Gene description for PAN3
Gene name PAN3 poly(A) specific ribonuclease subunit
Gene symbol PAN3
Other names/aliases -
Species Homo sapiens
 Database cross references - PAN3
ExoCarta ExoCarta_255967
Entrez Gene 255967
HGNC 29991
UniProt Q58A45  
 PAN3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for PAN3
Molecular Function
    poly(A) RNA binding GO:0044822 IEA
    ATP binding GO:0005524 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    poly(A)-specific ribonuclease activity GO:0004535 IDA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
Biological Process
    gene expression GO:0010467 TAS
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 IDA
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 TAS
    positive regulation of cytoplasmic mRNA processing body assembly GO:0010606 IEA
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    protein targeting GO:0006605 IEA
    deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasmic mRNA processing body GO:0000932 IEA
    PAN complex GO:0031251 IDA
 Experiment description of studies that identified PAN3 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for PAN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAN2  
Affinity Capture-Western Homo sapiens
2 ETF1 2107
Reconstituted Complex Homo sapiens
3 PABPC1 26986
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PAN3 is involved
Deadenylation of mRNA TAS Reactome

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