Gene description for TAGLN
Gene name
transgelin
Gene symbol
TAGLN
Other names/aliases
SM22 SMCC TAGLN1 WS3-10
Species
Homo sapiens
Database cross references - TAGLN
ExoCarta
ExoCarta_6876
Entrez Gene
6876
HGNC
11553
MIM
600818
UniProt
Q01995
TAGLN identified in exosomes derived from the following tissue/cell type
Hepatocytes
26054723
Mesenchymal stem cells
Unpublished / Not applicable
Gene ontology annotations for TAGLN
Experiment description of studies that identified TAGLN in exosomes
1
Experiment ID
237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocytes
Sample name
MIHA
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RNA Sequencing
2
Experiment ID
126
ISEV standards
✘
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry [LTQ-FT Ultra]
PubMed ID
Unpublished / Not applicable
Organism
Homo sapiens
Experiment description
Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors
Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name
Mesenchymal Stem Cell Therapy
Publication year
2011
Sample
Mesenchymal stem cells
Sample name
huES9.E1
Isolation/purification methods
HPLC
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Antobody array Mass spectrometry
Protein-protein interactions for TAGLN
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
S100A9
6280
Affinity Capture-MS
Homo sapiens
2
CFL1
1072
Affinity Capture-MS
Homo sapiens
3
ACTA1
58
Affinity Capture-MS
Homo sapiens
Co-fractionation
Homo sapiens
4
GIPC1
10755
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which TAGLN is involved
No pathways found