APP

351

Reconstituted Complex

Homo sapiens

PI4KA

5297

Affinity Capture-MS

Homo sapiens

RHBDD1

84236

Affinity Capture-MS

Homo sapiens

TRIP12

9320

Affinity Capture-MS

Homo sapiens

ZSWIM8

23053

Affinity Capture-MS

Homo sapiens

ERCC3

Affinity Capture-MS

Homo sapiens

ARMC6

93436

Affinity Capture-MS

Homo sapiens

GPATCH2L

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HDAC3

8841

Affinity Capture-MS

Homo sapiens

DNAAF5

54919

Affinity Capture-MS

Homo sapiens

PI4KAP1

Affinity Capture-MS

Homo sapiens

CCDC51

79714

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANKHD1

54882

Affinity Capture-MS

Homo sapiens

QRICH1

Affinity Capture-MS

Homo sapiens

PMVK

10654

Affinity Capture-MS

Homo sapiens

APAF1

317

Affinity Capture-MS

Homo sapiens

SARAF

Affinity Capture-MS

Homo sapiens

IL31RA

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TSPAN6

7105

Affinity Capture-MS

Homo sapiens

GOT1

2805

Affinity Capture-MS

Homo sapiens

BRAT1

221927

Affinity Capture-MS

Homo sapiens

CHTF18

63922

Affinity Capture-MS

Homo sapiens

ESRP2

80004

Affinity Capture-MS

Homo sapiens

NEIL2

Affinity Capture-MS

Homo sapiens

ATP6V1B1

525

Affinity Capture-MS

Homo sapiens

ARAP3

64411

Affinity Capture-MS

Homo sapiens

RGL3

Affinity Capture-MS

Homo sapiens

GMCL1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANKLE2

23141

Affinity Capture-MS

Homo sapiens

PHF8

Affinity Capture-MS

Homo sapiens

CCR1

Affinity Capture-MS

Homo sapiens

PPFIBP1

8496

Affinity Capture-MS

Homo sapiens

CHUK

1147

Affinity Capture-MS

Homo sapiens

STX17

55014

Affinity Capture-MS

Homo sapiens

TCP1

6950

Affinity Capture-MS

Homo sapiens

RIPPLY3

Affinity Capture-MS

Homo sapiens

CUL4A

8451

Affinity Capture-MS

Homo sapiens

UBXN6

80700

Affinity Capture-MS

Homo sapiens

C1orf146

Affinity Capture-MS

Homo sapiens

GPAT2

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which PLBD1 is involved

Pathway	Evidence	Source
Acyl chain remodelling of PC	TAS	Reactome
Acyl chain remodelling of PE	TAS	Reactome
Acyl chain remodelling of PI	TAS	Reactome
Glycerophospholipid biosynthesis	TAS	Reactome
Hydrolysis of LPC	TAS	Reactome
Metabolism	TAS	Reactome
Metabolism of lipids	TAS	Reactome
Phospholipid metabolism	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here