Gene description for SLC23A1
Gene name solute carrier family 23 (ascorbic acid transporter), member 1
Gene symbol SLC23A1
Other names/aliases SLC23A2
SVCT1
YSPL3
Species Homo sapiens
 Database cross references - SLC23A1
ExoCarta ExoCarta_9963
Entrez Gene 9963
HGNC 10974
MIM 603790
UniProt Q9UHI7  
 SLC23A1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SLC23A1
Molecular Function
    sodium-dependent L-ascorbate transmembrane transporter activity GO:0070890 IDA
    L-ascorbic acid transporter activity GO:0015229 IDA
    L-ascorbate:sodium symporter activity GO:0008520 IDA
    nucleobase transmembrane transporter activity GO:0015205 TAS
    dehydroascorbic acid transporter activity GO:0033300 IMP
    sodium ion transmembrane transporter activity GO:0015081 IDA
    protein binding GO:0005515 IPI
Biological Process
    vitamin metabolic process GO:0006766 TAS
    dehydroascorbic acid transport GO:0070837 IMP
    sodium ion transmembrane transport GO:0035725 IDA
    vitamin transmembrane transport GO:0035461 IEA
    L-ascorbic acid transport GO:0015882 IDA
    L-ascorbic acid metabolic process GO:0019852 TAS
    sodium ion transport GO:0006814 IDA
    response to toxic substance GO:0009636 IDA
    small molecule metabolic process GO:0044281 TAS
    brain development GO:0007420 ISS
    nucleobase-containing compound metabolic process GO:0006139 TAS
    water-soluble vitamin metabolic process GO:0006767 TAS
    transepithelial L-ascorbic acid transport GO:0070904 IDA
    nucleobase transport GO:0015851 TAS
    lung development GO:0030324 IEA
Subcellular Localization
    membrane GO:0016020 TAS
    extracellular exosome GO:0070062 IDA
    apical plasma membrane GO:0016324 IDA
    basal plasma membrane GO:0009925 IEA
    integral component of plasma membrane GO:0005887 TAS
    cytoplasm GO:0005737 ISS
    brush border GO:0005903 IEA
    plasma membrane GO:0005886 TAS
    intracellular organelle GO:0043229 IDA
 Experiment description of studies that identified SLC23A1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC23A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC23A1 is involved
PathwayEvidenceSource
Vitamin C (ascorbate) metabolism TAS Reactome





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