Gene description for ACACB
Gene name acetyl-CoA carboxylase beta
Gene symbol ACACB
Other names/aliases ACC2
ACCB
HACC275
Species Homo sapiens
 Database cross references - ACACB
ExoCarta ExoCarta_32
Vesiclepedia VP_32
Entrez Gene 32
HGNC 85
MIM 601557
UniProt O00763  
 ACACB identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ACACB
Molecular Function
    acetyl-CoA carboxylase activity GO:0003989 IBA
    acetyl-CoA carboxylase activity GO:0003989 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 IEA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    acetyl-CoA metabolic process GO:0006084 IDA
    pentose-phosphate shunt GO:0006098 IEA
    fatty acid biosynthetic process GO:0006633 IBA
    response to nutrient GO:0007584 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    positive regulation of lipid storage GO:0010884 IEA
    regulation of glucose metabolic process GO:0010906 IEA
    response to organic cyclic compound GO:0014070 IEA
    fatty acid oxidation GO:0019395 IEA
    negative regulation of fatty acid beta-oxidation GO:0031999 IEA
    D-glucose import GO:0046323 IEA
    lactic acid secretion GO:0046722 IEA
    protein homotetramerization GO:0051289 IDA
    positive regulation of heart growth GO:0060421 IEA
    tricarboxylic acid metabolic process GO:0072350 IEA
    intracellular aspartate homeostasis GO:0090459 IEA
    intracellular glutamate homeostasis GO:0090461 IEA
    energy homeostasis GO:0097009 IEA
    regulation of cardiac muscle hypertrophy in response to stress GO:1903242 IEA
    malonyl-CoA biosynthetic process GO:2001295 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 TAS
    cytosol GO:0005829 TAS
    mitochondrial fatty acid beta-oxidation multienzyme complex GO:0016507 IEA
 Experiment description of studies that identified ACACB in exosomes
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACACB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 PRKAA1 5562
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 GSK3A 2931
Affinity Capture-MS Homo sapiens
5 SLU7  
Affinity Capture-MS Homo sapiens
6 ARF4 378
Proximity Label-MS Homo sapiens
7 HPCAL4  
Affinity Capture-MS Homo sapiens
8 GSK3B 2932
Affinity Capture-MS Homo sapiens
9 DUSP22  
Affinity Capture-MS Homo sapiens
10 NR3C1 2908
Proximity Label-MS Homo sapiens
11 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
12 RFWD2  
Affinity Capture-MS Homo sapiens
13 C1orf106  
Affinity Capture-MS Homo sapiens
14 GRK7  
Affinity Capture-MS Homo sapiens
15 BAG5 9529
Affinity Capture-MS Homo sapiens
16 DOCK5 80005
Affinity Capture-MS Homo sapiens
17 NPTXR 23467
Affinity Capture-MS Homo sapiens
18 TACC1 6867
Affinity Capture-MS Homo sapiens
19 MID1IP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NT5DC1 221294
Affinity Capture-MS Homo sapiens
21 ELP3 55140
Affinity Capture-MS Homo sapiens
22 EVA1C  
Affinity Capture-MS Homo sapiens
23 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
24 RGS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 BCDIN3D  
Affinity Capture-MS Homo sapiens
26 EGFR 1956
Affinity Capture-MS Homo sapiens
27 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
28 HOOK3 84376
Proximity Label-MS Homo sapiens
29 ACAA1 30
Affinity Capture-MS Homo sapiens
30 IFNE  
Affinity Capture-MS Homo sapiens
31 ANKRD28 23243
Proximity Label-MS Homo sapiens
32 THRSP  
Affinity Capture-MS Homo sapiens
33 SAMD3  
Affinity Capture-MS Homo sapiens
34 MLF1  
Affinity Capture-MS Homo sapiens
35 DPPA4  
Affinity Capture-MS Homo sapiens
36 ACACA 31
Affinity Capture-MS Homo sapiens
37 TMEM154  
Affinity Capture-MS Homo sapiens
38 EPHA2 1969
Proximity Label-MS Homo sapiens
39 FOS 2353
Proximity Label-MS Homo sapiens
40 RPA3 6119
Proximity Label-MS Homo sapiens
41 SLX4  
Affinity Capture-MS Homo sapiens
42 MRPL46  
Affinity Capture-MS Homo sapiens
43 CCDC107  
Affinity Capture-MS Homo sapiens
44 PPARD  
Affinity Capture-MS Homo sapiens
45 DTX2 113878
Proximity Label-MS Homo sapiens
46 IDS  
Affinity Capture-MS Homo sapiens
47 TSSK4 283629
Affinity Capture-MS Homo sapiens
48 PCGF1 84759
Affinity Capture-MS Homo sapiens
49 NXPH3  
Affinity Capture-MS Homo sapiens
50 POU5F1  
Affinity Capture-MS Homo sapiens
51 GPRC5B 51704
Affinity Capture-MS Homo sapiens
52 TRNT1 51095
Cross-Linking-MS (XL-MS) Homo sapiens
53 NANOG  
Affinity Capture-MS Homo sapiens
54 NPAP1  
Affinity Capture-MS Homo sapiens
55 GBAP1  
Affinity Capture-MS Homo sapiens
56 ALS2CR11  
Affinity Capture-MS Homo sapiens
57 HUWE1 10075
Affinity Capture-MS Homo sapiens
58 HLCS  
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
59 BCOR  
Affinity Capture-MS Homo sapiens
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