Experiment description of studies that identified DISC1 in sEVs

1 Experiment ID 224 MISEV standards ✔ EM|AFM Biophysical techniques ✔ Alix|TSG101|CD63|CD81 Enriched markers ✔ GOLGA2 Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25944692     Organism Homo sapiens Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S" Journal name Oncotarget Publication year 2015 Sample Neuroblastoma cells Sample name SH-SY5Y Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.10 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting

Protein-protein interactions for DISC1

Protein Interactor ExoCarta ID Identification method PubMed Species 1 GABARAPL1 23710 Two-hybrid Homo sapiens 2 MVP 9961 Two-hybrid Homo sapiens 3 SUFU 51684 Two-hybrid Homo sapiens 4 KRT37 8688 Affinity Capture-MS Homo sapiens 5 DPYSL2 1808 Two-hybrid Homo sapiens 6 UTRN 7402 Two-hybrid Homo sapiens 7 MLLT10   Two-hybrid Homo sapiens 8 CCDC24   Two-hybrid Homo sapiens 9 ZNF124   Two-hybrid Homo sapiens 10 ATG9A 79065 Proximity Label-MS Homo sapiens 11 KIFC3 3801 Two-hybrid Homo sapiens 12 CEP170 9859 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 13 P4HA2 8974 Affinity Capture-MS Homo sapiens 14 MNS1 55329 Two-hybrid Homo sapiens 15 CELA1   Affinity Capture-MS Homo sapiens 16 DYNC1I1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 17 KCNQ5   Two-hybrid Homo sapiens 18 GRIPAP1 56850 Affinity Capture-MS Homo sapiens 19 SMC3 9126 Two-hybrid Homo sapiens 20 GAS8   Two-hybrid Homo sapiens 21 BFSP2   Two-hybrid Homo sapiens 22 XRN2 22803 Two-hybrid Homo sapiens 23 TTC23   Two-hybrid Homo sapiens 24 KIF7 374654 Affinity Capture-MS Homo sapiens 25 CCDC92   Two-hybrid Homo sapiens 26 CCDC102B   Two-hybrid Homo sapiens 27 STX11 8676 Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 28 NUP160 23279 Two-hybrid Homo sapiens 29 ARMC7   Two-hybrid Homo sapiens 30 ADO   Two-hybrid Homo sapiens 31 LAMC1 3915 Affinity Capture-MS Homo sapiens 32 NDE1 54820 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 33 CDC16 8881 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 34 C11orf30   Two-hybrid Homo sapiens 35 PPFIA3 8541 Two-hybrid Homo sapiens 36 CEP57L1   Two-hybrid Homo sapiens 37 EXOC1 55763 Two-hybrid Homo sapiens 38 BICD1 636 Two-hybrid Homo sapiens 39 NME7 29922 Two-hybrid Homo sapiens 40 NAV1 89796 Affinity Capture-MS Homo sapiens 41 MYT1L   Two-hybrid Homo sapiens 42 LENG1   Two-hybrid Homo sapiens 43 FAM83H 286077 Affinity Capture-MS Homo sapiens 44 RECK 8434 Two-hybrid Homo sapiens 45 TNIK 23043 Two-hybrid Homo sapiens 46 CCDC13 152206 Two-hybrid Homo sapiens 47 ZNF197   Two-hybrid Homo sapiens 48 GUSBP5   Affinity Capture-MS Homo sapiens 49 QARS 5859 Two-hybrid Homo sapiens 50 TFIP11   Two-hybrid Homo sapiens 51 STX18 53407 Two-hybrid Homo sapiens 52 GAS2L2   Two-hybrid Homo sapiens 53 AGTPBP1   Two-hybrid Homo sapiens 54 HERC2 8924 Affinity Capture-MS Homo sapiens 55 CRMP1 1400 Reconstituted Complex Homo sapiens 56 SMC5 23137 Two-hybrid Homo sapiens 57 DNAJC7 7266 Two-hybrid Homo sapiens 58 C8orf76   Affinity Capture-MS Homo sapiens 59 DDX6 1656 Two-hybrid Homo sapiens 60 PHF1   Two-hybrid Homo sapiens 61 YWHAG 7532 Two-hybrid Homo sapiens 62 CEP44   Affinity Capture-MS Homo sapiens 63 ARIH2 10425 Two-hybrid Homo sapiens 64 GNPTAB 79158 Two-hybrid Homo sapiens 65 EXOC7 23265 Two-hybrid Homo sapiens 66 CARD9 64170 Two-hybrid Homo sapiens 67 KIF3A 11127 Two-hybrid Homo sapiens 68 AP4E1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 69 TEX9   Affinity Capture-MS Homo sapiens 70 NECAB1   Two-hybrid Homo sapiens 71 IFT20 90410 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens 72 SMC2 10592 Two-hybrid Homo sapiens 73 TRIM37   Affinity Capture-MS Homo sapiens 74 KANSL1   Two-hybrid Homo sapiens 75 HERC2P2   Two-hybrid Homo sapiens 76 SPAG5 10615 Affinity Capture-MS Homo sapiens 77 FGFR1OP   Affinity Capture-MS Homo sapiens 78 SRGAP3   Two-hybrid Homo sapiens 79 OFD1 8481 Affinity Capture-MS Homo sapiens 80 ATF7IP 55729 Two-hybrid Homo sapiens 81 PLCG1 5335 Affinity Capture-MS Homo sapiens 82 PPP5C 5536 Two-hybrid Homo sapiens 83 TNKS 8658 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 84 RGPD5   Affinity Capture-MS Homo sapiens 85 PARK2   Affinity Capture-MS Homo sapiens 86 CTNNA3   Two-hybrid Homo sapiens 87 CLU 1191 Two-hybrid Homo sapiens 88 EXOC4 60412 Two-hybrid Homo sapiens 89 ATF4   Two-hybrid Homo sapiens 90 MPPED1   Two-hybrid Homo sapiens 91 TCL1B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 92 MCM10 55388 Affinity Capture-MS Homo sapiens 93 UBASH3B 84959 Two-hybrid Homo sapiens 94 GEM   Two-hybrid Homo sapiens 95 TSGA10   Two-hybrid Homo sapiens 96 MEMO1 51072 Two-hybrid Homo sapiens 97 YWHAE 7531 Two-hybrid Homo sapiens 98 AKAP9 10142 Two-hybrid Homo sapiens 99 SPARCL1   Two-hybrid Homo sapiens 100 AP4S1 11154 Affinity Capture-MS Homo sapiens 101 SYNE1 23345 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens 102 NUP62 23636 Affinity Capture-MS Homo sapiens 103 DCTN1 1639 Two-hybrid Homo sapiens 104 ZNF655   Affinity Capture-MS Homo sapiens 105 PKN1 5585 Two-hybrid Homo sapiens 106 YWHAQ 10971 Two-hybrid Homo sapiens 107 ANKHD1 54882 Affinity Capture-MS Homo sapiens 108 CCDC22 28952 Affinity Capture-MS Homo sapiens 109 STIL   Affinity Capture-MS Homo sapiens 110 FBLN5 10516 Affinity Capture-MS Homo sapiens 111 SMARCE1 6605 Two-hybrid Homo sapiens 112 GCC1 79571 Two-hybrid Homo sapiens 113 VPS18 57617 Affinity Capture-MS Homo sapiens 114 ACTG1 71 Two-hybrid Homo sapiens 115 RBSN 64145 Two-hybrid Homo sapiens 116 AIMP2 7965 Two-hybrid Homo sapiens 117 SYBU   Two-hybrid Homo sapiens 118 USP54 159195 Affinity Capture-MS Homo sapiens 119 TSR2   Two-hybrid Homo sapiens 120 ATF5   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 121 PPP4R1 9989 Two-hybrid Homo sapiens 122 C6orf165   Two-hybrid Homo sapiens 123 DST 667 Two-hybrid Homo sapiens 124 SH3BP5 9467 Two-hybrid Homo sapiens 125 RNF40 9810 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 126 CEP57   Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 127 TUBB 203068 Two-hybrid Homo sapiens 128 WHAMMP3   Affinity Capture-MS Homo sapiens 129 AGBL4   Affinity Capture-MS Homo sapiens 130 CCDC141   Two-hybrid Homo sapiens 131 CEP63   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 132 ZHX1-C8orf76   Affinity Capture-MS Homo sapiens 133 PPM1E   Two-hybrid Homo sapiens 134 BAG2 9532 Two-hybrid Homo sapiens 135 FSD1   Affinity Capture-MS Homo sapiens 136 ANGEL1   Affinity Capture-MS Homo sapiens 137 CCDC57 284001 Two-hybrid Homo sapiens 138 TCAF1 9747 Two-hybrid Homo sapiens 139 TRAF3IP1 26146 Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 140 PGK1 5230 Two-hybrid Homo sapiens 141 AP4M1 9179 Affinity Capture-MS Homo sapiens 142 SPTBN4 57731 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 143 SKP2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 144 YWHAZ 7534 Two-hybrid Homo sapiens 145 PRKD1 5587 Affinity Capture-MS Homo sapiens 146 SNX18 112574 Affinity Capture-MS Homo sapiens 147 TNKS2 80351 Affinity Capture-MS Homo sapiens 148 TRIM68 55128 Two-hybrid Homo sapiens 149 KIAA1377   Two-hybrid Homo sapiens 150 AP4B1   Affinity Capture-MS Homo sapiens 151 RABGAP1 23637 Two-hybrid Homo sapiens 152 DUSP16   Affinity Capture-MS Homo sapiens 153 GPRASP2   Two-hybrid Homo sapiens 154 SPTBN1 6711 Two-hybrid Homo sapiens 155 GNG13   Two-hybrid Homo sapiens 156 CEP164   Affinity Capture-MS Homo sapiens 157 RANBP9 10048 Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 158 GPANK1   Two-hybrid Homo sapiens 159 AKAP6   Two-hybrid Homo sapiens 160 PSPC1 55269 Two-hybrid Homo sapiens 161 CRYBA4   Affinity Capture-MS Homo sapiens 162 LIMD1 8994 Affinity Capture-MS Homo sapiens 163 TCEANC   Two-hybrid Homo sapiens 164 RIBC1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 165 C14orf80   Affinity Capture-MS Homo sapiens 166 TRIM27   Affinity Capture-MS Homo sapiens 167 KALRN 8997 Two-hybrid Homo sapiens 168 ACTN2 88 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 169 MATR3 9782 Two-hybrid Homo sapiens 170 AMOT 154796 Two-hybrid Homo sapiens 171 RFWD3   Affinity Capture-MS Homo sapiens 172 MYH7 4625 Two-hybrid Homo sapiens 173 PCM1 5108 Affinity Capture-MS Homo sapiens 174 P4HA3 283208 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 175 CCDC88A 55704 Two-hybrid Homo sapiens 176 KIF3C 3797 Two-hybrid Homo sapiens 177 CEP350 9857 Affinity Capture-MS Homo sapiens 178 SMYD1   Two-hybrid Homo sapiens 179 DPYSL3 1809 Two-hybrid Homo sapiens 180 RASSF7   Two-hybrid Homo sapiens 181 SNX6 58533 Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 182 CCDC136   Two-hybrid Homo sapiens 183 ALS2CR11   Two-hybrid Homo sapiens 184 HAUS3   Affinity Capture-MS Homo sapiens 185 LINC00521   Two-hybrid Homo sapiens 186 EIF3H 8667 Two-hybrid Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 187 IMMT 10989 Far Western Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Co-localization Homo sapiens Two-hybrid Homo sapiens 188 ROGDI 79641 Two-hybrid Homo sapiens 189 TUBB2A 7280 Two-hybrid Homo sapiens 190 TRIO 7204 Two-hybrid Homo sapiens 191 FEZ1   Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 192 FBXO34   Two-hybrid Homo sapiens 193 ASB3 51130 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 194 SPTAN1 6709 Two-hybrid Homo sapiens 195 ZSCAN23   Affinity Capture-MS Homo sapiens 196 BCAS2 10286 Affinity Capture-MS Homo sapiens 197 COL4A1 1282 Two-hybrid Homo sapiens 198 ITSN1 6453 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 199 PDE4B   Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 200 C8orf33 65265 Two-hybrid Homo sapiens 201 OLFM1   Two-hybrid Homo sapiens 202 UBASH3A 53347 Two-hybrid Homo sapiens 203 MACF1 23499 Two-hybrid Homo sapiens 204 CCHCR1   Two-hybrid Homo sapiens 205 RGPD8   Affinity Capture-MS Homo sapiens 206 FRYL 285527 Two-hybrid Homo sapiens 207 TRIM52   Affinity Capture-MS Homo sapiens 208 POLR3C 10623 Two-hybrid Homo sapiens 209 BZRAP1   Two-hybrid Homo sapiens 210 CDC37 11140 Two-hybrid Homo sapiens 211 NME2P1 283458 Affinity Capture-MS Homo sapiens 212 SNX29   Affinity Capture-MS Homo sapiens 213 WDR62   Affinity Capture-MS Homo sapiens 214 MORF4L2   Two-hybrid Homo sapiens 215 DCTN2 10540 Two-hybrid Homo sapiens 216 CWF19L2   Two-hybrid Homo sapiens 217 RNF20 56254 Affinity Capture-MS Homo sapiens 218 EIF4A3 9775 Two-hybrid Homo sapiens 219 GNB1 2782 Two-hybrid Homo sapiens 220 KIFAP3 22920 Two-hybrid Homo sapiens 221 TRIP11 9321 Affinity Capture-MS Homo sapiens 222 PCNXL4 64430 Two-hybrid Homo sapiens 223 ALMS1   Affinity Capture-MS Homo sapiens 224 BRK1 55845 Affinity Capture-MS Homo sapiens 225 DYNC1H1 1778 Two-hybrid Homo sapiens 226 EEF2 1938 Two-hybrid Homo sapiens 227 ZNF318 24149 Affinity Capture-MS Homo sapiens 228 FBXO41   Two-hybrid Homo sapiens 229 ABI2 10152 Two-hybrid Homo sapiens 230 N4BP2   Affinity Capture-MS Homo sapiens 231 KRT38 8687 Affinity Capture-MS Homo sapiens 232 RAD21 5885 Two-hybrid Homo sapiens 233 SPATC1L   Two-hybrid Homo sapiens 234 C1orf109   Two-hybrid Homo sapiens 235 MYF6   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 236 CIT 11113 Two-hybrid Homo sapiens 237 CDK5RAP3 80279 Two-hybrid Homo sapiens 238 NDEL1 81565 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 239 C14orf166 51637 Two-hybrid Homo sapiens 240 SRGAP2 23380 Two-hybrid Homo sapiens 241 MAP1A 4130 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 242 Srr   Affinity Capture-Western Mus musculus 243 DMD 1756 Two-hybrid Homo sapiens 244 PAFAH1B1 5048 Two-hybrid Homo sapiens 245 NEFM 4741 Two-hybrid Homo sapiens 246 TRIM29 23650 Two-hybrid Homo sapiens 247 TIAM2 26230 Two-hybrid Homo sapiens 248 ALS2CR12   Two-hybrid Homo sapiens 249 PRMT1 3276 Affinity Capture-MS Homo sapiens 250 PIK3R3 8503 Two-hybrid Homo sapiens 251 SRR 63826 Affinity Capture-Western Homo sapiens 252 PUSL1   Affinity Capture-MS Homo sapiens 253 C17orf59 54785 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens 254 XPNPEP1 7511 Two-hybrid Homo sapiens 255 CDC5L 988 Two-hybrid Homo sapiens 256 ZNF365   Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens View the network

Pathways in which DISC1 is involved

No pathways found