Gene description for CD84
Gene name CD84 molecule
Gene symbol CD84
Other names/aliases LY9B
SLAMF5
hCD84
mCD84
Species Homo sapiens
 Database cross references - CD84
ExoCarta ExoCarta_8832
Vesiclepedia VP_8832
Entrez Gene 8832
HGNC 1704
MIM 604513
UniProt Q9UIB8  
 CD84 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for CD84
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    adaptive immune response GO:0002250 IEA
    autophagy GO:0006914 IEA
    defense response GO:0006952 TAS
    immune response GO:0006955 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 TAS
    negative regulation of granulocyte macrophage colony-stimulating factor production GO:0032685 IDA
    negative regulation of interleukin-18 production GO:0032701 IDA
    negative regulation of mast cell activation GO:0033004 IDA
    T cell activation GO:0042110 IBA
    negative regulation of mast cell degranulation GO:0043305 IDA
    innate immune response GO:0045087 IEA
    regulation of store-operated calcium entry GO:2001256 IDA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified CD84 in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD84
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SH2D1B  
Affinity Capture-Western Homo sapiens
2 PTPN11 5781
Affinity Capture-Western Homo sapiens
3 CUL3 8452
Affinity Capture-MS Homo sapiens
4 SH2D1A 4068
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 CD84 8832
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
6 Sh2d1b1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which CD84 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Hemostasis TAS Reactome





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