Gene description for DISC1
Gene name disrupted in schizophrenia 1
Gene symbol DISC1
Other names/aliases C1orf136
SCZD9
Species Homo sapiens
 Database cross references - DISC1
ExoCarta ExoCarta_27185
Entrez Gene 27185
HGNC 2888
MIM 605210
UniProt Q9NRI5  
 DISC1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DISC1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of neuron projection development GO:0010975 IEA
    positive regulation of Wnt signaling pathway GO:0030177 IGI
    microtubule cytoskeleton organization GO:0000226 IMP
    cerebral cortex radially oriented cell migration GO:0021799 IEA
    cellular protein localization GO:0034613 IEA
    positive regulation of neuroblast proliferation GO:0002052 IGI
    mitochondrial calcium ion homeostasis GO:0051560 IEA
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IEA
    canonical Wnt signaling pathway GO:0060070 IEA
    neuron migration GO:0001764 IMP
    cell proliferation in forebrain GO:0021846 IEA
    regulation of synapse maturation GO:0090128 IEA
    TOR signaling GO:0031929 IEA
Subcellular Localization
    centrosome GO:0005813 IDA
    ciliary basal body GO:0036064 IEA
    postsynaptic density GO:0014069 IEA
    cell junction GO:0030054 IEA
    postsynaptic membrane GO:0045211 IEA
    microtubule GO:0005874 IEA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified DISC1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DISC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATF5  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 EIF3A 8661
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 FEZ1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 COL4A1 1282
Two-hybrid Homo sapiens
5 ITSN1 6453
Two-hybrid Homo sapiens
6 Cep63  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 TRAF3IP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 ATF7IP 55729
Two-hybrid Homo sapiens
9 SPTBN4 57731
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 KCNQ5  
Two-hybrid Homo sapiens
11 SYNE1 23345
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
12 MYO1A 4640
Two-hybrid Homo sapiens
13 C11orf13  
Two-hybrid Homo sapiens
14 KIAA1377  
Two-hybrid Homo sapiens
15 ATF4  
Two-hybrid Homo sapiens
16 RANBP9 10048
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
17 FLJ39502  
Two-hybrid Homo sapiens
18 NDEL1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
19 CIT 11113
Two-hybrid Homo sapiens
20 ACTN2 88
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
21 MAP1A 4130
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
22 YWHAG 7532
Two-hybrid Homo sapiens
23 EIF3H 8667
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DISC1 is involved
No pathways found





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