Gene description for FCGRT
Gene name Fc fragment of IgG, receptor, transporter, alpha
Gene symbol FCGRT
Other names/aliases FCRN
alpha-chain
Species Homo sapiens
 Database cross references - FCGRT
ExoCarta ExoCarta_2217
Entrez Gene 2217
HGNC 3621
MIM 601437
UniProt P55899  
 FCGRT identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FCGRT
Molecular Function
    IgG receptor activity GO:0019770 IBA
    IgG binding GO:0019864 IDA
    beta-2-microglobulin binding GO:0030881 IBA
    antigen binding GO:0003823 IBA
Biological Process
    antigen processing and presentation GO:0019882 IBA
    Fc-gamma receptor signaling pathway GO:0038094 IBA
    IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor GO:0002416 NAS
    immune response GO:0006955 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified FCGRT in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FCGRT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 B2M 567
Invitro Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
2 ALB 213
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which FCGRT is involved
No pathways found





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