Gene description for SKAP1
Gene name src kinase associated phosphoprotein 1
Gene symbol SKAP1
Other names/aliases HEL-S-81p
Species Homo sapiens
 Database cross references - SKAP1
ExoCarta ExoCarta_8631
Entrez Gene 8631
HGNC 15605
MIM 604969
UniProt Q86WV1  
 SKAP1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SKAP1
Molecular Function
    SH2 domain binding GO:0042169 IDA
    protein kinase binding GO:0019901 IPI
    SH3/SH2 adaptor activity GO:0005070 IC
    protein complex binding GO:0032403 IEA
    protein phosphatase binding GO:0019903 IPI
    SH3 domain binding GO:0017124 TAS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of signal transduction GO:0009967 IC
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    T cell receptor signaling pathway GO:0050852 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SKAP1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SKAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Reconstituted Complex Homo sapiens
2 FYB 2533
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 SRC 6714
Reconstituted Complex Homo sapiens
4 LCK 3932
Reconstituted Complex Homo sapiens
5 FYN 2534
Reconstituted Complex Homo sapiens
6 GRB2 2885
Invivo Homo sapiens
7 PTPRC 5788
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SKAP1 is involved
No pathways found

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