Gene description for CPS1
Gene name carbamoyl-phosphate synthase 1, mitochondrial
Gene symbol CPS1
Other names/aliases CPSASE1
PHN
Species Homo sapiens
 Database cross references - CPS1
ExoCarta ExoCarta_1373
Entrez Gene 1373
HGNC 2323
MIM 608307
UniProt P31327  
 CPS1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CPS1
Molecular Function
    calcium ion binding GO:0005509 IEA
    glutamate binding GO:0016595 IEA
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IEA
    ATP binding GO:0005524 IEA
    modified amino acid binding GO:0072341 IDA
    carbamoyl-phosphate synthase (ammonia) activity GO:0004087 IMP
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004088 IBA
    endopeptidase activity GO:0004175 IEA
    protein complex binding GO:0032403 IEA
Biological Process
    response to starvation GO:0042594 IEA
    cellular response to fibroblast growth factor stimulus GO:0044344 IEA
    cellular response to oleic acid GO:0071400 IEA
    nitric oxide metabolic process GO:0046209 IMP
    response to lipopolysaccharide GO:0032496 IDA
    homocysteine metabolic process GO:0050667 IDA
    carbamoyl phosphate biosynthetic process GO:0070409 IMP
    response to amine GO:0014075 IEA
    response to toxic substance GO:0009636 IEA
    cellular response to glucagon stimulus GO:0071377 IEA
    citrulline biosynthetic process GO:0019240 NAS
    glycogen catabolic process GO:0005980 IMP
    response to amino acid GO:0043200 IEA
    hepatocyte differentiation GO:0070365 IEA
    anion homeostasis GO:0055081 IEA
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    small molecule metabolic process GO:0044281 TAS
    midgut development GO:0007494 IEA
    arginine biosynthetic process GO:0006526 IBA
    glutamine metabolic process GO:0006541 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    positive regulation of vasodilation GO:0045909 IMP
    response to dexamethasone GO:0071548 IEA
    response to food GO:0032094 IEA
    cellular response to cAMP GO:0071320 IEA
    triglyceride catabolic process GO:0019433 IMP
    proteolysis GO:0006508 IEA
    urea cycle GO:0000050 TAS
    response to drug GO:0042493 IEA
    response to zinc ion GO:0010043 IEA
    response to growth hormone GO:0060416 IEA
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    mitochondrial nucleoid GO:0042645 IDA
    protein complex GO:0043234 IEA
    mitochondrial inner membrane GO:0005743 IEA
    cytoplasm GO:0005737 IBA
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified CPS1 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CPS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CPS1 is involved
PathwayEvidenceSource
Urea cycle TAS Reactome





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