Gene description for FASLG
Gene name	Fas ligand (TNF superfamily, member 6)
Gene symbol	FASLG
Other names/aliases	ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6
Species	Homo sapiens
Database cross references - FASLG
ExoCarta	ExoCarta_356
Entrez Gene	356
HGNC	11936
MIM	134638
UniProt	P48023
FASLG identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	15940614
Plasma	17076679
T cells	21252909

Gene ontology annotations for FASLG

Molecular Function     cytokine activity GO:0005125 IEA     protein binding GO:0005515 IPI     death receptor binding GO:0005123 IEA     tumor necrosis factor receptor binding GO:0005164 IEA     receptor binding GO:0005102 TAS Biological Process     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 TAS     programmed cell death GO:0012501 TAS     inflammatory cell apoptotic process GO:0006925 IEA     cell-cell signaling GO:0007267 TAS     positive regulation of endothelial cell apoptotic process GO:2000353 IDA     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 TAS     response to growth factor GO:0070848 IEA     negative regulation of angiogenesis GO:0016525 IDA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     transcription, DNA-templated GO:0006351 IEA     positive regulation of neuron apoptotic process GO:0043525 IEA     necroptotic signaling pathway GO:0097527 IDA     cellular chloride ion homeostasis GO:0030644 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     regulation of necrotic cell death GO:0010939 TAS     endosomal lumen acidification GO:0048388 IEA     extrinsic apoptotic signaling pathway GO:0097191 TAS     response to lipopolysaccharide GO:0032496 IEA     apoptotic signaling pathway GO:0097190 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 TAS     positive regulation of cell proliferation GO:0008284 IEA     cell surface receptor signaling pathway GO:0007166 TAS     apoptotic process GO:0006915 TAS     positive regulation of apoptotic process GO:0043065 IDA     necroptotic process GO:0070266 TAS     programmed necrotic cell death GO:0097300 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP     T cell apoptotic process GO:0070231 IDA     retinal cell programmed cell death GO:0046666 IEA     immune response GO:0006955 IEA     signal transduction GO:0007165 TAS     positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA Subcellular Localization     integral component of plasma membrane GO:0005887 TAS     caveola GO:0005901 IEA     external side of plasma membrane GO:0009897 IEA     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 IDA     extracellular space GO:0005615 IDA     lysosomal lumen GO:0043202 IEA     cytoplasmic membrane-bounded vesicle lumen GO:0060205 IEA     extracellular region GO:0005576 TAS     perinuclear region of cytoplasm GO:0048471 IEA     nucleus GO:0005634 IDA