Gene description for MAD2L1
Gene name MAD2 mitotic arrest deficient-like 1 (yeast)
Gene symbol MAD2L1
Other names/aliases HSMAD2
MAD2
Species Homo sapiens
 Database cross references - MAD2L1
ExoCarta ExoCarta_4085
Vesiclepedia VP_4085
Entrez Gene 4085
HGNC 6763
MIM 601467
UniProt Q13257  
 MAD2L1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MAD2L1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    mitotic sister chromatid segregation GO:0000070 IEA
    establishment of mitotic spindle orientation GO:0000132 IMP
    mitotic spindle assembly checkpoint signaling GO:0007094 IBA
    mitotic spindle assembly checkpoint signaling GO:0007094 IDA
    mitotic spindle assembly checkpoint signaling GO:0007094 NAS
    negative regulation of protein catabolic process GO:0042177 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of mitotic cell cycle GO:0045930 IMP
    cell division GO:0051301 IEA
    establishment of centrosome localization GO:0051660 IMP
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 IDA
    positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 IMP
    negative regulation of ubiquitin protein ligase activity GO:1904667 IDA
Subcellular Localization
    kinetochore GO:0000776 IDA
    kinetochore GO:0000776 IDA
    spindle pole GO:0000922 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    mitotic checkpoint complex GO:0033597 IPI
    nuclear pore nuclear basket GO:0044615 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    mitotic spindle GO:0072686 IDA
    mitotic spindle assembly checkpoint MAD1-MAD2 complex GO:1990728 IPI
 Experiment description of studies that identified MAD2L1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MAD2L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 C15orf39  
Affinity Capture-MS Homo sapiens
3 ZSCAN29  
Affinity Capture-MS Homo sapiens
4 GTF2F1 2962
Affinity Capture-MS Homo sapiens
5 CDC26 246184
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZNF8  
Affinity Capture-MS Homo sapiens
7 ABL2  
Affinity Capture-MS Homo sapiens
8 DGCR14  
Affinity Capture-MS Homo sapiens
9 SPRTN  
Affinity Capture-MS Homo sapiens
10 ETV6  
Affinity Capture-MS Homo sapiens
11 CUEDC2  
Affinity Capture-Western Homo sapiens
12 RPS3A 6189
Affinity Capture-MS Homo sapiens
13 PRIM2 5558
Affinity Capture-MS Homo sapiens
14 BUB1  
Protein-peptide Homo sapiens
15 IPO7 10527
Affinity Capture-MS Homo sapiens
16 RPA2 6118
Proximity Label-MS Homo sapiens
17 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
18 ANAPC5 51433
Affinity Capture-MS Homo sapiens
19 NSL1  
Co-localization Homo sapiens
20 APC  
Affinity Capture-Western Homo sapiens
21 INSR 3643
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
22 BUB1B  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ZZZ3  
Affinity Capture-MS Homo sapiens
24 MAD2L1BP  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RBM41  
Affinity Capture-MS Homo sapiens
26 CHFR  
Affinity Capture-Western Homo sapiens
27 AAR2 25980
Affinity Capture-MS Homo sapiens
28 KIF7 374654
Affinity Capture-MS Homo sapiens
29 PUS3  
Affinity Capture-MS Homo sapiens
30 APP 351
Reconstituted Complex Homo sapiens
31 TAF5  
Affinity Capture-MS Homo sapiens
32 ELL  
Affinity Capture-MS Homo sapiens
33 MGA  
Affinity Capture-MS Homo sapiens
34 CAPZB 832
Affinity Capture-MS Homo sapiens
35 UBD  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 MBIP  
Affinity Capture-MS Homo sapiens
37 SRCAP  
Affinity Capture-MS Homo sapiens
38 CDC16 8881
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
39 SLC26A4 5172
Affinity Capture-MS Homo sapiens
40 GTF2F2 2963
Affinity Capture-MS Homo sapiens
41 ZBTB21  
Affinity Capture-MS Homo sapiens
42 EPM2AIP1 9852
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
43 RNF8  
Affinity Capture-MS Homo sapiens
44 KDM2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TFAP4 7023
Affinity Capture-MS Homo sapiens
46 CHD8 57680
Affinity Capture-MS Homo sapiens
47 PRIM1  
Affinity Capture-MS Homo sapiens
48 MDC1  
Affinity Capture-MS Homo sapiens
49 ADAM15 8751
Affinity Capture-Western Homo sapiens
50 KCTD21 283219
Affinity Capture-MS Homo sapiens
51 MAD2L2 10459
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
52 L3MBTL2  
Affinity Capture-MS Homo sapiens
53 CHMP2B 25978
Affinity Capture-MS Homo sapiens
54 BOD1L1 259282
Affinity Capture-MS Homo sapiens
55 Ncstn 59287
Affinity Capture-MS Mus musculus
56 MAP4K5 11183
Affinity Capture-MS Homo sapiens
57 DYNLL1 8655
Affinity Capture-MS Homo sapiens
58 PEAK1 79834
Affinity Capture-MS Homo sapiens
59 TAF7  
Affinity Capture-MS Homo sapiens
60 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ANAPC7 51434
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 YEATS2  
Affinity Capture-MS Homo sapiens
63 BPTF 2186
Affinity Capture-MS Homo sapiens
64 SETD1A 9739
Affinity Capture-MS Homo sapiens
65 SDCBP 6386
Two-hybrid Homo sapiens
66 MAD2L1 4085
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
67 SGOL2 151246
Affinity Capture-MS Homo sapiens
68 MTA2 9219
Affinity Capture-MS Homo sapiens
69 Mad2l1  
Affinity Capture-Western Rattus norvegicus
70 NOL11  
Affinity Capture-MS Homo sapiens
71 Mad2l1bp  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
72 BAG5 9529
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
73 AURKA 6790
Affinity Capture-MS Homo sapiens
74 CXXC1  
Affinity Capture-MS Homo sapiens
75 GEMIN5 25929
Affinity Capture-MS Homo sapiens
76 ATF7IP 55729
Affinity Capture-MS Homo sapiens
77 CDC23 8697
Affinity Capture-MS Homo sapiens
78 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 CTDP1 9150
Affinity Capture-MS Homo sapiens
80 LUZP1 7798
Affinity Capture-MS Homo sapiens
81 C6orf47  
Affinity Capture-MS Homo sapiens
82 HIVEP1 3096
Affinity Capture-MS Homo sapiens
83 ZNF318 24149
Affinity Capture-MS Homo sapiens
84 PNN 5411
Affinity Capture-MS Homo sapiens
85 PRKAG1 5571
Affinity Capture-MS Homo sapiens
86 PPIP5K2 23262
Affinity Capture-MS Homo sapiens
87 POLA2  
Affinity Capture-MS Homo sapiens
88 TRIM24  
Affinity Capture-MS Homo sapiens
89 FANCM 57697
Affinity Capture-MS Homo sapiens
90 CSF2RB  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
91 TAF9B  
Affinity Capture-MS Homo sapiens
92 TBC1D32 221322
Proximity Label-MS Homo sapiens
93 UBR5 51366
Affinity Capture-Western Homo sapiens
94 CIRH1A 84916
Affinity Capture-MS Homo sapiens
95 BTF3 689
Affinity Capture-MS Homo sapiens
96 BCL7C  
Affinity Capture-MS Homo sapiens
97 SLX4  
Affinity Capture-MS Homo sapiens
98 Gm9174  
Affinity Capture-MS Mus musculus
99 ARNT 405
Affinity Capture-MS Homo sapiens
100 WDR43 23160
Affinity Capture-MS Homo sapiens
101 CIC 23152
Affinity Capture-MS Homo sapiens
102 ANAPC4 29945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 MBD3 53615
Affinity Capture-MS Homo sapiens
104 SKP2  
Affinity Capture-MS Homo sapiens
105 DAXX  
Affinity Capture-Western Homo sapiens
106 TSR2  
Affinity Capture-MS Homo sapiens
107 BDH2 56898
Affinity Capture-MS Homo sapiens
108 OPHN1  
Affinity Capture-MS Homo sapiens
109 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
110 TRIP13 9319
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
111 TPX2  
Affinity Capture-MS Homo sapiens
112 MTA3 57504
Affinity Capture-MS Homo sapiens
113 MIER1  
Affinity Capture-MS Homo sapiens
114 TUBB 203068
Affinity Capture-MS Homo sapiens
115 CCNA2 890
Protein-peptide Homo sapiens
116 HIST1H3A 8350
Reconstituted Complex Homo sapiens
117 Cdc23  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
118 SMARCAD1  
Affinity Capture-MS Homo sapiens
119 CHD9 80205
Affinity Capture-MS Homo sapiens
120 ZNHIT1  
Affinity Capture-MS Homo sapiens
121 PPM1E  
Affinity Capture-MS Homo sapiens
122 NUBP2 10101
Affinity Capture-MS Homo sapiens
123 TPR 7175
Affinity Capture-MS Homo sapiens
124 MAD1L1  
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
125 PSMD8 5714
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
126 PRKAA2 5563
Affinity Capture-MS Homo sapiens
127 SETX  
Affinity Capture-MS Homo sapiens
128 DAB2IP 153090
Affinity Capture-Western Homo sapiens
129 CSRP2BP  
Affinity Capture-MS Homo sapiens
130 C1orf52  
Affinity Capture-MS Homo sapiens
131 CKAP2  
Affinity Capture-MS Homo sapiens
132 ERCC4  
Affinity Capture-MS Homo sapiens
133 ADNP 23394
Affinity Capture-MS Homo sapiens
134 TP73  
Affinity Capture-Western Homo sapiens
135 KLHL13 90293
Affinity Capture-MS Homo sapiens
136 GAB1  
Affinity Capture-MS Homo sapiens
137 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
138 Cdc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
139 SF3A1 10291
Affinity Capture-MS Homo sapiens
140 KDM3B  
Affinity Capture-MS Homo sapiens
141 DMAP1 55929
Affinity Capture-MS Homo sapiens
142 CDYL 9425
Affinity Capture-MS Homo sapiens
143 ZW10 9183
Co-localization Homo sapiens
144 TADA2A  
Affinity Capture-MS Homo sapiens
145 RABAC1 10567
Two-hybrid Homo sapiens
146 RPA3 6119
Proximity Label-MS Homo sapiens
147 ABCF2 10061
Affinity Capture-MS Homo sapiens
148 EHMT2 10919
Affinity Capture-MS Homo sapiens
149 PRSS8 5652
Affinity Capture-MS Homo sapiens
150 SART3 9733
Affinity Capture-MS Homo sapiens
151 RAF1 5894
Affinity Capture-MS Homo sapiens
152 Bub1b 12236
Affinity Capture-MS Mus musculus
153 RNF2  
Affinity Capture-MS Homo sapiens
154 APEX2  
Affinity Capture-MS Homo sapiens
155 CCDC88A 55704
Affinity Capture-MS Homo sapiens
156 MIER2  
Affinity Capture-MS Homo sapiens
157 Mad2l1 56150
Affinity Capture-MS Mus musculus
158 WIBG 84305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 EIF4G2 1982
Affinity Capture-MS Homo sapiens
160 SUPT20H 55578
Affinity Capture-MS Homo sapiens
161 KIF20A 10112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 ADAM10 102
Affinity Capture-Western Homo sapiens
163 DDX46 9879
Affinity Capture-MS Homo sapiens
164 LBR 3930
Affinity Capture-MS Homo sapiens
165 Anapc2  
Affinity Capture-MS Mus musculus
166 MED19  
Affinity Capture-MS Homo sapiens
167 ADAM17 6868
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
168 ESR2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
169 CDC20 991
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 KAT2A  
Affinity Capture-MS Homo sapiens
171 TRPS1  
Affinity Capture-MS Homo sapiens
172 FBXL6  
Affinity Capture-MS Homo sapiens
173 TRIM33 51592
Affinity Capture-MS Homo sapiens
174 MACF1 23499
Affinity Capture-MS Homo sapiens
175 TRMT10A 93587
Affinity Capture-MS Homo sapiens
176 DSTYK 25778
Affinity Capture-MS Homo sapiens
177 ANAPC16  
Affinity Capture-MS Homo sapiens
178 SLC39A7 7922
Affinity Capture-MS Homo sapiens
179 KEAP1 9817
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
180 ADNP2  
Affinity Capture-MS Homo sapiens
181 ACTR6  
Affinity Capture-MS Homo sapiens
182 NCOA2 10499
Affinity Capture-MS Homo sapiens
183 OXSR1 9943
Affinity Capture-MS Homo sapiens
184 UBE2C 11065
Co-fractionation Homo sapiens
185 ANAPC1 64682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 CHD4 1108
Affinity Capture-MS Homo sapiens
187 WDR35 57539
Affinity Capture-MS Homo sapiens
188 TOR1AIP1 26092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 BUB3 9184
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
190 PRR12 57479
Affinity Capture-MS Homo sapiens
191 Cdc20  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
192 ANAPC2 29882
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
193 STK25 10494
Affinity Capture-MS Homo sapiens
194 PPP1R9A  
Affinity Capture-MS Homo sapiens
195 BSG 682
Affinity Capture-MS Homo sapiens
196 NEK2  
Affinity Capture-Western Homo sapiens
197 SMYD2 56950
Affinity Capture-MS Homo sapiens
198 CAD 790
Affinity Capture-MS Homo sapiens
199 HSF1  
Affinity Capture-Western Homo sapiens
200 RAB7A 7879
Proximity Label-MS Homo sapiens
201 UBXN4 23190
Affinity Capture-MS Homo sapiens
202 TSC22D4 81628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
203 SF3A3 10946
Affinity Capture-MS Homo sapiens
204 LIN54  
Affinity Capture-MS Homo sapiens
205 POLA1  
Affinity Capture-MS Homo sapiens
206 SERBP1 26135
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
207 EHMT1  
Affinity Capture-MS Homo sapiens
208 KRAS 3845
Negative Genetic Homo sapiens
209 C9orf72  
Affinity Capture-MS Homo sapiens
210 ATXN3 4287
Affinity Capture-MS Homo sapiens
211 PHF8  
Affinity Capture-MS Homo sapiens
212 VPS72  
Affinity Capture-MS Homo sapiens
213 NUDT5 11164
Affinity Capture-MS Homo sapiens
214 NDUFS6  
Affinity Capture-MS Homo sapiens
215 WDHD1  
Affinity Capture-MS Homo sapiens
216 DCAF5  
Affinity Capture-MS Homo sapiens
217 REV3L  
Reconstituted Complex Homo sapiens
218 FLG2 388698
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAD2L1 is involved
PathwayEvidenceSource
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal TAS Reactome
Amplification of signal from the kinetochores TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
EML4 and NUDC in mitotic spindle formation TAS Reactome
Inactivation of APC/C via direct inhibition of the APC/C complex TAS Reactome
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components TAS Reactome
M Phase TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Prometaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
Resolution of Sister Chromatid Cohesion TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate Formins TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome





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