Gene description for FASLG
Gene name	Fas ligand (TNF superfamily, member 6)
Gene symbol	FASLG
Other names/aliases	ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6
Species	Homo sapiens
Database cross references - FASLG
ExoCarta	ExoCarta_356
Vesiclepedia	VP_356
Entrez Gene	356
HGNC	11936
MIM	134638
UniProt	P48023
FASLG identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells	15940614
Plasma	17076679
T cells	21252909

Gene ontology annotations for FASLG

Molecular Function     signaling receptor binding GO:0005102 TAS     death receptor binding GO:0005123 IEA     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IDA     tumor necrosis factor receptor binding GO:0005164 IEA     protein binding GO:0005515 IPI Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     apoptotic process GO:0006915 TAS     inflammatory cell apoptotic process GO:0006925 IEA     signal transduction GO:0007165 TAS     cell-cell signaling GO:0007267 TAS     positive regulation of cell population proliferation GO:0008284 IEA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IBA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     negative regulation of angiogenesis GO:0016525 IDA     intracellular chloride ion homeostasis GO:0030644 IEA     response to lipopolysaccharide GO:0032496 IEA     positive regulation of apoptotic process GO:0043065 IDA     positive regulation of apoptotic process GO:0043065 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEP     positive regulation of neuron apoptotic process GO:0043525 IEA     positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA     retinal cell programmed cell death GO:0046666 IEA     endosomal lumen acidification GO:0048388 IEA     T cell apoptotic process GO:0070231 IDA     necroptotic process GO:0070266 IDA     response to growth factor GO:0070848 IEA     cellular response to type II interferon GO:0071346 IEA     apoptotic signaling pathway GO:0097190 IDA     apoptotic signaling pathway GO:0097190 IMP     extrinsic apoptotic signaling pathway GO:0097191 IDA     necroptotic signaling pathway GO:0097527 IDA     release of sequestered calcium ion into cytosol by endoplasmic reticulum GO:1903514 IDA     positive regulation of phosphatidylserine exposure on apoptotic cell surface GO:1905782 IDA     positive regulation of endothelial cell apoptotic process GO:2000353 IDA     positive regulation of cysteine-type endopeptidase activity GO:2001056 IGI     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IBA Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IDA     nucleus GO:0005634 IDA     plasma membrane GO:0005886 IDA     caveola GO:0005901 IEA     external side of plasma membrane GO:0009897 IEA     lysosomal lumen GO:0043202 IEA     perinuclear region of cytoplasm GO:0048471 IEA     cytoplasmic vesicle lumen GO:0060205 IEA     extracellular exosome GO:0070062 IDA