Gene description for KRT71
Gene name keratin 71, type II
Gene symbol KRT71
Other names/aliases HYPT13
K6IRS1
KRT6IRS
KRT6IRS1
Species Homo sapiens
 Database cross references - KRT71
ExoCarta ExoCarta_112802
Vesiclepedia VP_112802
Entrez Gene 112802
HGNC 28927
MIM 608245
UniProt Q3SY84  
 KRT71 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for KRT71
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of skin epidermis GO:0030280 IBA
Biological Process
    hair follicle morphogenesis GO:0031069 IMP
    keratinization GO:0031424 IBA
    intermediate filament organization GO:0045109 IBA
    intermediate filament organization GO:0045109 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
    keratin filament GO:0045095 IPI
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT71 in exosomes
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRT71
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 KRT18 3875
Two-hybrid Homo sapiens
3 KRT37 8688
Two-hybrid Homo sapiens
4 KRT84 3890
Cross-Linking-MS (XL-MS) Homo sapiens
5 KRT33B 3884
Two-hybrid Homo sapiens
6 KRT25 147183
Two-hybrid Homo sapiens
7 KRT6A 3853
Cross-Linking-MS (XL-MS) Homo sapiens
8 KRT35 3886
Two-hybrid Homo sapiens
9 KRT8 3856
Cross-Linking-MS (XL-MS) Homo sapiens
10 KRT34  
Two-hybrid Homo sapiens
11 CUL3 8452
Affinity Capture-MS Homo sapiens
12 PRPH 5630
Cross-Linking-MS (XL-MS) Homo sapiens
13 KRT28 162605
Two-hybrid Homo sapiens
14 CUL4B 8450
Affinity Capture-MS Homo sapiens
15 EIF4A3 9775
Affinity Capture-MS Homo sapiens
16 RNF208  
Affinity Capture-MS Homo sapiens
17 KRT26 353288
Two-hybrid Homo sapiens
18 KRT27 342574
Two-hybrid Homo sapiens
19 EFNA3  
Affinity Capture-MS Homo sapiens
20 KRT15 3866
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 KRT24 192666
Two-hybrid Homo sapiens
22 KRT38 8687
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 KRT75 9119
Cross-Linking-MS (XL-MS) Homo sapiens
24 COPS5 10987
Affinity Capture-MS Homo sapiens
25 KRT40  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 KRT13 3860
Two-hybrid Homo sapiens
27 USHBP1  
Two-hybrid Homo sapiens
28 CCDC53 51019
Two-hybrid Homo sapiens
29 CUL2 8453
Affinity Capture-MS Homo sapiens
30 KRT19 3880
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
31 KRT5 3852
Cross-Linking-MS (XL-MS) Homo sapiens
32 KRT31 3881
Two-hybrid Homo sapiens
33 KRT16 3868
Two-hybrid Homo sapiens
34 CYLD  
Affinity Capture-MS Homo sapiens
35 APOA1 335
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which KRT71 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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