Gene description for LAMTOR5
Gene name late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Gene symbol LAMTOR5
Other names/aliases HBXIP
XIP
Species Homo sapiens
 Database cross references - LAMTOR5
ExoCarta ExoCarta_10542
Vesiclepedia VP_10542
Entrez Gene 10542
HGNC 17955
MIM 608521
UniProt O43504  
 LAMTOR5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LAMTOR5
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    protein binding GO:0005515 IPI
    molecular adaptor activity GO:0060090 IDA
Biological Process
    regulation of cell size GO:0008361 IMP
    response to virus GO:0009615 TAS
    positive regulation of gene expression GO:0010628 IGI
    viral genome replication GO:0019079 TAS
    positive regulation of TOR signaling GO:0032008 IMP
    positive regulation of interleukin-8 production GO:0032757 IGI
    TORC1 signaling GO:0038202 NAS
    negative regulation of apoptotic process GO:0043066 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IGI
    protein localization to lysosome GO:0061462 IMP
    cellular response to amino acid stimulus GO:0071230 IBA
    cellular response to amino acid stimulus GO:0071230 IDA
    cellular response to amino acid stimulus GO:0071230 IMP
    positive regulation of protein localization to nucleus GO:1900182 IDA
    positive regulation of TORC1 signaling GO:1904263 IBA
    positive regulation of TORC1 signaling GO:1904263 IDA
    positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1905636 IDA
    negative regulation of cysteine-type endopeptidase activity GO:2000117 IDA
Subcellular Localization
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IDA
    lysosomal membrane GO:0005765 NAS
    lysosomal membrane GO:0005765 TAS
    cytosol GO:0005829 IDA
    late endosome membrane GO:0031902 NAS
    protein-containing complex GO:0032991 IDA
    Ragulator complex GO:0071986 IBA
    Ragulator complex GO:0071986 IDA
    Ragulator complex GO:0071986 IPI
    FNIP-folliculin RagC/D GAP GO:1990877 IDA
 Experiment description of studies that identified LAMTOR5 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LAMTOR5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 NCOA6  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 HMCES  
Affinity Capture-MS Homo sapiens
4 TOP2B 7155
Two-hybrid Homo sapiens
5 ATP6V1C1 528
Co-fractionation Homo sapiens
6 E2F1 1869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 ALB 213
Two-hybrid Homo sapiens
8 NKIRAS2  
Affinity Capture-MS Homo sapiens
9 RRAGD 58528
Affinity Capture-MS Homo sapiens
10 TRMT6 51605
Affinity Capture-MS Homo sapiens
11 TRIM55  
Two-hybrid Homo sapiens
12 GFM2 84340
Affinity Capture-MS Homo sapiens
13 SLC38A9  
Affinity Capture-MS Homo sapiens
14 BLOC1S1  
Affinity Capture-MS Homo sapiens
15 CDC16 8881
Affinity Capture-MS Homo sapiens
16 TAF9 6880
Two-hybrid Homo sapiens
17 SNAPIN 23557
Affinity Capture-MS Homo sapiens
18 CEP70  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 TGFB1 7040
Two-hybrid Homo sapiens
20 SLC31A1 1317
Affinity Capture-MS Homo sapiens
21 TSEN15 116461
Affinity Capture-MS Homo sapiens
22 NR1H2  
Affinity Capture-MS Homo sapiens
23 LAMTOR3 8649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MTHFD2L 441024
Affinity Capture-MS Homo sapiens
25 INPP5F  
Affinity Capture-MS Homo sapiens
26 SERPINA1 5265
Two-hybrid Homo sapiens
27 LAMTOR4 389541
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
28 TFCP2 7024
Affinity Capture-MS Homo sapiens
29 BHMT 635
Two-hybrid Homo sapiens
30 STX12 23673
Affinity Capture-MS Homo sapiens
31 LAMTOR1 55004
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GBA2  
Affinity Capture-MS Homo sapiens
33 PDK1 5163
Two-hybrid Homo sapiens
34 GPRASP1  
Two-hybrid Homo sapiens
35 RBP4 5950
Two-hybrid Homo sapiens
36 DNLZ  
Affinity Capture-MS Homo sapiens
37 UTP14A 10813
Two-hybrid Homo sapiens
38 CD74 972
Two-hybrid Homo sapiens
39 ZBTB16  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 NR1H3  
Affinity Capture-MS Homo sapiens
41 TMEM55B 90809
Affinity Capture-MS Homo sapiens
42 RRAGB 10325
Affinity Capture-MS Homo sapiens
43 LRIF1  
Two-hybrid Homo sapiens
44 VRK1 7443
Affinity Capture-MS Homo sapiens
45 UBP1 7342
Affinity Capture-MS Homo sapiens
46 GIT1 28964
Two-hybrid Homo sapiens
47 GORASP2 26003
Co-fractionation Homo sapiens
48 GAPDH 2597
Two-hybrid Homo sapiens
49 MEOX2  
Two-hybrid Homo sapiens
50 PLXDC2 84898
Affinity Capture-MS Homo sapiens
51 MEF2BNB  
Affinity Capture-MS Homo sapiens
52 SLC18B1 116843
Affinity Capture-MS Homo sapiens
53 RABIF  
Two-hybrid Homo sapiens
54 ERI3 79033
Affinity Capture-MS Homo sapiens
55 TRIM63  
Two-hybrid Homo sapiens
56 Slain1  
Affinity Capture-MS Mus musculus
57 TCAP  
Two-hybrid Homo sapiens
58 C9 735
Two-hybrid Homo sapiens
59 HSPA5 3309
Co-fractionation Homo sapiens
60 GFER  
Affinity Capture-MS Homo sapiens
61 SORT1 6272
Affinity Capture-MS Homo sapiens
62 RRAGA 10670
Affinity Capture-MS Homo sapiens
63 MAF1  
Two-hybrid Homo sapiens
64 LAMP1 3916
Affinity Capture-MS Homo sapiens
65 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
66 KIAA1377  
Two-hybrid Homo sapiens
67 TTF2 8458
Affinity Capture-MS Homo sapiens
68 NXF1 10482
Affinity Capture-RNA Homo sapiens
69 YTHDC1  
Two-hybrid Homo sapiens
70 SGTB  
Affinity Capture-MS Homo sapiens
71 USP47 55031
Affinity Capture-MS Homo sapiens
72 LOH12CR1 118426
Affinity Capture-MS Homo sapiens
73 DSTN 11034
Co-fractionation Homo sapiens
74 MOB2 81532
Affinity Capture-MS Homo sapiens
75 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
76 FHL2 2274
Affinity Capture-MS Homo sapiens
77 RRAGC 64121
Affinity Capture-MS Homo sapiens
78 BIRC5  
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
79 EEF1A1 1915
Two-hybrid Homo sapiens
80 FASN 2194
Positive Genetic Homo sapiens
81 ASGR1 432
Two-hybrid Homo sapiens
82 BLOC1S2 282991
Affinity Capture-MS Homo sapiens
83 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
84 SIN3A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 STK38 11329
Affinity Capture-MS Homo sapiens
86 Rbm8a  
Affinity Capture-MS Mus musculus
87 KEAP1 9817
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
88 RPTOR 57521
Affinity Capture-MS Homo sapiens
89 RPL23 9349
Affinity Capture-MS Homo sapiens
90 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 MT2A 4502
Two-hybrid Homo sapiens
92 FNIP2  
Affinity Capture-MS Homo sapiens
93 STK38L 23012
Affinity Capture-MS Homo sapiens
94 C10orf32  
Affinity Capture-MS Homo sapiens
95 MOV10 4343
Affinity Capture-RNA Homo sapiens
96 BAG6 7917
Affinity Capture-MS Homo sapiens
97 PMVK 10654
Affinity Capture-MS Homo sapiens
98 DBI 1622
Two-hybrid Homo sapiens
99 ITPA 3704
Affinity Capture-MS Homo sapiens
100 KLHL6  
Co-localization Homo sapiens
101 KXD1 79036
Affinity Capture-MS Homo sapiens
102 LDLR 3949
Positive Genetic Homo sapiens
103 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
104 CFB 629
Two-hybrid Homo sapiens
105 NUFIP2 57532
Affinity Capture-Western Homo sapiens
106 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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