Gene description for LOH12CR1
Gene name loss of heterozygosity, 12, chromosomal region 1
Gene symbol LOH12CR1
Other names/aliases LOH1CR12
Species Homo sapiens
 Database cross references - LOH12CR1
ExoCarta ExoCarta_118426
Vesiclepedia VP_118426
Entrez Gene 118426
HGNC 17950
UniProt Q969J3  
 LOH12CR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LOH12CR1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    lysosome localization GO:0032418 IBA
    lysosome localization GO:0032418 IMP
    lysosome localization GO:0032418 NAS
    regulation of endosome size GO:0051036 NAS
    regulation of lysosome size GO:0062196 NAS
    organelle transport along microtubule GO:0072384 IBA
    organelle transport along microtubule GO:0072384 IMP
    organelle transport along microtubule GO:0072384 NAS
    positive regulation of anterograde synaptic vesicle transport GO:1903744 IBA
Subcellular Localization
    plus-end kinesin complex GO:0005873 IDA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IMP
    synaptic vesicle membrane GO:0030672 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytoplasmic side of lysosomal membrane GO:0098574 IBA
    cytoplasmic side of lysosomal membrane GO:0098574 IMP
    cytoplasmic side of lysosomal membrane GO:0098574 NAS
    BORC complex GO:0099078 IBA
    BORC complex GO:0099078 IDA
    BORC complex GO:0099078 IPI
 Experiment description of studies that identified LOH12CR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LOH12CR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LAMTOR4 389541
Affinity Capture-MS Homo sapiens
3 BRK1 55845
Affinity Capture-MS Homo sapiens
4 WHAMMP3  
Affinity Capture-MS Homo sapiens
5 TP53 7157
Negative Genetic Homo sapiens
6 BLOC1S6  
Affinity Capture-MS Homo sapiens
7 LAMTOR1 55004
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TEX35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 C15orf59  
Affinity Capture-MS Homo sapiens
10 RAB9A 9367
Proximity Label-MS Homo sapiens
11 FBXO25  
Affinity Capture-MS Homo sapiens
12 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
13 TRIML2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 IKBIP 121457
Affinity Capture-MS Homo sapiens
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 PUF60 22827
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 TMEM55B 90809
Affinity Capture-MS Homo sapiens
18 BCAS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 FAM9C  
Affinity Capture-MS Homo sapiens
20 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
21 KRT27 342574
Affinity Capture-MS Homo sapiens
22 LINC00238  
Two-hybrid Homo sapiens
23 C10orf32  
Affinity Capture-MS Homo sapiens
24 BLOC1S1  
Affinity Capture-MS Homo sapiens
25 VRK1 7443
Affinity Capture-MS Homo sapiens
26 RAB7A 7879
Proximity Label-MS Homo sapiens
27 MYPOP  
Affinity Capture-MS Homo sapiens
28 KXD1 79036
Affinity Capture-MS Homo sapiens
29 BICD1 636
Proximity Label-MS Homo sapiens
30 MEF2BNB  
Affinity Capture-MS Homo sapiens
31 LAMTOR3 8649
Affinity Capture-MS Homo sapiens
32 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LOH12CR1 is involved
No pathways found





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