Gene description for AXL
Gene name	AXL receptor tyrosine kinase
Gene symbol	AXL
Other names/aliases	ARK JTK11 Tyro7 UFO
Species	Homo sapiens
Database cross references - AXL
ExoCarta	ExoCarta_558
Entrez Gene	558
HGNC	905
MIM	109135
UniProt	P30530
AXL identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Melanoma cells	25950383
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for AXL

Molecular Function     protein binding GO:0005515 IPI     myosin heavy chain binding GO:0032036 IEA     phosphatidylinositol 3-kinase binding GO:0043548 IEA     ATP binding GO:0005524 IEA     protein tyrosine kinase activity GO:0004713 EXP     transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA     protein heterodimerization activity GO:0046982 IEA     phosphatidylserine binding GO:0001786 IDA Biological Process     negative regulation of lymphocyte activation GO:0051250 IEA     viral entry into host cell GO:0046718 IMP     negative regulation of neuron apoptotic process GO:0043524 IEA     natural killer cell differentiation GO:0001779 IEA     negative regulation of tumor necrosis factor production GO:0032720 IEA     organ regeneration GO:0031100 IEA     neuron migration GO:0001764 IEA     innate immune response GO:0045087 IEA     cellular response to extracellular stimulus GO:0031668 IEA     cellular response to interferon-alpha GO:0035457 IDA     positive regulation of protein kinase B signaling GO:0051897 IEA     phagocytosis GO:0006909 IDA     peptidyl-tyrosine phosphorylation GO:0018108 TAS     substrate adhesion-dependent cell spreading GO:0034446 IEA     cell maturation GO:0048469 IEP     blood vessel remodeling GO:0001974 IEA     erythrocyte homeostasis GO:0034101 IEA     negative regulation of dendritic cell apoptotic process GO:2000669 IDA     inflammatory response GO:0006954 IEA     secretion by cell GO:0032940 IEA     vagina development GO:0060068 IEA     protein kinase B signaling GO:0043491 IEA     platelet activation GO:0030168 IEA     negative regulation of interferon-gamma production GO:0032689 IDA     apoptotic cell clearance GO:0043277 IEA     positive regulation of cytokine-mediated signaling pathway GO:0001961 IDA     positive regulation of natural killer cell differentiation GO:0032825 IDA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     ovulation cycle GO:0042698 IEA     spermatogenesis GO:0007283 IEA     dendritic cell differentiation GO:0097028 IEP     cellular response to lipopolysaccharide GO:0071222 IDA     cellular response to hydrogen peroxide GO:0070301 IEA     positive regulation of pinocytosis GO:0048549 IMP     forebrain cell migration GO:0021885 IEA     signal transduction GO:0007165 TAS Subcellular Localization     plasma membrane GO:0005886 TAS     extracellular exosome GO:0070062 IDA     intracellular GO:0005622 IEA     integral component of plasma membrane GO:0005887 TAS     extracellular space GO:0005615 IDA     host cell surface GO:0044228 IDA     cell surface GO:0009986 IDA