Gene description for SDHC
Gene name succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Gene symbol SDHC
Other names/aliases CYB560
CYBL
PGL3
QPS1
SDH3
Species Homo sapiens
 Database cross references - SDHC
ExoCarta ExoCarta_6391
Vesiclepedia VP_6391
Entrez Gene 6391
HGNC 10682
MIM 602413
UniProt Q99643  
 SDHC identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SDHC
Molecular Function
    protein binding GO:0005515 IPI
    electron transfer activity GO:0009055 IEA
    heme binding GO:0020037 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    tricarboxylic acid cycle GO:0006099 IEA
    tricarboxylic acid cycle GO:0006099 NAS
    tricarboxylic acid cycle GO:0006099 TAS
    mitochondrial electron transport, succinate to ubiquinone GO:0006121 IBA
    mitochondrial electron transport, succinate to ubiquinone GO:0006121 NAS
    aerobic respiration GO:0009060 TAS
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 TAS
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    membrane GO:0016020 TAS
    respiratory chain complex II (succinate dehydrogenase) GO:0045273 IBA
    respiratory chain complex II (succinate dehydrogenase) GO:0045273 IDA
    respiratory chain complex II (succinate dehydrogenase) GO:0045273 ISS
    respiratory chain complex II (succinate dehydrogenase) GO:0045273 TAS
 Experiment description of studies that identified SDHC in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SDHC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UNK  
Affinity Capture-RNA Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 SDHD  
Affinity Capture-MS Homo sapiens
4 XRCC6 2547
Two-hybrid Homo sapiens
5 ARHGDIA 396
Two-hybrid Homo sapiens
6 RIT1 6016
Negative Genetic Homo sapiens
7 APEX1 328
Affinity Capture-RNA Homo sapiens
8 KRAS 3845
Negative Genetic Homo sapiens
9 RBFOX2 23543
Two-hybrid Homo sapiens
10 MTCH2 23788
Co-fractionation Homo sapiens
11 Fubp3  
Two-hybrid Mus musculus
12 EGFR 1956
Negative Genetic Homo sapiens
13 DHODH 1723
Affinity Capture-MS Homo sapiens
14 MDM2  
Two-hybrid Homo sapiens
15 SDHB 6390
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
16 Htatsf1  
Two-hybrid Mus musculus
17 SDHA 6389
Co-fractionation Homo sapiens
18 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 NDUFS2 4720
Co-fractionation Homo sapiens
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