Gene description for TBXA2R
Gene name thromboxane A2 receptor
Gene symbol TBXA2R
Other names/aliases BDPLT13
TXA2-R
Species Homo sapiens
 Database cross references - TBXA2R
ExoCarta ExoCarta_6915
Vesiclepedia VP_6915
Entrez Gene 6915
HGNC 11608
MIM 188070
UniProt P21731  
 TBXA2R identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for TBXA2R
Molecular Function
    thromboxane A2 receptor activity GO:0004961 TAS
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
Biological Process
    smooth muscle contraction GO:0006939 IEA
    inflammatory response GO:0006954 IBA
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IBA
    response to nutrient GO:0007584 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    positive regulation of blood coagulation GO:0030194 IEA
    response to testosterone GO:0033574 IEA
    thromboxane A2 signaling pathway GO:0038193 IEA
    response to ethanol GO:0045471 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    positive regulation of blood pressure GO:0045777 IBA
    positive regulation of vasoconstriction GO:0045907 IBA
    positive regulation of smooth muscle contraction GO:0045987 IEA
    cellular response to lipopolysaccharide GO:0071222 IEA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IGI
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified TBXA2R in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBXA2R
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
2 PTGIR  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
3 PRDX4 10549
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 GRK5 2869
Biochemical Activity Homo sapiens
5 SLC19A2 10560
Affinity Capture-MS Homo sapiens
6 ARRB2 409
Affinity Capture-Western Homo sapiens
7 GNG2 54331
FRET Homo sapiens
8 GNA12 2768
Affinity Capture-Western Homo sapiens
9 PTPRD 5789
Affinity Capture-MS Homo sapiens
10 GRK6 2870
Biochemical Activity Homo sapiens
11 PLCB2  
Affinity Capture-Western Homo sapiens
12 SIDT2 51092
Affinity Capture-MS Homo sapiens
13 YWHAZ 7534
Two-hybrid Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 GLMN 11146
Affinity Capture-MS Homo sapiens
15 NDFIP2 54602
Affinity Capture-MS Homo sapiens
16 PSME3 10197
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
18 NME2 4831
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
19 SIVA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 SC5D 6309
Affinity Capture-MS Homo sapiens
21 MBOAT7 79143
Affinity Capture-MS Homo sapiens
22 GNAQ 2776
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 TMEM186  
Affinity Capture-MS Homo sapiens
24 BMPR1A 657
Affinity Capture-MS Homo sapiens
25 RPGRIP1L 23322
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
26 LRRC10  
Affinity Capture-MS Homo sapiens
27 GNB1 2782
FRET Homo sapiens
Reconstituted Complex Homo sapiens
28 TBXA2R 6915
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-localization Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
FRET Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-localization Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
FRET Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
29 WDR36 134430
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
30 SLC25A24 29957
Affinity Capture-MS Homo sapiens
31 GNA11 2767
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 PDXDC2P  
Affinity Capture-MS Homo sapiens
33 KCNMA1 3778
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 GNAS 2778
FRET Homo sapiens
35 FAM134C 162427
Affinity Capture-MS Homo sapiens
36 PSMA7 5688
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 SLC27A3 11000
Affinity Capture-MS Homo sapiens
38 FGFR1 2260
Affinity Capture-MS Homo sapiens
39 PRKCA 5578
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
40 RAB11A 8766
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
41 GHRL  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
42 RAF1 5894
Affinity Capture-Western Homo sapiens
43 GNA13 10672
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
44 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
45 GNB2L1 10399
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
46 GNAI2 2771
FRET Homo sapiens
47 KIDINS220 57498
Affinity Capture-MS Homo sapiens
48 AAMP 14
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
49 GPRASP1  
Reconstituted Complex Homo sapiens
50 KCNMB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here