Gene description for RBL2
Gene name retinoblastoma-like 2
Gene symbol RBL2
Other names/aliases P130
Rb2
Species Homo sapiens
 Database cross references - RBL2
ExoCarta ExoCarta_5934
Entrez Gene 5934
HGNC 9894
MIM 180203
UniProt Q08999  
 RBL2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for RBL2
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
Biological Process
    regulation of lipid kinase activity GO:0043550 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IEA
    transcription, DNA-templated GO:0006351 IEA
    chromatin modification GO:0016568 IEA
    mitotic cell cycle GO:0000278 TAS
    regulation of cell cycle GO:0051726 IEA
Subcellular Localization
    transcription factor complex GO:0005667 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified RBL2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for RBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Affinity Capture-Western Homo sapiens
2 E2F4  
Invivo Homo sapiens
Invitro Homo sapiens
3 BRF2  
Invivo Homo sapiens
4 RAF1 5894
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 MCM7 4176
Reconstituted Complex Homo sapiens
6 UBTF 7343
Invivo Homo sapiens
7 SUV39H1  
Affinity Capture-Western Homo sapiens
8 CDK2 1017
Biochemical Activity Homo sapiens
Invitro Homo sapiens
9 BRCA1 672
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
10 E2F5  
Invivo Homo sapiens
Co-purification Homo sapiens
11 CCNA2 890
Affinity Capture-Western Homo sapiens
12 CCNE1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 SKIIP  
Reconstituted Complex Homo sapiens
14 RBBP9  
Invivo Homo sapiens
15 HBP1  
Two-hybrid Homo sapiens
16 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 PHB 5245
Invivo Homo sapiens
Invitro Homo sapiens
18 AATF  
Affinity Capture-Western Homo sapiens
19 TAF1  
Invitro Homo sapiens
Invivo Homo sapiens
20 RBBP8  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RBL2 is involved
PathwayEvidenceSource
Cyclin D associated events in G1 TAS Reactome
G0 and Early G1 TAS Reactome





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