Gene description for STAP2
Gene name signal transducing adaptor family member 2
Gene symbol STAP2
Other names/aliases BKS
Species Homo sapiens
 Database cross references - STAP2
ExoCarta ExoCarta_55620
Vesiclepedia VP_55620
Entrez Gene 55620
HGNC 30430
MIM 607881
UniProt Q9UGK3  
 STAP2 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for STAP2
Molecular Function
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified STAP2 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for STAP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YES1 7525
Two-hybrid Homo sapiens
2 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 BLK 640
Two-hybrid Homo sapiens
4 SERPINB1 1992
Co-fractionation Homo sapiens
5 PADI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PTBP1 5725
Co-fractionation Homo sapiens
7 PTK6  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
8 IKBKB 3551
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
10 CHUK 1147
Affinity Capture-Western Homo sapiens
11 CSF1R  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 PTK2 5747
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 MYD88 4615
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 BPNT1 10380
Co-fractionation Homo sapiens
15 MLH1 4292
Two-hybrid Homo sapiens
View the network image/svg+xml



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