Gene description for CD3E
Gene name	CD3e molecule, epsilon (CD3-TCR complex)
Gene symbol	CD3E
Other names/aliases	IMD18 T3E TCRE
Species	Homo sapiens
Database cross references - CD3E
ExoCarta	ExoCarta_916
Entrez Gene	916
HGNC	1674
MIM	186830
UniProt	P07766
CD3E identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for CD3E

Molecular Function     SH3 domain binding GO:0017124 IPI     protein binding GO:0005515 IPI     transmembrane signaling receptor activity GO:0004888 NAS     receptor signaling protein activity GO:0005057 TAS     protein kinase binding GO:0019901 NAS     T cell receptor binding GO:0042608 NAS     receptor signaling complex scaffold activity GO:0030159 NAS     protein heterodimerization activity GO:0046982 IPI Biological Process     positive regulation of interleukin-2 biosynthetic process GO:0045086 IEA     positive regulation of alpha-beta T cell proliferation GO:0046641 IEA     regulation of apoptotic process GO:0042981 NAS     protein complex assembly GO:0006461 NAS     regulation of immune response GO:0050776 TAS     G-protein coupled receptor signaling pathway GO:0007186 TAS     positive regulation of T cell proliferation GO:0042102 IMP     T cell costimulation GO:0031295 TAS     response to nutrient GO:0007584 IEA     positive regulation of T cell anergy GO:0002669 IEA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     positive regulation of interferon-gamma production GO:0032729 IEA     positive regulation of interleukin-4 production GO:0032753 IEA     T cell receptor signaling pathway GO:0050852 TAS     signal complex assembly GO:0007172 TAS     apoptotic signaling pathway GO:0097190 IEA     intracellular signal transduction GO:0035556 TAS     cell surface receptor signaling pathway GO:0007166 NAS     negative regulation of smoothened signaling pathway GO:0045879 IEA     positive regulation of calcium-mediated signaling GO:0050850 IEA     T cell activation GO:0042110 NAS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     negative thymic T cell selection GO:0045060 IEA Subcellular Localization     immunological synapse GO:0001772 IEA     plasma membrane GO:0005886 TAS     integral component of plasma membrane GO:0005887 NAS     T cell receptor complex GO:0042101 NAS     external side of plasma membrane GO:0009897 IDA     cell-cell junction GO:0005911 IEA     intracellular GO:0005622 TAS     alpha-beta T cell receptor complex GO:0042105 IEA